Mannose-binding lectin gene polymorphism contributes to recurrence of infective exacerbation in patients with COPD

Chii Lan Lin, Leung Kei Siu, Jung Chung Lin, Chien Ying Liu, Chih Feng Chian, Chun Nin Lee, Feng Yee Chang

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23 Citations (Scopus)

Abstract

Background: Mannose-binding lectin (MBL) deficiency is associated with susceptibility to respiratory infections. We investigated the impact of MBL2 gene polymorphisms and MBL deficiency on the recurrence of infective exacerbation in patients with COPD. Methods: A prospective study was conducted among 215 patients with COPD and 137 healthy subjects. MBL deficiency was determined by the MBL2 gene polymorphisms and serum levels of MBL. Results: The average frequency of infective exacerbations over 3 years in the 215 patients with COPD was 2.5 ± 1.3 episodes. The COPD group with three or more episodes of infective exacerbation (recurrent exacerbators) included 96 patients, and the remaining 119 patients had two or fewer episodes (less-frequent exacerbators). Among the 96 recurrent exacerbators, 12 (12.50%) had the MBL deficiency genotype compared with 5 (4.20%) among the less-frequent exacerbators (OR, 3.25; 95% CI, 1.01-11.07; P = .0253). In recurrent exacerbators, the frequency of infective exacerbation was significantly higher in patients with MBL-deficient genotypes than in those with non-MBL-deficient genotypes (4.75 ± 1.22 vs 3.52 ± 0.78, respectively; P

Original languageEnglish
Pages (from-to)43-51
Number of pages9
JournalChest
Volume139
Issue number1
DOIs
Publication statusPublished - Jan 1 2011
Externally publishedYes

ASJC Scopus subject areas

  • Pulmonary and Respiratory Medicine
  • Critical Care and Intensive Care Medicine
  • Cardiology and Cardiovascular Medicine

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    Lin, C. L., Siu, L. K., Lin, J. C., Liu, C. Y., Chian, C. F., Lee, C. N., & Chang, F. Y. (2011). Mannose-binding lectin gene polymorphism contributes to recurrence of infective exacerbation in patients with COPD. Chest, 139(1), 43-51. https://doi.org/10.1378/chest.10-0375