Matrix Metalloproteinase-1 Polymorphism (-1607G) and Disease Severity in Non-Cystic Fibrosis Bronchiectasis in Taiwan

Meng Heng Hsieh, Pai Chien Chou, Chun Liang Chou, Shu Chuan Ho, Wen Ching Joa, Li Fei Chen, Te Fang Sheng, Horng Chyuan Lin, Tsai Yu Wang, Po Jui Chang, Chun Hua Wang, Han Pin Kuo

Research output: Contribution to journalArticle

14 Citations (Scopus)

Abstract

Objectives:Bronchiectasis is characterized by an irreversible dilatation of bronchi and is associated with lung fibrosis. MMP-1 polymorphism may alter its transcriptional activity, and differentially modulate bronchial destruction and lung fibrosis.Design:To investigate the association of MMP-1 polymorphisms with disease severity in non-cystic fibrosis (CF) bronchiectasis patients, 51 normal subjects and 113 patients with bronchiectasis were studied. The associations between MMP-1 polymorphisms, lung function, and disease severity evaluated by high resolution computed tomography (HRCT) were analyzed.Results:The frequency of MMP-1(-1607G) allele was significantly higher in patients with bronchiectasis than normal subjects (70.8% vs 45.1%, p

Original languageEnglish
Article numbere66265
JournalPLoS One
Volume8
Issue number6
DOIs
Publication statusPublished - Jun 11 2013
Externally publishedYes

Fingerprint

interstitial collagenase
Matrix Metalloproteinase 1
Bronchiectasis
Polymorphism
Matrix Metalloproteinases
fibrosis
Taiwan
polymorphism
disease severity
Fibrosis
lungs
Lung
bronchi
lung function
Bronchi
computed tomography
respiratory tract diseases
Lung Diseases
Tomography
Dilatation

ASJC Scopus subject areas

  • Agricultural and Biological Sciences(all)
  • Biochemistry, Genetics and Molecular Biology(all)
  • Medicine(all)

Cite this

Matrix Metalloproteinase-1 Polymorphism (-1607G) and Disease Severity in Non-Cystic Fibrosis Bronchiectasis in Taiwan. / Hsieh, Meng Heng; Chou, Pai Chien; Chou, Chun Liang; Ho, Shu Chuan; Joa, Wen Ching; Chen, Li Fei; Sheng, Te Fang; Lin, Horng Chyuan; Wang, Tsai Yu; Chang, Po Jui; Wang, Chun Hua; Kuo, Han Pin.

In: PLoS One, Vol. 8, No. 6, e66265, 11.06.2013.

Research output: Contribution to journalArticle

Hsieh, Meng Heng ; Chou, Pai Chien ; Chou, Chun Liang ; Ho, Shu Chuan ; Joa, Wen Ching ; Chen, Li Fei ; Sheng, Te Fang ; Lin, Horng Chyuan ; Wang, Tsai Yu ; Chang, Po Jui ; Wang, Chun Hua ; Kuo, Han Pin. / Matrix Metalloproteinase-1 Polymorphism (-1607G) and Disease Severity in Non-Cystic Fibrosis Bronchiectasis in Taiwan. In: PLoS One. 2013 ; Vol. 8, No. 6.
@article{e17219a540c24d5ba815ff7d78124ff5,
title = "Matrix Metalloproteinase-1 Polymorphism (-1607G) and Disease Severity in Non-Cystic Fibrosis Bronchiectasis in Taiwan",
abstract = "Objectives:Bronchiectasis is characterized by an irreversible dilatation of bronchi and is associated with lung fibrosis. MMP-1 polymorphism may alter its transcriptional activity, and differentially modulate bronchial destruction and lung fibrosis.Design:To investigate the association of MMP-1 polymorphisms with disease severity in non-cystic fibrosis (CF) bronchiectasis patients, 51 normal subjects and 113 patients with bronchiectasis were studied. The associations between MMP-1 polymorphisms, lung function, and disease severity evaluated by high resolution computed tomography (HRCT) were analyzed.Results:The frequency of MMP-1(-1607G) allele was significantly higher in patients with bronchiectasis than normal subjects (70.8{\%} vs 45.1{\%}, p",
author = "Hsieh, {Meng Heng} and Chou, {Pai Chien} and Chou, {Chun Liang} and Ho, {Shu Chuan} and Joa, {Wen Ching} and Chen, {Li Fei} and Sheng, {Te Fang} and Lin, {Horng Chyuan} and Wang, {Tsai Yu} and Chang, {Po Jui} and Wang, {Chun Hua} and Kuo, {Han Pin}",
year = "2013",
month = "6",
day = "11",
doi = "10.1371/journal.pone.0066265",
language = "English",
volume = "8",
journal = "PLoS One",
issn = "1932-6203",
publisher = "Public Library of Science",
number = "6",

}

TY - JOUR

T1 - Matrix Metalloproteinase-1 Polymorphism (-1607G) and Disease Severity in Non-Cystic Fibrosis Bronchiectasis in Taiwan

AU - Hsieh, Meng Heng

AU - Chou, Pai Chien

AU - Chou, Chun Liang

AU - Ho, Shu Chuan

AU - Joa, Wen Ching

AU - Chen, Li Fei

AU - Sheng, Te Fang

AU - Lin, Horng Chyuan

AU - Wang, Tsai Yu

AU - Chang, Po Jui

AU - Wang, Chun Hua

AU - Kuo, Han Pin

PY - 2013/6/11

Y1 - 2013/6/11

N2 - Objectives:Bronchiectasis is characterized by an irreversible dilatation of bronchi and is associated with lung fibrosis. MMP-1 polymorphism may alter its transcriptional activity, and differentially modulate bronchial destruction and lung fibrosis.Design:To investigate the association of MMP-1 polymorphisms with disease severity in non-cystic fibrosis (CF) bronchiectasis patients, 51 normal subjects and 113 patients with bronchiectasis were studied. The associations between MMP-1 polymorphisms, lung function, and disease severity evaluated by high resolution computed tomography (HRCT) were analyzed.Results:The frequency of MMP-1(-1607G) allele was significantly higher in patients with bronchiectasis than normal subjects (70.8% vs 45.1%, p

AB - Objectives:Bronchiectasis is characterized by an irreversible dilatation of bronchi and is associated with lung fibrosis. MMP-1 polymorphism may alter its transcriptional activity, and differentially modulate bronchial destruction and lung fibrosis.Design:To investigate the association of MMP-1 polymorphisms with disease severity in non-cystic fibrosis (CF) bronchiectasis patients, 51 normal subjects and 113 patients with bronchiectasis were studied. The associations between MMP-1 polymorphisms, lung function, and disease severity evaluated by high resolution computed tomography (HRCT) were analyzed.Results:The frequency of MMP-1(-1607G) allele was significantly higher in patients with bronchiectasis than normal subjects (70.8% vs 45.1%, p

UR - http://www.scopus.com/inward/record.url?scp=84878828991&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84878828991&partnerID=8YFLogxK

U2 - 10.1371/journal.pone.0066265

DO - 10.1371/journal.pone.0066265

M3 - Article

C2 - 23776649

AN - SCOPUS:84878828991

VL - 8

JO - PLoS One

JF - PLoS One

SN - 1932-6203

IS - 6

M1 - e66265

ER -