Melatonin prevents endotoxin-induced circulatory failure in rats

Chin Chen Wu, Chin W. Chiao, George Hsiao, Ann Chen, Mao Hsiung Yen

Research output: Contribution to journalArticle

109 Citations (Scopus)

Abstract

The pineal secretory product melatonin was found to exert protective effects in septic shock. In a host infected by bacterial lipopolysaccharide (LPS), the expression and release of proinflammatory tumor necrosis factor-α (TNF-α) is rapidly increased, suggesting that TNF-α is associated with the etiology of endotoxic shock. Recent reports show that the expression of NO synthase (NOS) II and the production of superoxide anion (O2·-) also contribute to the pathophysiology of septic shock. In the present study we demonstrate that melatonin prevents circulatory failure in rats with endotoxemia and improves survival in mice treated with a lethal dose of LPS. The beneficial hemodynamic effects of melatonin in the endotoxemic animal appear to be associated with the inhibition of (i) the release of TNF-α in plasma, (ii) the expression of NOS II in liver, and (iii) the production of O2- in aortae. In addition, the infiltration of polymorphonuclear neutrophils into the liver from the surviving LPS mice treated with melatonin was reduced. Thus, our results support the clinical use of melatonin in endotoxemia.

Original languageEnglish
Pages (from-to)147-156
Number of pages10
JournalJournal of Pineal Research
Volume30
Issue number3
DOIs
Publication statusPublished - 2001

Fingerprint

Melatonin
Endotoxins
Shock
Septic Shock
Lipopolysaccharides
Endotoxemia
Tumor Necrosis Factor-alpha
Nitric Oxide Synthase
Neutrophil Infiltration
Liver
Superoxides
Aorta
Hemodynamics

Keywords

  • Lipopolysaccharide
  • Melatonin
  • NO synthase II
  • Polymorphonuclear neutrophils
  • Superoxide anion
  • Tumor necrosis factor-α

ASJC Scopus subject areas

  • Endocrinology

Cite this

Melatonin prevents endotoxin-induced circulatory failure in rats. / Wu, Chin Chen; Chiao, Chin W.; Hsiao, George; Chen, Ann; Yen, Mao Hsiung.

In: Journal of Pineal Research, Vol. 30, No. 3, 2001, p. 147-156.

Research output: Contribution to journalArticle

Wu, Chin Chen ; Chiao, Chin W. ; Hsiao, George ; Chen, Ann ; Yen, Mao Hsiung. / Melatonin prevents endotoxin-induced circulatory failure in rats. In: Journal of Pineal Research. 2001 ; Vol. 30, No. 3. pp. 147-156.
@article{e46698b89b474d9487997298fd0a406e,
title = "Melatonin prevents endotoxin-induced circulatory failure in rats",
abstract = "The pineal secretory product melatonin was found to exert protective effects in septic shock. In a host infected by bacterial lipopolysaccharide (LPS), the expression and release of proinflammatory tumor necrosis factor-α (TNF-α) is rapidly increased, suggesting that TNF-α is associated with the etiology of endotoxic shock. Recent reports show that the expression of NO synthase (NOS) II and the production of superoxide anion (O2·-) also contribute to the pathophysiology of septic shock. In the present study we demonstrate that melatonin prevents circulatory failure in rats with endotoxemia and improves survival in mice treated with a lethal dose of LPS. The beneficial hemodynamic effects of melatonin in the endotoxemic animal appear to be associated with the inhibition of (i) the release of TNF-α in plasma, (ii) the expression of NOS II in liver, and (iii) the production of O2- in aortae. In addition, the infiltration of polymorphonuclear neutrophils into the liver from the surviving LPS mice treated with melatonin was reduced. Thus, our results support the clinical use of melatonin in endotoxemia.",
keywords = "Lipopolysaccharide, Melatonin, NO synthase II, Polymorphonuclear neutrophils, Superoxide anion, Tumor necrosis factor-α",
author = "Wu, {Chin Chen} and Chiao, {Chin W.} and George Hsiao and Ann Chen and Yen, {Mao Hsiung}",
year = "2001",
doi = "10.1034/j.1600-079X.2001.300303.x",
language = "English",
volume = "30",
pages = "147--156",
journal = "Journal of Pineal Research",
issn = "0742-3098",
publisher = "Wiley-Blackwell",
number = "3",

}

TY - JOUR

T1 - Melatonin prevents endotoxin-induced circulatory failure in rats

AU - Wu, Chin Chen

AU - Chiao, Chin W.

AU - Hsiao, George

AU - Chen, Ann

AU - Yen, Mao Hsiung

PY - 2001

Y1 - 2001

N2 - The pineal secretory product melatonin was found to exert protective effects in septic shock. In a host infected by bacterial lipopolysaccharide (LPS), the expression and release of proinflammatory tumor necrosis factor-α (TNF-α) is rapidly increased, suggesting that TNF-α is associated with the etiology of endotoxic shock. Recent reports show that the expression of NO synthase (NOS) II and the production of superoxide anion (O2·-) also contribute to the pathophysiology of septic shock. In the present study we demonstrate that melatonin prevents circulatory failure in rats with endotoxemia and improves survival in mice treated with a lethal dose of LPS. The beneficial hemodynamic effects of melatonin in the endotoxemic animal appear to be associated with the inhibition of (i) the release of TNF-α in plasma, (ii) the expression of NOS II in liver, and (iii) the production of O2- in aortae. In addition, the infiltration of polymorphonuclear neutrophils into the liver from the surviving LPS mice treated with melatonin was reduced. Thus, our results support the clinical use of melatonin in endotoxemia.

AB - The pineal secretory product melatonin was found to exert protective effects in septic shock. In a host infected by bacterial lipopolysaccharide (LPS), the expression and release of proinflammatory tumor necrosis factor-α (TNF-α) is rapidly increased, suggesting that TNF-α is associated with the etiology of endotoxic shock. Recent reports show that the expression of NO synthase (NOS) II and the production of superoxide anion (O2·-) also contribute to the pathophysiology of septic shock. In the present study we demonstrate that melatonin prevents circulatory failure in rats with endotoxemia and improves survival in mice treated with a lethal dose of LPS. The beneficial hemodynamic effects of melatonin in the endotoxemic animal appear to be associated with the inhibition of (i) the release of TNF-α in plasma, (ii) the expression of NOS II in liver, and (iii) the production of O2- in aortae. In addition, the infiltration of polymorphonuclear neutrophils into the liver from the surviving LPS mice treated with melatonin was reduced. Thus, our results support the clinical use of melatonin in endotoxemia.

KW - Lipopolysaccharide

KW - Melatonin

KW - NO synthase II

KW - Polymorphonuclear neutrophils

KW - Superoxide anion

KW - Tumor necrosis factor-α

UR - http://www.scopus.com/inward/record.url?scp=0035087432&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0035087432&partnerID=8YFLogxK

U2 - 10.1034/j.1600-079X.2001.300303.x

DO - 10.1034/j.1600-079X.2001.300303.x

M3 - Article

C2 - 11316325

AN - SCOPUS:0035087432

VL - 30

SP - 147

EP - 156

JO - Journal of Pineal Research

JF - Journal of Pineal Research

SN - 0742-3098

IS - 3

ER -