Medium-chain triglycerides lower blood lipids and body weight in streptozotocin-induced type 2 diabetes rats

Ming Hua Sung, Fang Hsuean Liao, Yi Wen Chien

Research output: Contribution to journalArticle

2 Citations (Scopus)

Abstract

Medium-chain triglycerides (MCTs) are distinguished from other triglycerides in that each fat molecule consists of 6 to 12 carbons in length. MCTs and long-chain triglycerides (LCTs) are absorbed and utilized in different ways. The aim of this study was to assess the effects of replacing soybean oil with MCT oil, in a low-or high-fat diet, on lipid metabolism in rats with streptozotocin-induced type 2 diabetes mellitus (T2DM). There were, thirty-two T2DM Sprague-Dawley rats divided into low-fat-soybean oil (LS), low-fat-MCT oil (LM), high-fat-soybean oil (HS), and high-fat-MCT oil (HM) groups. After 8 weeks, blood sugar, serum lipids, liver lipids, and enzyme activities related to lipid metabolism were measured. Under a high-fat diet condition, replacement of soybean oil with MCT oil lowered serum low-density lipoprotein cholesterol (LDL-C), non-esterified fatty acids, and liver total cholesterol; whilst it increased serum high-density lipoprotein cholesterol (HDL-C) and the HDL-C/LDL-C ratio. A low-fat diet with MCT oil resulted in lower body weight and reproductive white adipose tissues compared to the HS groups, and higher hepatic acyl-CoA oxidase activities (the key enzyme in the peroxisomal beta-oxidation) compared to the LS group in T2DM rats. In conclusion, MCTs showed more protective effects on cardiovascular health in T2DM rats fed a high-fat diet, by improving serum lipid profiles and reducing hepatic total cholesterol.

Original languageEnglish
Article number963
JournalNutrients
Volume10
Issue number8
DOIs
Publication statusPublished - Aug 1 2018

Fingerprint

medium chain triacylglycerols
streptozotocin
Streptozocin
noninsulin-dependent diabetes mellitus
blood lipids
Type 2 Diabetes Mellitus
Triglycerides
Soybean Oil
Body Weight
soybean oil
body weight
rats
Fats
lipids
Oils
high fat diet
oils
High Fat Diet
low fat diet
low density lipoprotein cholesterol

Keywords

  • Lipid metabolism
  • Long-chain triglyceride
  • Medium-chain triglyceride
  • Type 2 diabetes mellitus

ASJC Scopus subject areas

  • Food Science
  • Nutrition and Dietetics

Cite this

Medium-chain triglycerides lower blood lipids and body weight in streptozotocin-induced type 2 diabetes rats. / Sung, Ming Hua; Liao, Fang Hsuean; Chien, Yi Wen.

In: Nutrients, Vol. 10, No. 8, 963, 01.08.2018.

Research output: Contribution to journalArticle

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