Mechanisms of ketamine-involved regulation of cytochrome P450 gene expression

Research output: Contribution to journalArticle

13 Citations (Scopus)

Abstract

Importance of the field: Ketamine, a widely used intravenous anesthetic agent, is biotransformed by cytochrome P450s (CYPs). Considerable attention is devoted to the ketamine-involved regulation of CYP gene expression. Assessing how ketamine regulates CYP gene expression is significant in recognizing the pharmacology of this anesthetic agent and its clinical application. Areas covered in this review: In this review, the authors discuss the effects of ketamine on the regulation of CYP gene expression and its possible mechanisms from the aspects of cytoskeletal remodeling, mitochondrial dysfunction, and alterations of intracellular ATP levels and calcium homeostasis. What the reader will gain: This review may provide readers with more clues for recognizing and avoiding possible ketamine-drug interactions. Take home message: Ketamine may inhibit CYP3A4 expression possibly through reducing calcium mobilization and mitochondrial ATP synthesis and consequently disturbing cytoskeleton remodeling.

Original languageEnglish
Pages (from-to)273-281
Number of pages9
JournalExpert Opinion on Drug Metabolism and Toxicology
Volume6
Issue number3
DOIs
Publication statusPublished - Mar 2010

Fingerprint

Ketamine
Gene expression
Cytochrome P-450 Enzyme System
Cytochromes
Gene Expression
Anesthetics
Adenosine Triphosphate
Drug interactions
Intravenous Anesthetics
Calcium
Cytochrome P-450 CYP3A
Cytoskeleton
Drug Interactions
Homeostasis
Pharmacology

Keywords

  • ATP
  • Calcium
  • CYPs
  • Cytoskeleton
  • Ketamine

ASJC Scopus subject areas

  • Toxicology
  • Pharmacology

Cite this

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abstract = "Importance of the field: Ketamine, a widely used intravenous anesthetic agent, is biotransformed by cytochrome P450s (CYPs). Considerable attention is devoted to the ketamine-involved regulation of CYP gene expression. Assessing how ketamine regulates CYP gene expression is significant in recognizing the pharmacology of this anesthetic agent and its clinical application. Areas covered in this review: In this review, the authors discuss the effects of ketamine on the regulation of CYP gene expression and its possible mechanisms from the aspects of cytoskeletal remodeling, mitochondrial dysfunction, and alterations of intracellular ATP levels and calcium homeostasis. What the reader will gain: This review may provide readers with more clues for recognizing and avoiding possible ketamine-drug interactions. Take home message: Ketamine may inhibit CYP3A4 expression possibly through reducing calcium mobilization and mitochondrial ATP synthesis and consequently disturbing cytoskeleton remodeling.",
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