Abstract
Background: Atrial fibrillation is commonly associated with dilated pulmonary veins. Stretch has been shown to have mechano-electrical effects. Objective: To investigate whether stretch can increase the arrhythmogenic activity of the pulmonary veins. Methods: The transmembrane action potentials were recorded from rabbit pulmonary veins before and after stretch (100 and 300 mg). Gadolinium and streptomycin (stretch-activated ion channel blockers) were each perfused into the pulmonary veins under a 300-mg stretch. Results: Stretch (0, 100 and 300 mg) force dependently increased the incidence of spontaneous activity (22%, 48% and 83%; p
Original language | English |
---|---|
Pages (from-to) | 82-88 |
Number of pages | 7 |
Journal | Heart |
Volume | 93 |
Issue number | 1 |
DOIs | |
Publication status | Published - Jan 2007 |
ASJC Scopus subject areas
- Cardiology and Cardiovascular Medicine