TY - JOUR
T1 - Medication-adherence predictors among patients with tuberculosis or human immunodeficiency virus infection in Burkina Faso
AU - Méda, Ziemlé Clément
AU - Lin, Yu Ting
AU - Sombié, Issiaka
AU - Maré, Daouda
AU - Morisky, Donald E.
AU - Chen, Yi Ming Arthur
N1 - Funding Information:
The authors wish to thank all individuals who participated in this study as well as the peer educators and social workers from the NGOs and the health workers from the public clinics for their help in collecting the questionnaires. We would also like to give special thanks to Mr Yahaya Nombré for supervising data collection, Mr Ibrahima R. Diallo for creating the EPIDATA file for the study, and Mr Cyprien Diarra and Mr Bakyono Francois for carrying out data entry. We are also grateful for the assistance of Dr Marcelo Chen from Mackay Memorial Hospital for editing the manuscript, and Drs Yen-Ju Chen, Ming-Wei Lin, and I-Fen Lin from the National Yang-Ming University for their advice in statistical analysis. This study was supported in part by grants from the AIDS Prevention and Research Center and the International Health Program of the Institute of Public Health , National Yang-Ming University of Taipei , Taiwan.
PY - 2014/1/1
Y1 - 2014/1/1
N2 - Background: Adherence to treatment remains a key issue for tuberculosis (TB) and human immunodeficiency virus (HIV) programs. The study objective was to identify potential determinants of medication adherence (MA) among patients with TB, HIV, or both. Methods: In this cross-sectional study, adult patients attending TB or HIV clinics were recruited in two main regions (Centre and Hauts-Bassins) of Burkina Faso from August to October 2010. Questionnaires were collected and simple and multiple step-wise linear regression models were used to identify predictors of MA. Results: In total, 1043 patients (309 with TB, 553 with HIV, and 181 coinfected with both) participated in this study. For patients with TB, adjusted predictors of good MA were no alcohol use, ever been lost to follow-up, and awareness of disease transmission. For patients with HIV, adjusted predictors of good MA were less stigma, good knowledge about TB transmission, and awareness of disease transmission. For patients with dual infection, adjusted predictors of good MA was good attitude. Furthermore, adjusted predictors of poor MA for patients with TB or with dual infection were poor financial access to care and high number of persons sleeping in the household, respectively. Conclusion: This study provides information on MA in patients infected with TB, HIV, and those coinfected with TB and HIV. TB and HIV programs have to consider the environment of the patient and its characteristics, including stigma, attitude, status of loss to follow-up, TB knowledge, financial access to care, alcohol use, awareness of disease transmission, and number of persons sleeping in the household. These identified factors in this study need to be taken into account for a specific patient profile and during sensitization, project planning, and research stages.
AB - Background: Adherence to treatment remains a key issue for tuberculosis (TB) and human immunodeficiency virus (HIV) programs. The study objective was to identify potential determinants of medication adherence (MA) among patients with TB, HIV, or both. Methods: In this cross-sectional study, adult patients attending TB or HIV clinics were recruited in two main regions (Centre and Hauts-Bassins) of Burkina Faso from August to October 2010. Questionnaires were collected and simple and multiple step-wise linear regression models were used to identify predictors of MA. Results: In total, 1043 patients (309 with TB, 553 with HIV, and 181 coinfected with both) participated in this study. For patients with TB, adjusted predictors of good MA were no alcohol use, ever been lost to follow-up, and awareness of disease transmission. For patients with HIV, adjusted predictors of good MA were less stigma, good knowledge about TB transmission, and awareness of disease transmission. For patients with dual infection, adjusted predictors of good MA was good attitude. Furthermore, adjusted predictors of poor MA for patients with TB or with dual infection were poor financial access to care and high number of persons sleeping in the household, respectively. Conclusion: This study provides information on MA in patients infected with TB, HIV, and those coinfected with TB and HIV. TB and HIV programs have to consider the environment of the patient and its characteristics, including stigma, attitude, status of loss to follow-up, TB knowledge, financial access to care, alcohol use, awareness of disease transmission, and number of persons sleeping in the household. These identified factors in this study need to be taken into account for a specific patient profile and during sensitization, project planning, and research stages.
KW - AIDS
KW - Burkina Faso
KW - Coinfection
KW - HIV
KW - Medication
KW - Predictor factors
KW - TB
KW - Treatment
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U2 - 10.1016/j.jmii.2013.05.001
DO - 10.1016/j.jmii.2013.05.001
M3 - Article
C2 - 23769812
AN - SCOPUS:84901638366
SN - 0253-2662
VL - 47
SP - 222
EP - 232
JO - Journal of Microbiology, Immunology and Infection
JF - Journal of Microbiology, Immunology and Infection
IS - 3
ER -
