Matrix metalloproteinase-9 and spontaneous hemorrhage in an animal model of cerebral amyloid angiopathy

Jin Moo Lee, Ke Jie Yin, Idar Hsin, Shawei Chen, John D. Fryer, David M. Holtzman, Chung Y. Hsu, Jian Xu

Research output: Contribution to journalArticlepeer-review

84 Citations (Scopus)

Abstract

We examined the potential role of the extra-cellular matrix-degrading enzyme, matrix metalloproteinase-9 (MMP-9), in the pathogenesis of cerebral amyloid angiopathy (CAA)-induced spontaneous hemorrhage. The amyloid-beta peptide (Aβ) induced the synthesis, release and activation of MMP-9 in murine cerebral endothelial cells, resulting in increased extracellular matrix degradation. Furthermore, extensive MMP-9 immunoreactivity was observed in CAA-vessels with evidence of microhemorrhage in aged APPsw transgenic mice, but not detected in aged wild type or young APPsw mice. These results suggest that increased vascular MMP-9 expression, stimulated by Aβ, may play a role in the pathogenesis of spontaneous intracerebral hemorrhage in patients with CAA.

Original languageEnglish
Pages (from-to)379-382
Number of pages4
JournalAnnals of Neurology
Volume54
Issue number3
DOIs
Publication statusPublished - Sep 1 2003

ASJC Scopus subject areas

  • Neuroscience(all)

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