Matrix Metalloproteinase-1 Polymorphism (-1607G) and Disease Severity in Non-Cystic Fibrosis Bronchiectasis in Taiwan

Meng Heng Hsieh, Pai Chien Chou, Chun Liang Chou, Shu Chuan Ho, Wen Ching Joa, Li Fei Chen, Te Fang Sheng, Horng Chyuan Lin, Tsai Yu Wang, Po Jui Chang, Chun Hua Wang, Han Pin Kuo

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14 Citations (Scopus)

Abstract

Objectives:Bronchiectasis is characterized by an irreversible dilatation of bronchi and is associated with lung fibrosis. MMP-1 polymorphism may alter its transcriptional activity, and differentially modulate bronchial destruction and lung fibrosis.Design:To investigate the association of MMP-1 polymorphisms with disease severity in non-cystic fibrosis (CF) bronchiectasis patients, 51 normal subjects and 113 patients with bronchiectasis were studied. The associations between MMP-1 polymorphisms, lung function, and disease severity evaluated by high resolution computed tomography (HRCT) were analyzed.Results:The frequency of MMP-1(-1607G) allele was significantly higher in patients with bronchiectasis than normal subjects (70.8% vs 45.1%, p

Original languageEnglish
Article numbere66265
JournalPLoS One
Volume8
Issue number6
DOIs
Publication statusPublished - Jun 11 2013
Externally publishedYes

ASJC Scopus subject areas

  • Agricultural and Biological Sciences(all)
  • Biochemistry, Genetics and Molecular Biology(all)
  • Medicine(all)

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    Hsieh, M. H., Chou, P. C., Chou, C. L., Ho, S. C., Joa, W. C., Chen, L. F., Sheng, T. F., Lin, H. C., Wang, T. Y., Chang, P. J., Wang, C. H., & Kuo, H. P. (2013). Matrix Metalloproteinase-1 Polymorphism (-1607G) and Disease Severity in Non-Cystic Fibrosis Bronchiectasis in Taiwan. PLoS One, 8(6), [e66265]. https://doi.org/10.1371/journal.pone.0066265