Marek's disease virus oncogenicity: Molecular mechanisms

Venugopal K. Nair, Hsing-Jien Kung

Research output: Chapter in Book/Report/Conference proceedingChapter

Abstract

This chapter discusses the oncogenicity of Marek's disease virus (MDV). It provides an overview of the roles of MDV genes that are potentially associated with latency/transformation. The onset of MDV-induced tumors is very rapid. The ability to induce rapid-onset tumors resembling those caused by some of the acutely transforming retroviruses suggests the direct involvement of virus-encoded transforming gene(s) in oncogenesis. Biochemical and genetic studies carried out in recent years suggest that Meq is the principal oncogene of MDV. Meq is a versatile protein that binds DNA, RNA, and a variety of other proteins. It also plays a potential role in the virulence replication and latency of MDV. Various investigations aimed at unravelling the oncogenic determinants of MDV have led to the identification of a number of other genes that have potential roles in the pathogenesis of MDV. Some of these MDV genes with a potential role in Marek's disease pathogenicity include the BamH1–H family of transcripts, the pp38/pp24 group of cytoplasmic phosphoproteins, the MDV-encoded CXC chemokine (vIL-8), the MDV-encoded telomerase RNA (vTR) subunit, and the MDV ICP4 homologue-related transcripts. The application of rapid, targeted, or random mutagenesis techniques enables rapid delineation of the molecular mechanisms and determinants for MDV-induced oncogenesis.
Original languageEnglish
Title of host publicationMarek's Disease
Subtitle of host publicationAn Evolving Problem
Pages32-48
ISBN (Electronic)9780080479187
Publication statusPublished - Jun 30 2004
Externally publishedYes

Fingerprint

Marek Disease
Viruses
Oncogenes
Virulence
Carcinogenesis
Genes
CXC Chemokines
Oncogenic Viruses
Phosphoproteins
Retroviridae
Mutagenesis

Cite this

Nair, V. K., & Kung, H-J. (2004). Marek's disease virus oncogenicity: Molecular mechanisms. In Marek's Disease : An Evolving Problem (pp. 32-48)

Marek's disease virus oncogenicity: Molecular mechanisms. / Nair, Venugopal K.; Kung, Hsing-Jien.

Marek's Disease : An Evolving Problem. 2004. p. 32-48.

Research output: Chapter in Book/Report/Conference proceedingChapter

Nair, VK & Kung, H-J 2004, Marek's disease virus oncogenicity: Molecular mechanisms. in Marek's Disease : An Evolving Problem. pp. 32-48.
Nair VK, Kung H-J. Marek's disease virus oncogenicity: Molecular mechanisms. In Marek's Disease : An Evolving Problem. 2004. p. 32-48
Nair, Venugopal K. ; Kung, Hsing-Jien. / Marek's disease virus oncogenicity: Molecular mechanisms. Marek's Disease : An Evolving Problem. 2004. pp. 32-48
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