Masseter Muscle Volume Changes Evaluated by 3-Dimensional Computed Tomography After Repeated Botulinum Toxin A Injections in Patients With Square Facial Morphology

Chun Shin Chang, Susie Lin, Christopher Glenn Wallace, Yen Chang Hsiao, Che Min Lin, Gavin Chun Wui Kang, Zung Chung Chen, Philip Kuo Ting Chen, Lun Jou Lo, Yu Ray Chen, Jyh Ping Chen

Research output: Contribution to journalArticle

Abstract

INTRODUCTION: Botulinum neurotoxin A (BoNT-A) is a minimally invasive and technically straightforward treatment of masseter muscle (MM) volume reduction and facial contouring, but the literature on its long-term effect on MM volume remains unclear. OBJECTIVE: This study aimed to assess quantitatively for progressive volume changes of lower facial contour after 3 BoNT-A injections in patients with bilateral MM hypertrophy causing square facial morphology using 3-dimensional computed tomographic scans. MATERIALS AND METHODS: Ten female patients with square facial morphology due to bilateral MM hypertrophy were recruited to, and 6 completed, this clinical study. Each received 24 U of BoNT-A into the inferior portion of each MM on both sides, repeated 6 monthly to complete 3 treatments. Masseter muscle volume changes were assessed using 3-dimensional computed tomography at pretreatment (before injections) and posttreatment (1 year after the third injection). RESULTS: Mean MM volume significantly reduced from 26.39 ± 4.18 cm before treatment to 23.26 ± 4.31 cm 1 year after treatment (P = 0.002). CONCLUSION: Three consecutive 6-monthly BoNT-A injections into the MMs reduced their volume by 12% when assessed 1 year after completion of treatment.

Original languageEnglish
Pages (from-to)S29-S32
JournalAnnals of Plastic Surgery
Volume82
Issue number1S Suppl 1
DOIs
Publication statusPublished - Jan 1 2019
Externally publishedYes

Fingerprint

Masseter Muscle
Type A Botulinum Toxins
Tomography
Injections
Therapeutics

ASJC Scopus subject areas

  • Surgery

Cite this

Masseter Muscle Volume Changes Evaluated by 3-Dimensional Computed Tomography After Repeated Botulinum Toxin A Injections in Patients With Square Facial Morphology. / Chang, Chun Shin; Lin, Susie; Wallace, Christopher Glenn; Hsiao, Yen Chang; Lin, Che Min; Kang, Gavin Chun Wui; Chen, Zung Chung; Chen, Philip Kuo Ting; Lo, Lun Jou; Chen, Yu Ray; Chen, Jyh Ping.

In: Annals of Plastic Surgery, Vol. 82, No. 1S Suppl 1, 01.01.2019, p. S29-S32.

Research output: Contribution to journalArticle

Chang, Chun Shin ; Lin, Susie ; Wallace, Christopher Glenn ; Hsiao, Yen Chang ; Lin, Che Min ; Kang, Gavin Chun Wui ; Chen, Zung Chung ; Chen, Philip Kuo Ting ; Lo, Lun Jou ; Chen, Yu Ray ; Chen, Jyh Ping. / Masseter Muscle Volume Changes Evaluated by 3-Dimensional Computed Tomography After Repeated Botulinum Toxin A Injections in Patients With Square Facial Morphology. In: Annals of Plastic Surgery. 2019 ; Vol. 82, No. 1S Suppl 1. pp. S29-S32.
@article{cb2f75e3b18245778cdcb3f70658f6bc,
title = "Masseter Muscle Volume Changes Evaluated by 3-Dimensional Computed Tomography After Repeated Botulinum Toxin A Injections in Patients With Square Facial Morphology",
abstract = "INTRODUCTION: Botulinum neurotoxin A (BoNT-A) is a minimally invasive and technically straightforward treatment of masseter muscle (MM) volume reduction and facial contouring, but the literature on its long-term effect on MM volume remains unclear. OBJECTIVE: This study aimed to assess quantitatively for progressive volume changes of lower facial contour after 3 BoNT-A injections in patients with bilateral MM hypertrophy causing square facial morphology using 3-dimensional computed tomographic scans. MATERIALS AND METHODS: Ten female patients with square facial morphology due to bilateral MM hypertrophy were recruited to, and 6 completed, this clinical study. Each received 24 U of BoNT-A into the inferior portion of each MM on both sides, repeated 6 monthly to complete 3 treatments. Masseter muscle volume changes were assessed using 3-dimensional computed tomography at pretreatment (before injections) and posttreatment (1 year after the third injection). RESULTS: Mean MM volume significantly reduced from 26.39 ± 4.18 cm before treatment to 23.26 ± 4.31 cm 1 year after treatment (P = 0.002). CONCLUSION: Three consecutive 6-monthly BoNT-A injections into the MMs reduced their volume by 12{\%} when assessed 1 year after completion of treatment.",
author = "Chang, {Chun Shin} and Susie Lin and Wallace, {Christopher Glenn} and Hsiao, {Yen Chang} and Lin, {Che Min} and Kang, {Gavin Chun Wui} and Chen, {Zung Chung} and Chen, {Philip Kuo Ting} and Lo, {Lun Jou} and Chen, {Yu Ray} and Chen, {Jyh Ping}",
year = "2019",
month = "1",
day = "1",
doi = "10.1097/SAP.0000000000001705",
language = "English",
volume = "82",
pages = "S29--S32",
journal = "Annals of Plastic Surgery",
issn = "0148-7043",
publisher = "Lippincott Williams and Wilkins",
number = "1S Suppl 1",

