Measures of carotid-femoral pulse wave velocity and augmentation index are not reliable in patients with abdominal aortic aneurysm

Ching Wei Lee, Shih Hsien Sung, Chun Ku Chen, I. Ming Chen, Hao Min Cheng, Wen Chung Yu, Chun Che Shih, Chen Huan Chen

Research output: Contribution to journalArticle

17 Citations (Scopus)

Abstract

Background: Measures of carotid-femoral pulse wave velocity (cf-PWV) and carotid augmentation index (cAI) may be affected by the presence of an abdominal aortic aneurysm (AAA). We, therefore, investigated series of various measures of arterial stiffness and wave reflections in patients with AAA, before and 4 weeks after endovascular aneurysm repair (EVAR). Methods: A total of 51 patients (75.2 ± 11.6 years, 92.2% men) underwent EVAR for AAA and 51 controls with matched age, sex, SBP, and comorbidity were enrolled. Measures of aortic stiffness included cf-PWV by tonometry and brachial-ankle pulse wave velocity (ba-PWV) by plethysmography. Measures of wave reflections included cAI and the reflected pressure wave amplitude (Pb) from a decomposed carotid pressure wave. Results: Patients with AAA had significantly lower cf-PWV (12.1 ±2.7 versus 13.6±3.5m/s P = 0.009), higher cAI (30.8±12.2 versus 23.1 ±23.3%, P = 0.040) in comparison with controls. After EVAR for AAA, cf-PWV (14.4±3.8ms) increased significantly (P<0.001), and cAI (24.4±14.5%) decreased significantly (P=0.004). In contrast, ba-PWV and Pb values were similar to those in controls and did not change significantly after EVAR. Furthermore, the heart rate and mean BP adjusted post-EVAR cf-PWV, ba-PWV, cAI, and Pb were similar to the corresponding values in controls. Conclusion: In patients with AAA, a lower cf-PWV and a higher cAI are expected, which do not represent true degrees of arterial stiffness and wave reflections. EVAR may correct the impacts of AAA on cf-PWV and cAI.

Original languageEnglish
Pages (from-to)1853-1860
Number of pages8
JournalJournal of Hypertension
Volume31
Issue number9
DOIs
Publication statusPublished - Sep 1 2013
Externally publishedYes

Fingerprint

Pulse Wave Analysis
Abdominal Aortic Aneurysm
Thigh
Aneurysm
Vascular Stiffness
Ankle
Arm
Pressure
Plethysmography
Manometry
Comorbidity
Heart Rate

Keywords

  • Abdominal aortic aneurysm
  • Arterial stiffness
  • Carotid-femoral pulse wave velocity

ASJC Scopus subject areas

  • Internal Medicine
  • Physiology
  • Cardiology and Cardiovascular Medicine

Cite this

Measures of carotid-femoral pulse wave velocity and augmentation index are not reliable in patients with abdominal aortic aneurysm. / Lee, Ching Wei; Sung, Shih Hsien; Chen, Chun Ku; Chen, I. Ming; Cheng, Hao Min; Yu, Wen Chung; Shih, Chun Che; Chen, Chen Huan.

In: Journal of Hypertension, Vol. 31, No. 9, 01.09.2013, p. 1853-1860.

Research output: Contribution to journalArticle

Lee, Ching Wei ; Sung, Shih Hsien ; Chen, Chun Ku ; Chen, I. Ming ; Cheng, Hao Min ; Yu, Wen Chung ; Shih, Chun Che ; Chen, Chen Huan. / Measures of carotid-femoral pulse wave velocity and augmentation index are not reliable in patients with abdominal aortic aneurysm. In: Journal of Hypertension. 2013 ; Vol. 31, No. 9. pp. 1853-1860.
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abstract = "Background: Measures of carotid-femoral pulse wave velocity (cf-PWV) and carotid augmentation index (cAI) may be affected by the presence of an abdominal aortic aneurysm (AAA). We, therefore, investigated series of various measures of arterial stiffness and wave reflections in patients with AAA, before and 4 weeks after endovascular aneurysm repair (EVAR). Methods: A total of 51 patients (75.2 ± 11.6 years, 92.2{\%} men) underwent EVAR for AAA and 51 controls with matched age, sex, SBP, and comorbidity were enrolled. Measures of aortic stiffness included cf-PWV by tonometry and brachial-ankle pulse wave velocity (ba-PWV) by plethysmography. Measures of wave reflections included cAI and the reflected pressure wave amplitude (Pb) from a decomposed carotid pressure wave. Results: Patients with AAA had significantly lower cf-PWV (12.1 ±2.7 versus 13.6±3.5m/s P = 0.009), higher cAI (30.8±12.2 versus 23.1 ±23.3{\%}, P = 0.040) in comparison with controls. After EVAR for AAA, cf-PWV (14.4±3.8ms) increased significantly (P<0.001), and cAI (24.4±14.5{\%}) decreased significantly (P=0.004). In contrast, ba-PWV and Pb values were similar to those in controls and did not change significantly after EVAR. Furthermore, the heart rate and mean BP adjusted post-EVAR cf-PWV, ba-PWV, cAI, and Pb were similar to the corresponding values in controls. Conclusion: In patients with AAA, a lower cf-PWV and a higher cAI are expected, which do not represent true degrees of arterial stiffness and wave reflections. EVAR may correct the impacts of AAA on cf-PWV and cAI.",
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T1 - Measures of carotid-femoral pulse wave velocity and augmentation index are not reliable in patients with abdominal aortic aneurysm

