Mechanistic impact of outdoor air pollution on asthma and allergic diseases

Shau Ku Huang, Qingling Zhang, Zhiming Qiu, Kian Fan Chung

Research output: Contribution to journalReview article

65 Citations (Scopus)

Abstract

Over the past decades, asthma and allergic diseases, such as allergic rhinitis and eczema, have become increasingly common, but the reason for this increased prevalence is still unclear. It has become apparent that genetic variation alone is not sufficient to account for the observed changes; rather, the changing environment, together with alterations in lifestyle and eating habits, are likely to have driven the increase in prevalence, and in some cases, severity of disease. This is particularly highlighted by recent awareness of, and concern about, the exposure to ubiquitous environmental pollutants, including chemicals with oxidant-generating capacities, and their impact on the human respiratory and immune systems. Indeed, several epidemiological studies have identified a variety of risk factors, including ambient pollutant gases and airborne particles, for the prevalence and the exacerbation of allergic diseases. However, the responsible pollutants remain unclear and the causal relationship has not been established. Recent studies of cellular and animal models have suggested several plausible mechanisms, with the most consistent observation being the direct effects of particle components on the generation of reactive oxygen species (ROS) and the resultant oxidative stress and inflammatory responses. This review attempts to highlight the experimental findings, with particular emphasis on several major mechanistic events initiated by exposure to particulate matters (PMs) in the exposure-disease relationship.

Original languageEnglish
Pages (from-to)23-33
Number of pages11
JournalJournal of Thoracic Disease
Volume7
Issue number1
DOIs
Publication statusPublished - Jan 1 2015
Externally publishedYes

Fingerprint

Air Pollution
Asthma
Environmental Pollutants
Particulate Matter
Eczema
Feeding Behavior
Oxidants
Respiratory System
Disease Progression
Life Style
Epidemiologic Studies
Immune System
Reactive Oxygen Species
Oxidative Stress
Animal Models
Gases
Observation

Keywords

  • Air pollution
  • Allergic disease
  • Aryl hydrocarbon receptor (AhR)
  • Asthma
  • Particulate matter (PM)
  • Polycyclic aromatic hydrocarbon (PAH)
  • Transition metal

ASJC Scopus subject areas

  • Pulmonary and Respiratory Medicine

Cite this

Mechanistic impact of outdoor air pollution on asthma and allergic diseases. / Huang, Shau Ku; Zhang, Qingling; Qiu, Zhiming; Chung, Kian Fan.

In: Journal of Thoracic Disease, Vol. 7, No. 1, 01.01.2015, p. 23-33.

Research output: Contribution to journalReview article

Huang, Shau Ku ; Zhang, Qingling ; Qiu, Zhiming ; Chung, Kian Fan. / Mechanistic impact of outdoor air pollution on asthma and allergic diseases. In: Journal of Thoracic Disease. 2015 ; Vol. 7, No. 1. pp. 23-33.
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