Medial prefrontal cortex and nucleus accumbens core are involved in retrieval of the methamphetamine-associated memory

Chih Yuan Chiang, Chianfang G. Cherng, Yu Ting Lai, Hsin Yi Fan, Jia Ying Chuang, Gour Shenq Kao, Wan Ting Chang, Lung Yu

Research output: Contribution to journalArticle

11 Citations (Scopus)

Abstract

Immunohistochemical Fos staining has proven to be a method to identify the neurons that are activated by stimulation. Although methamphetamine (MA)-conditioned place preference (CPP) memory was long-lasting, how this memory was established and retrieved remained unknown. We used the vehicle- and MA-conditioned environment (including cues and context) to reactivate the MA-CPP memory in mice. In the limbic system, Fos-positive neurons were examined following retrieval of the MA-CPP memory. We demonstrated that the current conditioning procedure produced reliable MA-CPP performance. Moreover, enhanced Fos expressions were found in the medial prefrontal cortex and the core of the nucleus accumbens after reactivation of the MA-CPP memory. Furthermore, familiarity with the environmental cues/context was found to significantly enhance Fos expressions in dorsal striatum and dentate gyrus. Nucleus accumbens shell, basolateral or lateral amygdala, in this regard, did not seem to be involved in retrieval of the MA-CPP memory. These results, taken together, suggest that the medial prefrontal cortex and the core of the nucleus accumbens are anatomical substrates responsible for reactivation of the MA-CPP memory.

Original languageEnglish
Pages (from-to)24-30
Number of pages7
JournalBehavioural Brain Research
Volume197
Issue number1
DOIs
Publication statusPublished - Jan 30 2009
Externally publishedYes

Fingerprint

Methamphetamine
Nucleus Accumbens
Prefrontal Cortex
Cues
Neurons
Limbic System
Dentate Gyrus
Amygdala
Staining and Labeling

Keywords

  • Medial prefrontal cortex
  • Memory
  • Methamphetamine
  • Nucleus accumbens core
  • Pavlovian conditioning
  • Psychomotor stimulant

ASJC Scopus subject areas

  • Behavioral Neuroscience

Cite this

Medial prefrontal cortex and nucleus accumbens core are involved in retrieval of the methamphetamine-associated memory. / Chiang, Chih Yuan; Cherng, Chianfang G.; Lai, Yu Ting; Fan, Hsin Yi; Chuang, Jia Ying; Kao, Gour Shenq; Chang, Wan Ting; Yu, Lung.

In: Behavioural Brain Research, Vol. 197, No. 1, 30.01.2009, p. 24-30.

Research output: Contribution to journalArticle

Chiang, Chih Yuan ; Cherng, Chianfang G. ; Lai, Yu Ting ; Fan, Hsin Yi ; Chuang, Jia Ying ; Kao, Gour Shenq ; Chang, Wan Ting ; Yu, Lung. / Medial prefrontal cortex and nucleus accumbens core are involved in retrieval of the methamphetamine-associated memory. In: Behavioural Brain Research. 2009 ; Vol. 197, No. 1. pp. 24-30.
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