Matrix metalloproteinase-9 and spontaneous hemorrhage in an animal model of cerebral amyloid angiopathy

Jin Moo Lee, Ke Jie Yin, Idar Hsin, Shawei Chen, John D. Fryer, David M. Holtzman, Chung Y. Hsu, Jian Xu

Research output: Contribution to journalArticle

82 Citations (Scopus)

Abstract

We examined the potential role of the extra-cellular matrix-degrading enzyme, matrix metalloproteinase-9 (MMP-9), in the pathogenesis of cerebral amyloid angiopathy (CAA)-induced spontaneous hemorrhage. The amyloid-beta peptide (Aβ) induced the synthesis, release and activation of MMP-9 in murine cerebral endothelial cells, resulting in increased extracellular matrix degradation. Furthermore, extensive MMP-9 immunoreactivity was observed in CAA-vessels with evidence of microhemorrhage in aged APPsw transgenic mice, but not detected in aged wild type or young APPsw mice. These results suggest that increased vascular MMP-9 expression, stimulated by Aβ, may play a role in the pathogenesis of spontaneous intracerebral hemorrhage in patients with CAA.

Original languageEnglish
Pages (from-to)379-382
Number of pages4
JournalAnnals of Neurology
Volume54
Issue number3
DOIs
Publication statusPublished - Sep 1 2003

Fingerprint

Cerebral Amyloid Angiopathy
Matrix Metalloproteinase 9
Animal Models
Hemorrhage
Amyloid beta-Peptides
Cerebral Hemorrhage
Transgenic Mice
Extracellular Matrix
Blood Vessels
Endothelial Cells
Enzymes

ASJC Scopus subject areas

  • Neuroscience(all)

Cite this

Lee, J. M., Yin, K. J., Hsin, I., Chen, S., Fryer, J. D., Holtzman, D. M., ... Xu, J. (2003). Matrix metalloproteinase-9 and spontaneous hemorrhage in an animal model of cerebral amyloid angiopathy. Annals of Neurology, 54(3), 379-382. https://doi.org/10.1002/ana.10671

Matrix metalloproteinase-9 and spontaneous hemorrhage in an animal model of cerebral amyloid angiopathy. / Lee, Jin Moo; Yin, Ke Jie; Hsin, Idar; Chen, Shawei; Fryer, John D.; Holtzman, David M.; Hsu, Chung Y.; Xu, Jian.

In: Annals of Neurology, Vol. 54, No. 3, 01.09.2003, p. 379-382.

Research output: Contribution to journalArticle

Lee, JM, Yin, KJ, Hsin, I, Chen, S, Fryer, JD, Holtzman, DM, Hsu, CY & Xu, J 2003, 'Matrix metalloproteinase-9 and spontaneous hemorrhage in an animal model of cerebral amyloid angiopathy', Annals of Neurology, vol. 54, no. 3, pp. 379-382. https://doi.org/10.1002/ana.10671
Lee, Jin Moo ; Yin, Ke Jie ; Hsin, Idar ; Chen, Shawei ; Fryer, John D. ; Holtzman, David M. ; Hsu, Chung Y. ; Xu, Jian. / Matrix metalloproteinase-9 and spontaneous hemorrhage in an animal model of cerebral amyloid angiopathy. In: Annals of Neurology. 2003 ; Vol. 54, No. 3. pp. 379-382.
@article{43fb85cf8725481b9f0b0d6896aea3dd,
title = "Matrix metalloproteinase-9 and spontaneous hemorrhage in an animal model of cerebral amyloid angiopathy",
abstract = "We examined the potential role of the extra-cellular matrix-degrading enzyme, matrix metalloproteinase-9 (MMP-9), in the pathogenesis of cerebral amyloid angiopathy (CAA)-induced spontaneous hemorrhage. The amyloid-beta peptide (Aβ) induced the synthesis, release and activation of MMP-9 in murine cerebral endothelial cells, resulting in increased extracellular matrix degradation. Furthermore, extensive MMP-9 immunoreactivity was observed in CAA-vessels with evidence of microhemorrhage in aged APPsw transgenic mice, but not detected in aged wild type or young APPsw mice. These results suggest that increased vascular MMP-9 expression, stimulated by Aβ, may play a role in the pathogenesis of spontaneous intracerebral hemorrhage in patients with CAA.",
author = "Lee, {Jin Moo} and Yin, {Ke Jie} and Idar Hsin and Shawei Chen and Fryer, {John D.} and Holtzman, {David M.} and Hsu, {Chung Y.} and Jian Xu",
year = "2003",
month = "9",
day = "1",
doi = "10.1002/ana.10671",
language = "English",
volume = "54",
pages = "379--382",
journal = "Annals of Neurology",
issn = "0364-5134",
publisher = "John Wiley and Sons Inc.",
number = "3",

}

TY - JOUR

T1 - Matrix metalloproteinase-9 and spontaneous hemorrhage in an animal model of cerebral amyloid angiopathy

AU - Lee, Jin Moo

AU - Yin, Ke Jie

AU - Hsin, Idar

AU - Chen, Shawei

AU - Fryer, John D.

AU - Holtzman, David M.

AU - Hsu, Chung Y.

AU - Xu, Jian

PY - 2003/9/1

Y1 - 2003/9/1

N2 - We examined the potential role of the extra-cellular matrix-degrading enzyme, matrix metalloproteinase-9 (MMP-9), in the pathogenesis of cerebral amyloid angiopathy (CAA)-induced spontaneous hemorrhage. The amyloid-beta peptide (Aβ) induced the synthesis, release and activation of MMP-9 in murine cerebral endothelial cells, resulting in increased extracellular matrix degradation. Furthermore, extensive MMP-9 immunoreactivity was observed in CAA-vessels with evidence of microhemorrhage in aged APPsw transgenic mice, but not detected in aged wild type or young APPsw mice. These results suggest that increased vascular MMP-9 expression, stimulated by Aβ, may play a role in the pathogenesis of spontaneous intracerebral hemorrhage in patients with CAA.

AB - We examined the potential role of the extra-cellular matrix-degrading enzyme, matrix metalloproteinase-9 (MMP-9), in the pathogenesis of cerebral amyloid angiopathy (CAA)-induced spontaneous hemorrhage. The amyloid-beta peptide (Aβ) induced the synthesis, release and activation of MMP-9 in murine cerebral endothelial cells, resulting in increased extracellular matrix degradation. Furthermore, extensive MMP-9 immunoreactivity was observed in CAA-vessels with evidence of microhemorrhage in aged APPsw transgenic mice, but not detected in aged wild type or young APPsw mice. These results suggest that increased vascular MMP-9 expression, stimulated by Aβ, may play a role in the pathogenesis of spontaneous intracerebral hemorrhage in patients with CAA.

UR - http://www.scopus.com/inward/record.url?scp=0041835847&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0041835847&partnerID=8YFLogxK

U2 - 10.1002/ana.10671

DO - 10.1002/ana.10671

M3 - Article

VL - 54

SP - 379

EP - 382

JO - Annals of Neurology

JF - Annals of Neurology

SN - 0364-5134

IS - 3

ER -