}

TY - JOUR

T1 - Masseter Muscle Volume Changes Evaluated by 3-Dimensional Computed Tomography After Repeated Botulinum Toxin A Injections in Patients With Square Facial Morphology

AU - Chang, Chun Shin

AU - Lin, Susie

AU - Wallace, Christopher Glenn

AU - Hsiao, Yen Chang

AU - Lin, Che Min

AU - Kang, Gavin Chun Wui

AU - Chen, Zung Chung

AU - Chen, Philip Kuo Ting

AU - Lo, Lun Jou

AU - Chen, Yu Ray

AU - Chen, Jyh Ping

PY - 2019/1/1

Y1 - 2019/1/1

N2 - INTRODUCTION: Botulinum neurotoxin A (BoNT-A) is a minimally invasive and technically straightforward treatment of masseter muscle (MM) volume reduction and facial contouring, but the literature on its long-term effect on MM volume remains unclear. OBJECTIVE: This study aimed to assess quantitatively for progressive volume changes of lower facial contour after 3 BoNT-A injections in patients with bilateral MM hypertrophy causing square facial morphology using 3-dimensional computed tomographic scans. MATERIALS AND METHODS: Ten female patients with square facial morphology due to bilateral MM hypertrophy were recruited to, and 6 completed, this clinical study. Each received 24 U of BoNT-A into the inferior portion of each MM on both sides, repeated 6 monthly to complete 3 treatments. Masseter muscle volume changes were assessed using 3-dimensional computed tomography at pretreatment (before injections) and posttreatment (1 year after the third injection). RESULTS: Mean MM volume significantly reduced from 26.39 ± 4.18 cm before treatment to 23.26 ± 4.31 cm 1 year after treatment (P = 0.002). CONCLUSION: Three consecutive 6-monthly BoNT-A injections into the MMs reduced their volume by 12% when assessed 1 year after completion of treatment.

AB - INTRODUCTION: Botulinum neurotoxin A (BoNT-A) is a minimally invasive and technically straightforward treatment of masseter muscle (MM) volume reduction and facial contouring, but the literature on its long-term effect on MM volume remains unclear. OBJECTIVE: This study aimed to assess quantitatively for progressive volume changes of lower facial contour after 3 BoNT-A injections in patients with bilateral MM hypertrophy causing square facial morphology using 3-dimensional computed tomographic scans. MATERIALS AND METHODS: Ten female patients with square facial morphology due to bilateral MM hypertrophy were recruited to, and 6 completed, this clinical study. Each received 24 U of BoNT-A into the inferior portion of each MM on both sides, repeated 6 monthly to complete 3 treatments. Masseter muscle volume changes were assessed using 3-dimensional computed tomography at pretreatment (before injections) and posttreatment (1 year after the third injection). RESULTS: Mean MM volume significantly reduced from 26.39 ± 4.18 cm before treatment to 23.26 ± 4.31 cm 1 year after treatment (P = 0.002). CONCLUSION: Three consecutive 6-monthly BoNT-A injections into the MMs reduced their volume by 12% when assessed 1 year after completion of treatment.

UR - http://www.scopus.com/inward/record.url?scp=85058609718&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=85058609718&partnerID=8YFLogxK

U2 - 10.1097/SAP.0000000000001705

DO - 10.1097/SAP.0000000000001705

M3 - Article

VL - 82

SP - S29-S32

JO - Annals of Plastic Surgery

JF - Annals of Plastic Surgery

SN - 0148-7043

IS - 1S Suppl 1

ER -