AU - Lee, Ching Wei

AU - Sung, Shih Hsien

AU - Chen, Chun Ku

AU - Chen, I. Ming

AU - Cheng, Hao Min

AU - Yu, Wen Chung

AU - Shih, Chun Che

AU - Chen, Chen Huan

PY - 2013/9/1

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N2 - Background: Measures of carotid-femoral pulse wave velocity (cf-PWV) and carotid augmentation index (cAI) may be affected by the presence of an abdominal aortic aneurysm (AAA). We, therefore, investigated series of various measures of arterial stiffness and wave reflections in patients with AAA, before and 4 weeks after endovascular aneurysm repair (EVAR). Methods: A total of 51 patients (75.2 ± 11.6 years, 92.2% men) underwent EVAR for AAA and 51 controls with matched age, sex, SBP, and comorbidity were enrolled. Measures of aortic stiffness included cf-PWV by tonometry and brachial-ankle pulse wave velocity (ba-PWV) by plethysmography. Measures of wave reflections included cAI and the reflected pressure wave amplitude (Pb) from a decomposed carotid pressure wave. Results: Patients with AAA had significantly lower cf-PWV (12.1 ±2.7 versus 13.6±3.5m/s P = 0.009), higher cAI (30.8±12.2 versus 23.1 ±23.3%, P = 0.040) in comparison with controls. After EVAR for AAA, cf-PWV (14.4±3.8ms) increased significantly (P<0.001), and cAI (24.4±14.5%) decreased significantly (P=0.004). In contrast, ba-PWV and Pb values were similar to those in controls and did not change significantly after EVAR. Furthermore, the heart rate and mean BP adjusted post-EVAR cf-PWV, ba-PWV, cAI, and Pb were similar to the corresponding values in controls. Conclusion: In patients with AAA, a lower cf-PWV and a higher cAI are expected, which do not represent true degrees of arterial stiffness and wave reflections. EVAR may correct the impacts of AAA on cf-PWV and cAI.

AB - Background: Measures of carotid-femoral pulse wave velocity (cf-PWV) and carotid augmentation index (cAI) may be affected by the presence of an abdominal aortic aneurysm (AAA). We, therefore, investigated series of various measures of arterial stiffness and wave reflections in patients with AAA, before and 4 weeks after endovascular aneurysm repair (EVAR). Methods: A total of 51 patients (75.2 ± 11.6 years, 92.2% men) underwent EVAR for AAA and 51 controls with matched age, sex, SBP, and comorbidity were enrolled. Measures of aortic stiffness included cf-PWV by tonometry and brachial-ankle pulse wave velocity (ba-PWV) by plethysmography. Measures of wave reflections included cAI and the reflected pressure wave amplitude (Pb) from a decomposed carotid pressure wave. Results: Patients with AAA had significantly lower cf-PWV (12.1 ±2.7 versus 13.6±3.5m/s P = 0.009), higher cAI (30.8±12.2 versus 23.1 ±23.3%, P = 0.040) in comparison with controls. After EVAR for AAA, cf-PWV (14.4±3.8ms) increased significantly (P<0.001), and cAI (24.4±14.5%) decreased significantly (P=0.004). In contrast, ba-PWV and Pb values were similar to those in controls and did not change significantly after EVAR. Furthermore, the heart rate and mean BP adjusted post-EVAR cf-PWV, ba-PWV, cAI, and Pb were similar to the corresponding values in controls. Conclusion: In patients with AAA, a lower cf-PWV and a higher cAI are expected, which do not represent true degrees of arterial stiffness and wave reflections. EVAR may correct the impacts of AAA on cf-PWV and cAI.

KW - Abdominal aortic aneurysm

KW - Arterial stiffness

KW - Carotid-femoral pulse wave velocity

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