Mechanoelectrical feedback regulates the arrhythmogenic activity of pulmonary veins

S. L. Chang; Y. C. Chen; Y. J. Chen; W. Wangcharoen; S. H. Lee; C. I. Lin; S. A. Chen

doi:10.1136/hrt.2006.089359

Mechanoelectrical feedback regulates the arrhythmogenic activity of pulmonary veins

S. L. Chang, Y. C. Chen, Y. J. Chen, W. Wangcharoen, S. H. Lee, C. I. Lin, S. A. Chen

Research output: Contribution to journal › Article › peer-review

86 Citations (Scopus)

Abstract

Background: Atrial fibrillation is commonly associated with dilated pulmonary veins. Stretch has been shown to have mechano-electrical effects. Objective: To investigate whether stretch can increase the arrhythmogenic activity of the pulmonary veins. Methods: The transmembrane action potentials were recorded from rabbit pulmonary veins before and after stretch (100 and 300 mg). Gadolinium and streptomycin (stretch-activated ion channel blockers) were each perfused into the pulmonary veins under a 300-mg stretch. Results: Stretch (0, 100 and 300 mg) force dependently increased the incidence of spontaneous activity (22%, 48% and 83%; p

Original language	English
Pages (from-to)	82-88
Number of pages	7
Journal	Heart
Volume	93
Issue number	1
DOIs	https://doi.org/10.1136/hrt.2006.089359
Publication status	Published - Jan 2007

ASJC Scopus subject areas

Cardiology and Cardiovascular Medicine

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title = "Mechanoelectrical feedback regulates the arrhythmogenic activity of pulmonary veins",

abstract = "Background: Atrial fibrillation is commonly associated with dilated pulmonary veins. Stretch has been shown to have mechano-electrical effects. Objective: To investigate whether stretch can increase the arrhythmogenic activity of the pulmonary veins. Methods: The transmembrane action potentials were recorded from rabbit pulmonary veins before and after stretch (100 and 300 mg). Gadolinium and streptomycin (stretch-activated ion channel blockers) were each perfused into the pulmonary veins under a 300-mg stretch. Results: Stretch (0, 100 and 300 mg) force dependently increased the incidence of spontaneous activity (22%, 48% and 83%; p",

author = "Chang, {S. L.} and Chen, {Y. C.} and Chen, {Y. J.} and W. Wangcharoen and Lee, {S. H.} and Lin, {C. I.} and Chen, {S. A.}",

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T1 - Mechanoelectrical feedback regulates the arrhythmogenic activity of pulmonary veins

AU - Chang, S. L.

AU - Chen, Y. C.

AU - Chen, Y. J.

AU - Wangcharoen, W.

AU - Lee, S. H.

AU - Lin, C. I.

AU - Chen, S. A.

PY - 2007/1

Y1 - 2007/1

N2 - Background: Atrial fibrillation is commonly associated with dilated pulmonary veins. Stretch has been shown to have mechano-electrical effects. Objective: To investigate whether stretch can increase the arrhythmogenic activity of the pulmonary veins. Methods: The transmembrane action potentials were recorded from rabbit pulmonary veins before and after stretch (100 and 300 mg). Gadolinium and streptomycin (stretch-activated ion channel blockers) were each perfused into the pulmonary veins under a 300-mg stretch. Results: Stretch (0, 100 and 300 mg) force dependently increased the incidence of spontaneous activity (22%, 48% and 83%; p

AB - Background: Atrial fibrillation is commonly associated with dilated pulmonary veins. Stretch has been shown to have mechano-electrical effects. Objective: To investigate whether stretch can increase the arrhythmogenic activity of the pulmonary veins. Methods: The transmembrane action potentials were recorded from rabbit pulmonary veins before and after stretch (100 and 300 mg). Gadolinium and streptomycin (stretch-activated ion channel blockers) were each perfused into the pulmonary veins under a 300-mg stretch. Results: Stretch (0, 100 and 300 mg) force dependently increased the incidence of spontaneous activity (22%, 48% and 83%; p

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