Abstract
Background: Atrial fibrillation is commonly associated with dilated pulmonary veins. Stretch has been shown to have mechano-electrical effects. Objective: To investigate whether stretch can increase the arrhythmogenic activity of the pulmonary veins. Methods: The transmembrane action potentials were recorded from rabbit pulmonary veins before and after stretch (100 and 300 mg). Gadolinium and streptomycin (stretch-activated ion channel blockers) were each perfused into the pulmonary veins under a 300-mg stretch. Results: Stretch (0, 100 and 300 mg) force dependently increased the incidence of spontaneous activity (22%, 48% and 83%; p
| Original language | English |
|---|---|
| Pages (from-to) | 82-88 |
| Number of pages | 7 |
| Journal | Heart |
| Volume | 93 |
| Issue number | 1 |
| DOIs | |
| Publication status | Published - Jan 2007 |
ASJC Scopus subject areas
- Cardiology and Cardiovascular Medicine
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Cite this
Chang, S. L., Chen, Y. C., Chen, Y. J., Wangcharoen, W., Lee, S. H., Lin, C. I., & Chen, S. A. (2007). Mechanoelectrical feedback regulates the arrhythmogenic activity of pulmonary veins. Heart, 93(1), 82-88. https://doi.org/10.1136/hrt.2006.089359