Matrix metalloproteinase-9 production following cardiopulmonary bypass was not associated with pulmonary dysfunction after cardiac surgery

Tso Chou Lin, Feng Yen Lin, Yi Wen Lin, Che Hao Hsu, Go Shine Huang, Zhi Fu Wu, Yi Ting Tsai, Chih Yuan Lin, Chi Yuan Li, Chien Sung Tsai

Research output: Contribution to journalArticle

1 Citation (Scopus)

Abstract

Background. Cardiopulmonary bypass (CPB) causes release of matrix metalloproteinase- (MMP-) 9, contributing to pulmonary infiltration and dysfunction. The aims were to investigate MMP-9 production and associated perioperative variables and oxygenation following CPB. Methods. Thirty patients undergoing elective cardiac surgery were included. Arterial blood was sampled at 6 sequential points (before anesthesia induction, before CPB and at 2, 4, 6, and 24 h after beginning CPB) for plasma MMP-9 concentrations by ELISA. The perioperative laboratory data and variables, including bypass time, PaO2/FiO2, and extubation time, were also recorded. Results. The plasma MMP-9 concentrations significantly elevated at 2-6 h after beginning CPB (P <0.001) and returned to the preanesthesia level at 24 h (P = 0.23), with predominant neutrophil counts after surgery (P <0.001). The plasma MMP-9 levels at 4 and 6 h were not correlated with prolonged CPB time and displayed no association with postoperative PaO2/FiO2, regardless of reduced ratio from preoperative 342.9 ± 81.2 to postoperative 207.3 ± 121.3 mmHg (P <0.001). Conclusion. Elective cardiac surgery with CPB induced short-term elevation of plasma MMP-9 concentrations within 24 hours, however, without significant correlation with CPB time and postoperative pulmonary dysfunction, despite predominantly increased neutrophils and reduced oxygenation.

Original languageEnglish
Article number341740
JournalMediators of Inflammation
Volume2015
DOIs
Publication statusPublished - 2015

Fingerprint

Matrix Metalloproteinase 9
Cardiopulmonary Bypass
Thoracic Surgery
Lung
Neutrophils
Anesthesia
Enzyme-Linked Immunosorbent Assay

ASJC Scopus subject areas

  • Immunology
  • Cell Biology

Cite this

Matrix metalloproteinase-9 production following cardiopulmonary bypass was not associated with pulmonary dysfunction after cardiac surgery. / Lin, Tso Chou; Lin, Feng Yen; Lin, Yi Wen; Hsu, Che Hao; Huang, Go Shine; Wu, Zhi Fu; Tsai, Yi Ting; Lin, Chih Yuan; Li, Chi Yuan; Tsai, Chien Sung.

In: Mediators of Inflammation, Vol. 2015, 341740, 2015.

Research output: Contribution to journalArticle

Lin, Tso Chou ; Lin, Feng Yen ; Lin, Yi Wen ; Hsu, Che Hao ; Huang, Go Shine ; Wu, Zhi Fu ; Tsai, Yi Ting ; Lin, Chih Yuan ; Li, Chi Yuan ; Tsai, Chien Sung. / Matrix metalloproteinase-9 production following cardiopulmonary bypass was not associated with pulmonary dysfunction after cardiac surgery. In: Mediators of Inflammation. 2015 ; Vol. 2015.
@article{920944e95873424c9260c4ecab606468,
title = "Matrix metalloproteinase-9 production following cardiopulmonary bypass was not associated with pulmonary dysfunction after cardiac surgery",
abstract = "Background. Cardiopulmonary bypass (CPB) causes release of matrix metalloproteinase- (MMP-) 9, contributing to pulmonary infiltration and dysfunction. The aims were to investigate MMP-9 production and associated perioperative variables and oxygenation following CPB. Methods. Thirty patients undergoing elective cardiac surgery were included. Arterial blood was sampled at 6 sequential points (before anesthesia induction, before CPB and at 2, 4, 6, and 24 h after beginning CPB) for plasma MMP-9 concentrations by ELISA. The perioperative laboratory data and variables, including bypass time, PaO2/FiO2, and extubation time, were also recorded. Results. The plasma MMP-9 concentrations significantly elevated at 2-6 h after beginning CPB (P <0.001) and returned to the preanesthesia level at 24 h (P = 0.23), with predominant neutrophil counts after surgery (P <0.001). The plasma MMP-9 levels at 4 and 6 h were not correlated with prolonged CPB time and displayed no association with postoperative PaO2/FiO2, regardless of reduced ratio from preoperative 342.9 ± 81.2 to postoperative 207.3 ± 121.3 mmHg (P <0.001). Conclusion. Elective cardiac surgery with CPB induced short-term elevation of plasma MMP-9 concentrations within 24 hours, however, without significant correlation with CPB time and postoperative pulmonary dysfunction, despite predominantly increased neutrophils and reduced oxygenation.",
author = "Lin, {Tso Chou} and Lin, {Feng Yen} and Lin, {Yi Wen} and Hsu, {Che Hao} and Huang, {Go Shine} and Wu, {Zhi Fu} and Tsai, {Yi Ting} and Lin, {Chih Yuan} and Li, {Chi Yuan} and Tsai, {Chien Sung}",
year = "2015",
doi = "10.1155/2015/341740",
language = "English",
volume = "2015",
journal = "Mediators of Inflammation",
issn = "0962-9351",
publisher = "Hindawi Publishing Corporation",

