Mechanoelectrical feedback regulates the arrhythmogenic activity of pulmonary veins

S. L. Chang; Y. C. Chen; Y. J. Chen; W. Wangcharoen; S. H. Lee; C. I. Lin; S. A. Chen

doi:10.1136/hrt.2006.089359

Mechanoelectrical feedback regulates the arrhythmogenic activity of pulmonary veins

S. L. Chang, Y. C. Chen, Y. J. Chen, W. Wangcharoen, S. H. Lee, C. I. Lin, S. A. Chen

Research output: Contribution to journal › Article

82 Citations (Scopus)

Abstract

Background: Atrial fibrillation is commonly associated with dilated pulmonary veins. Stretch has been shown to have mechano-electrical effects. Objective: To investigate whether stretch can increase the arrhythmogenic activity of the pulmonary veins. Methods: The transmembrane action potentials were recorded from rabbit pulmonary veins before and after stretch (100 and 300 mg). Gadolinium and streptomycin (stretch-activated ion channel blockers) were each perfused into the pulmonary veins under a 300-mg stretch. Results: Stretch (0, 100 and 300 mg) force dependently increased the incidence of spontaneous activity (22%, 48% and 83%; p

Original language	English
Pages (from-to)	82-88
Number of pages	7
Journal	Heart
Volume	93
Issue number	1
DOIs	https://doi.org/10.1136/hrt.2006.089359
Publication status	Published - Jan 2007

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Pulmonary Veins

Gadolinium

Streptomycin

Ion Channels

Membrane Potentials

Atrial Fibrillation

Action Potentials

Rabbits

Incidence

ASJC Scopus subject areas

Cardiology and Cardiovascular Medicine

Cite this

Chang, S. L., Chen, Y. C., Chen, Y. J., Wangcharoen, W., Lee, S. H., Lin, C. I., & Chen, S. A. (2007). Mechanoelectrical feedback regulates the arrhythmogenic activity of pulmonary veins. Heart, 93(1), 82-88. https://doi.org/10.1136/hrt.2006.089359

Mechanoelectrical feedback regulates the arrhythmogenic activity of pulmonary veins. / Chang, S. L.; Chen, Y. C.; Chen, Y. J.; Wangcharoen, W.; Lee, S. H.; Lin, C. I.; Chen, S. A.

In: Heart, Vol. 93, No. 1, 01.2007, p. 82-88.

Research output: Contribution to journal › Article

Chang, SL, Chen, YC, Chen, YJ, Wangcharoen, W, Lee, SH, Lin, CI & Chen, SA 2007, 'Mechanoelectrical feedback regulates the arrhythmogenic activity of pulmonary veins', Heart, vol. 93, no. 1, pp. 82-88. https://doi.org/10.1136/hrt.2006.089359

Chang SL, Chen YC, Chen YJ, Wangcharoen W, Lee SH, Lin CI et al. Mechanoelectrical feedback regulates the arrhythmogenic activity of pulmonary veins. Heart. 2007 Jan;93(1):82-88. https://doi.org/10.1136/hrt.2006.089359

Chang, S. L. ; Chen, Y. C. ; Chen, Y. J. ; Wangcharoen, W. ; Lee, S. H. ; Lin, C. I. ; Chen, S. A. / Mechanoelectrical feedback regulates the arrhythmogenic activity of pulmonary veins. In: Heart. 2007 ; Vol. 93, No. 1. pp. 82-88.

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10.1136/hrt.2006.089359