Marek disease virus encodes a basic-leucine zipper gene resembling the fos/jun oncogenes that is highly expressed in lymphoblastoid tumors

Dan Jones, Lucy Lee, Juinn Lin Liu, Hsing Jien Rung, Joanne K. Tillotson

Research output: Contribution to journalArticle

180 Citations (Scopus)

Abstract

Marek disease virus (MDV) is a herpesvirus of chickens that induces T lymphomas within 3 weeks of infection. The short latency and polyclonal nature of MDV-induced tumors have suggested that the virus may encode one or more direct-acting oncogenes. To date, however, no MDV-specific tumor antigens or candidate transforming genes have been demonstrated. In this paper, we report the identification of a MDV gene encoding a protein with homology to the leucine-zipper class of nuclear oncogenes. It also contains a proline-rich domain characteristic of another class of transcription factors. This gene, designated meq, maps to the long repeat of MDV and is one of the few genes that are highly expressed in MDV-induced T-cell tumors. To our knowledge, a herpesvirus gene closely related to the fos/jun family of oncogenes has not been reported previously.

Original languageEnglish
Pages (from-to)4042-4046
Number of pages5
JournalProceedings of the National Academy of Sciences of the United States of America
Volume89
Issue number9
DOIs
Publication statusPublished - Jan 1 1992
Externally publishedYes

Fingerprint

jun Genes
Marek Disease
fos Genes
Leucine Zippers
Viruses
Oncogenes
Neoplasms
Herpesviridae
Genes
Oncogenic Viruses
Neoplasm Antigens
Proline
Chickens
Lymphoma
Transcription Factors
T-Lymphocytes
Infection

Keywords

  • Herpesvirus
  • T-cell lymphoma
  • Transactivator

ASJC Scopus subject areas

  • General

Cite this

Marek disease virus encodes a basic-leucine zipper gene resembling the fos/jun oncogenes that is highly expressed in lymphoblastoid tumors. / Jones, Dan; Lee, Lucy; Liu, Juinn Lin; Rung, Hsing Jien; Tillotson, Joanne K.

In: Proceedings of the National Academy of Sciences of the United States of America, Vol. 89, No. 9, 01.01.1992, p. 4042-4046.

Research output: Contribution to journalArticle

@article{52f088efe62243c895cffabbb302f4de,
title = "Marek disease virus encodes a basic-leucine zipper gene resembling the fos/jun oncogenes that is highly expressed in lymphoblastoid tumors",
abstract = "Marek disease virus (MDV) is a herpesvirus of chickens that induces T lymphomas within 3 weeks of infection. The short latency and polyclonal nature of MDV-induced tumors have suggested that the virus may encode one or more direct-acting oncogenes. To date, however, no MDV-specific tumor antigens or candidate transforming genes have been demonstrated. In this paper, we report the identification of a MDV gene encoding a protein with homology to the leucine-zipper class of nuclear oncogenes. It also contains a proline-rich domain characteristic of another class of transcription factors. This gene, designated meq, maps to the long repeat of MDV and is one of the few genes that are highly expressed in MDV-induced T-cell tumors. To our knowledge, a herpesvirus gene closely related to the fos/jun family of oncogenes has not been reported previously.",
keywords = "Herpesvirus, T-cell lymphoma, Transactivator",
author = "Dan Jones and Lucy Lee and Liu, {Juinn Lin} and Rung, {Hsing Jien} and Tillotson, {Joanne K.}",
year = "1992",
month = "1",
day = "1",
doi = "10.1073/pnas.89.9.4042",
language = "English",
volume = "89",
pages = "4042--4046",
journal = "Proceedings of the National Academy of Sciences of the United States of America",
issn = "0027-8424",
publisher = "National Academy of Sciences",
number = "9",

}

TY - JOUR

T1 - Marek disease virus encodes a basic-leucine zipper gene resembling the fos/jun oncogenes that is highly expressed in lymphoblastoid tumors

AU - Jones, Dan

AU - Lee, Lucy

AU - Liu, Juinn Lin

AU - Rung, Hsing Jien

AU - Tillotson, Joanne K.

PY - 1992/1/1

Y1 - 1992/1/1

N2 - Marek disease virus (MDV) is a herpesvirus of chickens that induces T lymphomas within 3 weeks of infection. The short latency and polyclonal nature of MDV-induced tumors have suggested that the virus may encode one or more direct-acting oncogenes. To date, however, no MDV-specific tumor antigens or candidate transforming genes have been demonstrated. In this paper, we report the identification of a MDV gene encoding a protein with homology to the leucine-zipper class of nuclear oncogenes. It also contains a proline-rich domain characteristic of another class of transcription factors. This gene, designated meq, maps to the long repeat of MDV and is one of the few genes that are highly expressed in MDV-induced T-cell tumors. To our knowledge, a herpesvirus gene closely related to the fos/jun family of oncogenes has not been reported previously.

AB - Marek disease virus (MDV) is a herpesvirus of chickens that induces T lymphomas within 3 weeks of infection. The short latency and polyclonal nature of MDV-induced tumors have suggested that the virus may encode one or more direct-acting oncogenes. To date, however, no MDV-specific tumor antigens or candidate transforming genes have been demonstrated. In this paper, we report the identification of a MDV gene encoding a protein with homology to the leucine-zipper class of nuclear oncogenes. It also contains a proline-rich domain characteristic of another class of transcription factors. This gene, designated meq, maps to the long repeat of MDV and is one of the few genes that are highly expressed in MDV-induced T-cell tumors. To our knowledge, a herpesvirus gene closely related to the fos/jun family of oncogenes has not been reported previously.

KW - Herpesvirus

KW - T-cell lymphoma

KW - Transactivator

UR - http://www.scopus.com/inward/record.url?scp=0026559338&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0026559338&partnerID=8YFLogxK

U2 - 10.1073/pnas.89.9.4042

DO - 10.1073/pnas.89.9.4042

M3 - Article

C2 - 1315048

AN - SCOPUS:0026559338

VL - 89

SP - 4042

EP - 4046

JO - Proceedings of the National Academy of Sciences of the United States of America

JF - Proceedings of the National Academy of Sciences of the United States of America

SN - 0027-8424

IS - 9

ER -