}

TY - JOUR

T1 - Matrix metalloproteinase-9 production following cardiopulmonary bypass was not associated with pulmonary dysfunction after cardiac surgery

AU - Lin, Tso Chou

AU - Lin, Feng Yen

AU - Lin, Yi Wen

AU - Hsu, Che Hao

AU - Huang, Go Shine

AU - Wu, Zhi Fu

AU - Tsai, Yi Ting

AU - Lin, Chih Yuan

AU - Li, Chi Yuan

AU - Tsai, Chien Sung

PY - 2015

Y1 - 2015

N2 - Background. Cardiopulmonary bypass (CPB) causes release of matrix metalloproteinase- (MMP-) 9, contributing to pulmonary infiltration and dysfunction. The aims were to investigate MMP-9 production and associated perioperative variables and oxygenation following CPB. Methods. Thirty patients undergoing elective cardiac surgery were included. Arterial blood was sampled at 6 sequential points (before anesthesia induction, before CPB and at 2, 4, 6, and 24 h after beginning CPB) for plasma MMP-9 concentrations by ELISA. The perioperative laboratory data and variables, including bypass time, PaO2/FiO2, and extubation time, were also recorded. Results. The plasma MMP-9 concentrations significantly elevated at 2-6 h after beginning CPB (P <0.001) and returned to the preanesthesia level at 24 h (P = 0.23), with predominant neutrophil counts after surgery (P <0.001). The plasma MMP-9 levels at 4 and 6 h were not correlated with prolonged CPB time and displayed no association with postoperative PaO2/FiO2, regardless of reduced ratio from preoperative 342.9 ± 81.2 to postoperative 207.3 ± 121.3 mmHg (P <0.001). Conclusion. Elective cardiac surgery with CPB induced short-term elevation of plasma MMP-9 concentrations within 24 hours, however, without significant correlation with CPB time and postoperative pulmonary dysfunction, despite predominantly increased neutrophils and reduced oxygenation.

AB - Background. Cardiopulmonary bypass (CPB) causes release of matrix metalloproteinase- (MMP-) 9, contributing to pulmonary infiltration and dysfunction. The aims were to investigate MMP-9 production and associated perioperative variables and oxygenation following CPB. Methods. Thirty patients undergoing elective cardiac surgery were included. Arterial blood was sampled at 6 sequential points (before anesthesia induction, before CPB and at 2, 4, 6, and 24 h after beginning CPB) for plasma MMP-9 concentrations by ELISA. The perioperative laboratory data and variables, including bypass time, PaO2/FiO2, and extubation time, were also recorded. Results. The plasma MMP-9 concentrations significantly elevated at 2-6 h after beginning CPB (P <0.001) and returned to the preanesthesia level at 24 h (P = 0.23), with predominant neutrophil counts after surgery (P <0.001). The plasma MMP-9 levels at 4 and 6 h were not correlated with prolonged CPB time and displayed no association with postoperative PaO2/FiO2, regardless of reduced ratio from preoperative 342.9 ± 81.2 to postoperative 207.3 ± 121.3 mmHg (P <0.001). Conclusion. Elective cardiac surgery with CPB induced short-term elevation of plasma MMP-9 concentrations within 24 hours, however, without significant correlation with CPB time and postoperative pulmonary dysfunction, despite predominantly increased neutrophils and reduced oxygenation.

UR - http://www.scopus.com/inward/record.url?scp=84939182005&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84939182005&partnerID=8YFLogxK

U2 - 10.1155/2015/341740

DO - 10.1155/2015/341740

M3 - Article

C2 - 26273135

AN - SCOPUS:84939182005

VL - 2015

JO - Mediators of Inflammation

JF - Mediators of Inflammation

SN - 0962-9351

M1 - 341740

ER -