Mass-like Dieulafoy's lesion associated with advanced gastric cancer at the antrum of stomach: A case report and literature review

Hsi Lan Huang, Chi Yan Leung, Chien Jui Cheng

Research output: Contribution to journalArticle

Abstract

Background: Dieulafoy's lesion, also known as a caliber-persistent artery, is a shallow, small, and rare lesion that occurs along the lesser curvature of proximal stomach. It is rare for a Dieulafoy's lesion to present as a mass-like lesion that coexists with gastric cancer. To our best knowledge, we report the first case and histopathological pictures of a mass-like Dieulafoy's lesion coexisting with advanced gastric cancer in the antrum of the stomach. Case presentation: A 57-year-old female presented with a 6-month history of intermittent epigastric dull pain and dyspepsia. Subsequent upper gastrointestinal endoscopy revealed a friable mass that was located between the distal antrum and the pyloric ring. Biopsy revealed it to be an intestinal type adenocarcinoma. Subtotal gastrectomy was performed after neoadjuvant chemotherapy. Grossly, a large irregular plaque-like tumor lesion was noted at the anterior wall of the distal antrum and pylorus ring near the lesser curvature, measuring 5.6 × 4.8 × 1.0 cm. Histopathological examination of the resected stomach revealed that the plaque-like lesion largely consisted of numerous abnormally large-caliber and tortuous arteries in the submucosa. The increased fibrosis of the submucosa resulted in the formation of elevated plaque. The intestinal type adenocarcinoma was noted to be largely confined to the mucosa layer, with focal submucosal and muscular propria involvement. The patient was discharged one week after the subtotal gastrectomy, and she was alive and well 17 months after discharge, with no major complications. Conclusion: This is the first case of a mass-like Dieulafoy's lesion coexisting with advanced gastric cancer at the distal antrum area. This case highlights the possibility of life-threatening gastric bleeding after mucosal resection or biopsy that could be encountered by endoscopists.

Original languageEnglish
Article number73
JournalDiagnostic Pathology
Volume12
Issue number1
DOIs
Publication statusPublished - Oct 10 2017

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Stomach Neoplasms
Stomach
Gastrectomy
Adenocarcinoma
Arteries
Biopsy
Pyloric Antrum
Gastrointestinal Endoscopy
Dyspepsia
Pylorus
Mucous Membrane
Fibrosis
Hemorrhage
Drug Therapy
Pain
Neoplasms

Keywords

  • Advanced gastric cancer
  • Antrum
  • Caliber-persistent artery
  • Dieulafoy's lesion
  • Gastrointestinal bleeding
  • Mass-like

ASJC Scopus subject areas

  • Pathology and Forensic Medicine
  • Histology

Cite this

Mass-like Dieulafoy's lesion associated with advanced gastric cancer at the antrum of stomach : A case report and literature review. / Huang, Hsi Lan; Leung, Chi Yan; Cheng, Chien Jui.

In: Diagnostic Pathology, Vol. 12, No. 1, 73, 10.10.2017.

Research output: Contribution to journalArticle

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