Matrix metalloproteinases (MMP) 1 and MMP10 but not MMP12 are potential oral cancer markers

Ching Yu Yen, Chung Ho Chen, Chao Hsiang Chang, Hung Fu Tseng, Shyun Yeu Liu, Li Yeh Chuang, Cheng Hao Wen, Hsueh Wei Chang

Research output: Contribution to journalArticle

49 Citations (Scopus)

Abstract

The aim of this study was to investigate the mRNA performance of matrix metalloproteinases (MMP) 1, MMP10 and MMP12 as oral cancer markers. With gingiva as the control, the areas under the receiver- operating characteristic curves (AUCs) of the relative gene expressions for MMP1, MMP10 and MMP12 were 0.715, 0.727 and 0.513, respectively. With the margins or neck platysma muscles as controls, the AUCs of MMP1, MMP10 and MMP12 were 0.746 vs 0.626, 0.712 vs 0.683 and 0.697 vs 0.630, respectively. MMP10 displayed the best sensitivity for oral cancer detection with any controls. MMP1 and MMP10 were suitable markers for cancer detection with gingiva and margin as controls. Using neck tissue as the control, only MMP10 was suitable for cancer detection. With margin and neck controls, there were no significant differences for MMP1, MMP10 and MMP12 in different stages, invasion and locations or different habits. Therefore, MMP1 and MMP10 but not MMP12 are potential oral cancer markers.

Original languageEnglish
Pages (from-to)244-249
Number of pages6
JournalBiomarkers
Volume14
Issue number4
DOIs
Publication statusPublished - Jun 2009

Fingerprint

Matrix Metalloproteinase 1
Mouth Neoplasms
Gingiva
Area Under Curve
Neck
Neck Muscles
ROC Curve
Habits
Neoplasms
Gene Expression
Messenger RNA
Gene expression
Muscle
Tissue

Keywords

  • Matrix metalloproteinases
  • Oral cancer
  • Receiver-operating characteristic curves
  • Tumour marker

ASJC Scopus subject areas

  • Biochemistry
  • Clinical Biochemistry
  • Health, Toxicology and Mutagenesis
  • Medicine(all)

Cite this

Yen, C. Y., Chen, C. H., Chang, C. H., Tseng, H. F., Liu, S. Y., Chuang, L. Y., ... Chang, H. W. (2009). Matrix metalloproteinases (MMP) 1 and MMP10 but not MMP12 are potential oral cancer markers. Biomarkers, 14(4), 244-249. https://doi.org/10.1080/13547500902829375

Matrix metalloproteinases (MMP) 1 and MMP10 but not MMP12 are potential oral cancer markers. / Yen, Ching Yu; Chen, Chung Ho; Chang, Chao Hsiang; Tseng, Hung Fu; Liu, Shyun Yeu; Chuang, Li Yeh; Wen, Cheng Hao; Chang, Hsueh Wei.

In: Biomarkers, Vol. 14, No. 4, 06.2009, p. 244-249.

Research output: Contribution to journalArticle

Yen, CY, Chen, CH, Chang, CH, Tseng, HF, Liu, SY, Chuang, LY, Wen, CH & Chang, HW 2009, 'Matrix metalloproteinases (MMP) 1 and MMP10 but not MMP12 are potential oral cancer markers', Biomarkers, vol. 14, no. 4, pp. 244-249. https://doi.org/10.1080/13547500902829375
Yen, Ching Yu ; Chen, Chung Ho ; Chang, Chao Hsiang ; Tseng, Hung Fu ; Liu, Shyun Yeu ; Chuang, Li Yeh ; Wen, Cheng Hao ; Chang, Hsueh Wei. / Matrix metalloproteinases (MMP) 1 and MMP10 but not MMP12 are potential oral cancer markers. In: Biomarkers. 2009 ; Vol. 14, No. 4. pp. 244-249.
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