Maternal nicotine exposure during gestation and lactation induces cardiac remodeling in rat offspring

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10 Citations (Scopus)

Abstract

The aim of this study was to evaluate the effects of maternal nicotine exposure on heart morphology and fibrosis in rat offspring. Nicotine was administered to pregnant Sprague-Dawley rats by using a subcutaneous osmotic mini-pump at a dose of 6. mg/kg/day from Gestational Days 7-21 or Gestational Day 7 to Postnatal Day 14. A control group received an equal volume of saline by the same route as nicotine. Rats born to prenatal nicotine-treated dams exhibited significantly greater cell width of cardiomyocytes, fewer cardiomyocyte nuclei number, higher β-myosin heavy chain and transforming growth factor (TGF-β1) expression, and higher collagen deposition in heart compared with rats born to normal saline-treated dams on Postnatal Days 7 and 21. Postnatal nicotine exposure further enhances these effects. We conclude that TGF-β1 may be involved in the pathogenesis of cardiac remodeling induced by maternal nicotine exposure during gestation and lactation in rat offspring.

Original languageEnglish
Pages (from-to)4-10
Number of pages7
JournalReproductive Toxicology
Volume50
DOIs
Publication statusPublished - Dec 1 2014

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Maternal Exposure
Nicotine
Lactation
Rats
Pregnancy
Cardiac Myocytes
Dams
Myosin Heavy Chains
Transforming Growth Factors
Sprague Dawley Rats
Fibrosis
Collagen
Pumps
Control Groups

Keywords

  • Collagen
  • Myosin heavy chain
  • Nicotine
  • Transforming growth factor-β1

ASJC Scopus subject areas

  • Toxicology
  • Medicine(all)

Cite this

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abstract = "The aim of this study was to evaluate the effects of maternal nicotine exposure on heart morphology and fibrosis in rat offspring. Nicotine was administered to pregnant Sprague-Dawley rats by using a subcutaneous osmotic mini-pump at a dose of 6. mg/kg/day from Gestational Days 7-21 or Gestational Day 7 to Postnatal Day 14. A control group received an equal volume of saline by the same route as nicotine. Rats born to prenatal nicotine-treated dams exhibited significantly greater cell width of cardiomyocytes, fewer cardiomyocyte nuclei number, higher β-myosin heavy chain and transforming growth factor (TGF-β1) expression, and higher collagen deposition in heart compared with rats born to normal saline-treated dams on Postnatal Days 7 and 21. Postnatal nicotine exposure further enhances these effects. We conclude that TGF-β1 may be involved in the pathogenesis of cardiac remodeling induced by maternal nicotine exposure during gestation and lactation in rat offspring.",
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