Abstract

Pulmonary hypoplasia is common in the perinatal period and is a significant cause of death in newborn infants, and oligohydramnios is one of the most commonly associated abnormalities. Neonates exposed to oligohydramnios caused by premature rupture of membranes have an increased risk of acute respiratory morbidity. The exact mechanism by which oligohydramnios alters the respiratory system remains unknown. We herein report the effects of experimental oligohydramnios on lung growth and the expressions of growth factors and extracellular matrix in fetal rats on days 19 and 21 of gestation by producing oligohydramnios from days 16 to 21 of gestation in Sprague-Dawley dams. Rats exposed to oligohydramnios exhibited lung hypoplasia and significantly decreased expressions of extracellular matrix, transforming growth factor-β1 and platelet-derived growth factor on days 19 and 21 of gestation. Concomitant maternal retinoic acid treatment at a dose of 10 mg/kg increased platelet-derived growth factor expression but did not enhance fetal lung development. These results suggest that there is a stage-specific requirement for retinoic acid during lung development, and retinoic acid treatment should be applied with caution.

Original languageEnglish
Pages (from-to)104-110
Number of pages7
JournalJournal of Experimental and Clinical Medicine(Taiwan)
Volume2
Issue number3
DOIs
Publication statusPublished - Jun 2010

Fingerprint

Oligohydramnios
Lung
Tretinoin
Platelet-Derived Growth Factor
Pregnancy
Extracellular Matrix
Newborn Infant
Transforming Growth Factors
Fetal Development
Respiratory System
Rupture
Cause of Death
Intercellular Signaling Peptides and Proteins
Mothers
Morbidity
Membranes
Therapeutics
Growth

Keywords

  • Connective tissue
  • Growth factor
  • Lung hypoplasia
  • Platelet-derived
  • Retinoic acid
  • Transforming growth factor

ASJC Scopus subject areas

  • Medicine(all)

Cite this

Mechanism of Oligohydramnios-induced Pulmonary Hypoplasia. / Chen, Chung Ming; Wang, Leng-Fang; Chou, Hsiu Chu; Lang, Yaw Dong.

In: Journal of Experimental and Clinical Medicine(Taiwan), Vol. 2, No. 3, 06.2010, p. 104-110.

Research output: Contribution to journalArticle

@article{8412f411135349ad82b12529b952e2d6,
title = "Mechanism of Oligohydramnios-induced Pulmonary Hypoplasia",
abstract = "Pulmonary hypoplasia is common in the perinatal period and is a significant cause of death in newborn infants, and oligohydramnios is one of the most commonly associated abnormalities. Neonates exposed to oligohydramnios caused by premature rupture of membranes have an increased risk of acute respiratory morbidity. The exact mechanism by which oligohydramnios alters the respiratory system remains unknown. We herein report the effects of experimental oligohydramnios on lung growth and the expressions of growth factors and extracellular matrix in fetal rats on days 19 and 21 of gestation by producing oligohydramnios from days 16 to 21 of gestation in Sprague-Dawley dams. Rats exposed to oligohydramnios exhibited lung hypoplasia and significantly decreased expressions of extracellular matrix, transforming growth factor-β1 and platelet-derived growth factor on days 19 and 21 of gestation. Concomitant maternal retinoic acid treatment at a dose of 10 mg/kg increased platelet-derived growth factor expression but did not enhance fetal lung development. These results suggest that there is a stage-specific requirement for retinoic acid during lung development, and retinoic acid treatment should be applied with caution.",
keywords = "Connective tissue, Growth factor, Lung hypoplasia, Platelet-derived, Retinoic acid, Transforming growth factor",
author = "Chen, {Chung Ming} and Leng-Fang Wang and Chou, {Hsiu Chu} and Lang, {Yaw Dong}",
year = "2010",
month = "6",
doi = "10.1016/S1878-3317(10)60017-4",
language = "English",
volume = "2",
pages = "104--110",
journal = "Journal of Experimental and Clinical Medicine",
issn = "1878-3317",
publisher = "Elsevier Taiwan LLC",
number = "3",

}

TY - JOUR

T1 - Mechanism of Oligohydramnios-induced Pulmonary Hypoplasia

AU - Chen, Chung Ming

AU - Wang, Leng-Fang

AU - Chou, Hsiu Chu

AU - Lang, Yaw Dong

PY - 2010/6

Y1 - 2010/6

N2 - Pulmonary hypoplasia is common in the perinatal period and is a significant cause of death in newborn infants, and oligohydramnios is one of the most commonly associated abnormalities. Neonates exposed to oligohydramnios caused by premature rupture of membranes have an increased risk of acute respiratory morbidity. The exact mechanism by which oligohydramnios alters the respiratory system remains unknown. We herein report the effects of experimental oligohydramnios on lung growth and the expressions of growth factors and extracellular matrix in fetal rats on days 19 and 21 of gestation by producing oligohydramnios from days 16 to 21 of gestation in Sprague-Dawley dams. Rats exposed to oligohydramnios exhibited lung hypoplasia and significantly decreased expressions of extracellular matrix, transforming growth factor-β1 and platelet-derived growth factor on days 19 and 21 of gestation. Concomitant maternal retinoic acid treatment at a dose of 10 mg/kg increased platelet-derived growth factor expression but did not enhance fetal lung development. These results suggest that there is a stage-specific requirement for retinoic acid during lung development, and retinoic acid treatment should be applied with caution.

AB - Pulmonary hypoplasia is common in the perinatal period and is a significant cause of death in newborn infants, and oligohydramnios is one of the most commonly associated abnormalities. Neonates exposed to oligohydramnios caused by premature rupture of membranes have an increased risk of acute respiratory morbidity. The exact mechanism by which oligohydramnios alters the respiratory system remains unknown. We herein report the effects of experimental oligohydramnios on lung growth and the expressions of growth factors and extracellular matrix in fetal rats on days 19 and 21 of gestation by producing oligohydramnios from days 16 to 21 of gestation in Sprague-Dawley dams. Rats exposed to oligohydramnios exhibited lung hypoplasia and significantly decreased expressions of extracellular matrix, transforming growth factor-β1 and platelet-derived growth factor on days 19 and 21 of gestation. Concomitant maternal retinoic acid treatment at a dose of 10 mg/kg increased platelet-derived growth factor expression but did not enhance fetal lung development. These results suggest that there is a stage-specific requirement for retinoic acid during lung development, and retinoic acid treatment should be applied with caution.

KW - Connective tissue

KW - Growth factor

KW - Lung hypoplasia

KW - Platelet-derived

KW - Retinoic acid

KW - Transforming growth factor

UR - http://www.scopus.com/inward/record.url?scp=77953907688&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=77953907688&partnerID=8YFLogxK

U2 - 10.1016/S1878-3317(10)60017-4

DO - 10.1016/S1878-3317(10)60017-4

M3 - Article

AN - SCOPUS:77953907688

VL - 2

SP - 104

EP - 110

JO - Journal of Experimental and Clinical Medicine

JF - Journal of Experimental and Clinical Medicine

SN - 1878-3317

IS - 3

ER -