Manipulations of core temperatures in ischemia-reperfusion lung injury in rabbits

Hung Chang, Kun Lun Huang, Min Hui Li, Ching Wang Hsu, Shih Hung Tsai, Shi Jye Chu

Research output: Contribution to journalArticle

4 Citations (Scopus)

Abstract

The present study was designed to determine the effect of various core temperatures on acute lung injury induced by ischemia-reperfusion (I/R) in our isolated rabbit lung model. Typical acute lung injury was successfully induced by 30 min of ischemia followed by 90 min of reperfusion observation. The I/R elicited a significant increase in pulmonary arterial pressure, microvascular permeability (measured by using the capillary filtration coefficient, Kfc), ΔKfc ratio, lung weight gain and the protein concentration of the bronchoalveolar lavage fluid. Mild hypothermia significantly attenuated acute lung injury induced by I/R, all parameters having decreased significantly (p

Original languageEnglish
Pages (from-to)285-291
Number of pages7
JournalPulmonary Pharmacology and Therapeutics
Volume21
Issue number2
DOIs
Publication statusPublished - Apr 2008
Externally publishedYes

Keywords

  • Acute lung injury
  • Hyperthermia
  • Hypothermia
  • Ischemia-reperfusion injury

ASJC Scopus subject areas

  • Pulmonary and Respiratory Medicine
  • Pharmacology

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