Manipulations of core temperatures in ischemia-reperfusion lung injury in rabbits

Hung Chang, Kun Lun Huang, Min Hui Li, Ching Wang Hsu, Shih Hung Tsai, Shi Jye Chu

Research output: Contribution to journalArticle

4 Citations (Scopus)

Abstract

The present study was designed to determine the effect of various core temperatures on acute lung injury induced by ischemia-reperfusion (I/R) in our isolated rabbit lung model. Typical acute lung injury was successfully induced by 30 min of ischemia followed by 90 min of reperfusion observation. The I/R elicited a significant increase in pulmonary arterial pressure, microvascular permeability (measured by using the capillary filtration coefficient, Kfc), ΔKfc ratio, lung weight gain and the protein concentration of the bronchoalveolar lavage fluid. Mild hypothermia significantly attenuated acute lung injury induced by I/R, all parameters having decreased significantly (p

Original languageEnglish
Pages (from-to)285-291
Number of pages7
JournalPulmonary Pharmacology and Therapeutics
Volume21
Issue number2
DOIs
Publication statusPublished - Apr 2008
Externally publishedYes

Fingerprint

Hypothermia
Lung Injury
Reperfusion Injury
Reperfusion
Acute Lung Injury
Ischemia
Rabbits
Temperature
Fluids
Lung
Proteins
Bronchoalveolar Lavage Fluid
Capillary Permeability
Weight Gain
Arterial Pressure
Observation

Keywords

  • Acute lung injury
  • Hyperthermia
  • Hypothermia
  • Ischemia-reperfusion injury

ASJC Scopus subject areas

  • Pulmonary and Respiratory Medicine
  • Pharmacology

Cite this

Manipulations of core temperatures in ischemia-reperfusion lung injury in rabbits. / Chang, Hung; Huang, Kun Lun; Li, Min Hui; Hsu, Ching Wang; Tsai, Shih Hung; Chu, Shi Jye.

In: Pulmonary Pharmacology and Therapeutics, Vol. 21, No. 2, 04.2008, p. 285-291.

Research output: Contribution to journalArticle

Chang, Hung ; Huang, Kun Lun ; Li, Min Hui ; Hsu, Ching Wang ; Tsai, Shih Hung ; Chu, Shi Jye. / Manipulations of core temperatures in ischemia-reperfusion lung injury in rabbits. In: Pulmonary Pharmacology and Therapeutics. 2008 ; Vol. 21, No. 2. pp. 285-291.
@article{63e4c69a85b84a14b28faf02a33ad48a,
title = "Manipulations of core temperatures in ischemia-reperfusion lung injury in rabbits",
abstract = "The present study was designed to determine the effect of various core temperatures on acute lung injury induced by ischemia-reperfusion (I/R) in our isolated rabbit lung model. Typical acute lung injury was successfully induced by 30 min of ischemia followed by 90 min of reperfusion observation. The I/R elicited a significant increase in pulmonary arterial pressure, microvascular permeability (measured by using the capillary filtration coefficient, Kfc), ΔKfc ratio, lung weight gain and the protein concentration of the bronchoalveolar lavage fluid. Mild hypothermia significantly attenuated acute lung injury induced by I/R, all parameters having decreased significantly (p",
keywords = "Acute lung injury, Hyperthermia, Hypothermia, Ischemia-reperfusion injury",
author = "Hung Chang and Huang, {Kun Lun} and Li, {Min Hui} and Hsu, {Ching Wang} and Tsai, {Shih Hung} and Chu, {Shi Jye}",
year = "2008",
month = "4",
doi = "10.1016/j.pupt.2007.06.001",
language = "English",
volume = "21",
pages = "285--291",
journal = "Pulmonary Pharmacology and Therapeutics",
issn = "1094-5539",
publisher = "Academic Press Inc.",
number = "2",

}

TY - JOUR

T1 - Manipulations of core temperatures in ischemia-reperfusion lung injury in rabbits

AU - Chang, Hung

AU - Huang, Kun Lun

AU - Li, Min Hui

AU - Hsu, Ching Wang

AU - Tsai, Shih Hung

AU - Chu, Shi Jye

PY - 2008/4

Y1 - 2008/4

N2 - The present study was designed to determine the effect of various core temperatures on acute lung injury induced by ischemia-reperfusion (I/R) in our isolated rabbit lung model. Typical acute lung injury was successfully induced by 30 min of ischemia followed by 90 min of reperfusion observation. The I/R elicited a significant increase in pulmonary arterial pressure, microvascular permeability (measured by using the capillary filtration coefficient, Kfc), ΔKfc ratio, lung weight gain and the protein concentration of the bronchoalveolar lavage fluid. Mild hypothermia significantly attenuated acute lung injury induced by I/R, all parameters having decreased significantly (p

AB - The present study was designed to determine the effect of various core temperatures on acute lung injury induced by ischemia-reperfusion (I/R) in our isolated rabbit lung model. Typical acute lung injury was successfully induced by 30 min of ischemia followed by 90 min of reperfusion observation. The I/R elicited a significant increase in pulmonary arterial pressure, microvascular permeability (measured by using the capillary filtration coefficient, Kfc), ΔKfc ratio, lung weight gain and the protein concentration of the bronchoalveolar lavage fluid. Mild hypothermia significantly attenuated acute lung injury induced by I/R, all parameters having decreased significantly (p

KW - Acute lung injury

KW - Hyperthermia

KW - Hypothermia

KW - Ischemia-reperfusion injury

UR - http://www.scopus.com/inward/record.url?scp=39749111866&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=39749111866&partnerID=8YFLogxK

U2 - 10.1016/j.pupt.2007.06.001

DO - 10.1016/j.pupt.2007.06.001

M3 - Article

C2 - 17629529

AN - SCOPUS:39749111866

VL - 21

SP - 285

EP - 291

JO - Pulmonary Pharmacology and Therapeutics

JF - Pulmonary Pharmacology and Therapeutics

SN - 1094-5539

IS - 2

ER -