Matrix metalloproteinase 1 gene polymorphism as a prognostic predictor of invasive cervical cancer

Hung Cheng Lai, Chi Ming Chu, Ya W. Lin, Cheng Chang Chang, Shin Nieh, Mu Hsien Yu, Tang Yuan Chu

Research output: Contribution to journalArticle

36 Citations (Scopus)

Abstract

Whereas human papillomavirus (HPV) infection is the major determinant of cervical carcinogenesis, host genetic factors may confer individual susceptibility and prognosis. Matrix metalloproteinase 1 (MMP-1) is an important modulator of carcinogenesis. A guanine insertion (2G) polymorphism at nucleotide -1607 of the MMP-1 gene promoter creates an Ets-1-binding site, which increases transcription activity. The present study investigates the association between MMP-1 polymorphism and cervical neoplasia, and their prognostic significance. In this study, the MMP-1 polymorphism was assessed in 135 high-grade squamous intraepithelial lesions (HSILs) and 197 invasive squamous cell carcinomas (SCCs), and in age-matched controls, by capillary electrophoresis. The association of clinicopathological factors and HPV status with MMP-1 genotypes was tested. Frequencies of the 2G allele in HSIL and SCC were 64% and 65%, respectively, which did not differ significantly from control values (66% and 64%, respectively). The 2G allele was associated with advanced stages of disease (P = 0.03), whereas the G allele was more common in patients with regional lymph node metastases (P = 0.02). The survival time in patients with the heterozygous genotype G/2G (median, 55.3 months) was significantly longer than those with either the G/G (50.3 months) or 2G/2G genotype (43.9 months) (P = 0.02). No significant correlation between HPV status and MMP-1 genotype was identified. The genetic polymorphisms of MMP-1 are not associated with the risk of HSIL and SCC, but with the invasiveness and prognosis of SCC. The heterozygous genotype of MMP-1 can be used as a prognostic marker in patients with invasive cervical cancer.

Original languageEnglish
Pages (from-to)314-319
Number of pages6
JournalGynecologic Oncology
Volume96
Issue number2
DOIs
Publication statusPublished - Feb 2005
Externally publishedYes

Fingerprint

Matrix Metalloproteinase 1
Uterine Cervical Neoplasms
Genotype
Genes
Squamous Cell Carcinoma
Carcinogenesis
Alleles
Papillomavirus Infections
Guanine
Capillary Electrophoresis
Genetic Polymorphisms
Gene Frequency
Nucleotides
Lymph Nodes
Binding Sites
Neoplasm Metastasis
Survival

Keywords

  • HPV
  • HSIL
  • MMP-1
  • Survival

ASJC Scopus subject areas

  • Obstetrics and Gynaecology
  • Oncology

Cite this

Matrix metalloproteinase 1 gene polymorphism as a prognostic predictor of invasive cervical cancer. / Lai, Hung Cheng; Chu, Chi Ming; Lin, Ya W.; Chang, Cheng Chang; Nieh, Shin; Yu, Mu Hsien; Chu, Tang Yuan.

In: Gynecologic Oncology, Vol. 96, No. 2, 02.2005, p. 314-319.

Research output: Contribution to journalArticle

Lai, Hung Cheng ; Chu, Chi Ming ; Lin, Ya W. ; Chang, Cheng Chang ; Nieh, Shin ; Yu, Mu Hsien ; Chu, Tang Yuan. / Matrix metalloproteinase 1 gene polymorphism as a prognostic predictor of invasive cervical cancer. In: Gynecologic Oncology. 2005 ; Vol. 96, No. 2. pp. 314-319.
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