Markers for efficacy of mammalian target of rapamycin inhibitor

Yu Min Liao, Alex Sy, Yun Yen

Research output: Contribution to journalArticle

5 Citations (Scopus)

Abstract

Mammalian target of rapamycin (mTOR), an important sensor for growth factors, nutritional deprivation and other stresses in controling translation, plays a critical role in tumorigenesis. Several rapalogs exhibited antitumor activity clinically, with a modest average response rate, while a small subset of patients exhibited significantly greater clinical benefits. A better understanding of cellular mechanisms and the results of clinical studies can help identify an optimal biomarker to predict the efficacy of mTOR inhibitors. We discuss these potential markers in terms of selection of candidates, baseline expression, pathway inhibition and source of targeted protein.

Original languageEnglish
Pages (from-to)4235-4244
Number of pages10
JournalAnticancer Research
Volume32
Issue number10
Publication statusPublished - Oct 2012

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Keywords

  • Biomarker
  • mTOR inhibitor
  • Rapamycin
  • Review

ASJC Scopus subject areas

  • Cancer Research
  • Oncology

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