Mechanoelectrical feedback regulates the arrhythmogenic activity of pulmonary veins

S. L. Chang, Y. C. Chen, Y. J. Chen, W. Wangcharoen, S. H. Lee, C. I. Lin, S. A. Chen

Research output: Contribution to journalArticle

82 Citations (Scopus)

Abstract

Background: Atrial fibrillation is commonly associated with dilated pulmonary veins. Stretch has been shown to have mechano-electrical effects. Objective: To investigate whether stretch can increase the arrhythmogenic activity of the pulmonary veins. Methods: The transmembrane action potentials were recorded from rabbit pulmonary veins before and after stretch (100 and 300 mg). Gadolinium and streptomycin (stretch-activated ion channel blockers) were each perfused into the pulmonary veins under a 300-mg stretch. Results: Stretch (0, 100 and 300 mg) force dependently increased the incidence of spontaneous activity (22%, 48% and 83%; p

Original languageEnglish
Pages (from-to)82-88
Number of pages7
JournalHeart
Volume93
Issue number1
DOIs
Publication statusPublished - Jan 2007

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Pulmonary Veins
Gadolinium
Streptomycin
Ion Channels
Membrane Potentials
Atrial Fibrillation
Action Potentials
Rabbits
Incidence

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine

Cite this

Chang, S. L., Chen, Y. C., Chen, Y. J., Wangcharoen, W., Lee, S. H., Lin, C. I., & Chen, S. A. (2007). Mechanoelectrical feedback regulates the arrhythmogenic activity of pulmonary veins. Heart, 93(1), 82-88. https://doi.org/10.1136/hrt.2006.089359

Mechanoelectrical feedback regulates the arrhythmogenic activity of pulmonary veins. / Chang, S. L.; Chen, Y. C.; Chen, Y. J.; Wangcharoen, W.; Lee, S. H.; Lin, C. I.; Chen, S. A.

In: Heart, Vol. 93, No. 1, 01.2007, p. 82-88.

Research output: Contribution to journalArticle

Chang, SL, Chen, YC, Chen, YJ, Wangcharoen, W, Lee, SH, Lin, CI & Chen, SA 2007, 'Mechanoelectrical feedback regulates the arrhythmogenic activity of pulmonary veins', Heart, vol. 93, no. 1, pp. 82-88. https://doi.org/10.1136/hrt.2006.089359
Chang, S. L. ; Chen, Y. C. ; Chen, Y. J. ; Wangcharoen, W. ; Lee, S. H. ; Lin, C. I. ; Chen, S. A. / Mechanoelectrical feedback regulates the arrhythmogenic activity of pulmonary veins. In: Heart. 2007 ; Vol. 93, No. 1. pp. 82-88.
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