Mammographic tumour appearance and triple-negative breast cancer associated with long-term prognosis of breast cancer death

A Swedish Cohort Study

Huei Shian Tsau, Amy Ming Fang Yen, Jean Ching Yuan Fann, Wendy Yi Ying Wu, Cheng Ping Yu, Sam Li Sheng Chen, Sherry Yueh Hsia Chiu, László Tabár, Wen Hung Kuo, Hsiu Hsi Chen, King Jen Chang

Research output: Contribution to journalArticle

6 Citations (Scopus)

Abstract

Background: Numerous studies have paid attention to the role of the triple-negative marker in the prognosis of breast cancer, but very few studies have combined mammographic phenotypes with the triple-negative marker to assess their relevance to the long-term prognosis of breast cancer. The current study aims to assess the respective contributions of both mammographic tumour appearance and the triple-negative marker, and their possible interactions, on the long-term survival of breast cancer, taking into account the prognostic factors already established. Methods: A retrospective cohort of 498 breast cancer patients was enrolled at Falun Central Hospital, Sweden, between 1996 and 1998, and information on immunohistochemical markers and histological tumour distribution in these patients was collected. This cohort - together with prior information on conventional tumour attributes and mammographic tumour features from 1968 to 1995 - was formed by the Bayesian method and was followed over time until the end of 2011. Results: After considering tumour attributes, histological tumour distribution, and triple-negative cancer, two mammographic tumour features - casting type (adjusted hazard ratio, aHR. =. 3.47, 2.21-5.53) and architectural distortion (aHR. =. 4.43, 2.02-9.50) - had poorer survival compared to other types (stellate, circular, crushed-stone-like, and powdery mass). Triple-negative status conferred an independent 1.95-fold (1.06-3.52) higher risk for death from breast cancer than non-triple-negative status. Stratified by mammographic tumour features, the impact of triple-negative status on the prognosis of breast cancer was statistically significantly greater for the casting and architecturally distorted types (aHR. =. 5.40, 1.40-20.59) but was not statistically significant for other types of mammographic appearance (aHR. =. 1.75, 0.75-4.21). Stratified by the triple-negative feature, the effect of casting type and architectural distortion versus other tumour types on the risk of breast cancer death was statistically significant not only among triple-negative breast cancers (aHR. =. 9.67, 2.74-29.54) but also among non-triple-negative cancers (aHR. =. 4.11, 1.88-8.68). Conclusion: In addition to demonstrating mammographic appearance and the triple-negative feature as two independent prognostic factors, the most novel finding of this study is that the triple-negative feature played a more important role among breast tumours with the mammographic appearance of casting and architectural distortion than among tumours with other types of mammographic appearance. The risk stratification of long-term prognosis of breast cancer in the light of multi-attribute information in chronological order (mammographic tumour appearance first and then the triple-negative test) may aid clinicians in developing a customised schedule of surveillance and in optimising treatment and adjuvant therapy.

Original languageEnglish
Pages (from-to)200-208
Number of pages9
JournalCancer Epidemiology
Volume39
Issue number2
DOIs
Publication statusPublished - Apr 1 2015

Fingerprint

Triple Negative Breast Neoplasms
Cohort Studies
Breast Neoplasms
Neoplasms
Bayes Theorem
Survival
Tumor Biomarkers
Sweden

Keywords

  • Breast cancer
  • Mammography
  • Survival
  • Triple-negative

ASJC Scopus subject areas

  • Cancer Research
  • Oncology
  • Epidemiology

Cite this

Mammographic tumour appearance and triple-negative breast cancer associated with long-term prognosis of breast cancer death : A Swedish Cohort Study. / Tsau, Huei Shian; Yen, Amy Ming Fang; Fann, Jean Ching Yuan; Wu, Wendy Yi Ying; Yu, Cheng Ping; Chen, Sam Li Sheng; Chiu, Sherry Yueh Hsia; Tabár, László; Kuo, Wen Hung; Chen, Hsiu Hsi; Chang, King Jen.

In: Cancer Epidemiology, Vol. 39, No. 2, 01.04.2015, p. 200-208.

Research output: Contribution to journalArticle

Tsau, Huei Shian ; Yen, Amy Ming Fang ; Fann, Jean Ching Yuan ; Wu, Wendy Yi Ying ; Yu, Cheng Ping ; Chen, Sam Li Sheng ; Chiu, Sherry Yueh Hsia ; Tabár, László ; Kuo, Wen Hung ; Chen, Hsiu Hsi ; Chang, King Jen. / Mammographic tumour appearance and triple-negative breast cancer associated with long-term prognosis of breast cancer death : A Swedish Cohort Study. In: Cancer Epidemiology. 2015 ; Vol. 39, No. 2. pp. 200-208.
@article{5afe6d492bdd42f7855b0f5dfbfbacb2,
title = "Mammographic tumour appearance and triple-negative breast cancer associated with long-term prognosis of breast cancer death: A Swedish Cohort Study",
abstract = "Background: Numerous studies have paid attention to the role of the triple-negative marker in the prognosis of breast cancer, but very few studies have combined mammographic phenotypes with the triple-negative marker to assess their relevance to the long-term prognosis of breast cancer. The current study aims to assess the respective contributions of both mammographic tumour appearance and the triple-negative marker, and their possible interactions, on the long-term survival of breast cancer, taking into account the prognostic factors already established. Methods: A retrospective cohort of 498 breast cancer patients was enrolled at Falun Central Hospital, Sweden, between 1996 and 1998, and information on immunohistochemical markers and histological tumour distribution in these patients was collected. This cohort - together with prior information on conventional tumour attributes and mammographic tumour features from 1968 to 1995 - was formed by the Bayesian method and was followed over time until the end of 2011. Results: After considering tumour attributes, histological tumour distribution, and triple-negative cancer, two mammographic tumour features - casting type (adjusted hazard ratio, aHR. =. 3.47, 2.21-5.53) and architectural distortion (aHR. =. 4.43, 2.02-9.50) - had poorer survival compared to other types (stellate, circular, crushed-stone-like, and powdery mass). Triple-negative status conferred an independent 1.95-fold (1.06-3.52) higher risk for death from breast cancer than non-triple-negative status. Stratified by mammographic tumour features, the impact of triple-negative status on the prognosis of breast cancer was statistically significantly greater for the casting and architecturally distorted types (aHR. =. 5.40, 1.40-20.59) but was not statistically significant for other types of mammographic appearance (aHR. =. 1.75, 0.75-4.21). Stratified by the triple-negative feature, the effect of casting type and architectural distortion versus other tumour types on the risk of breast cancer death was statistically significant not only among triple-negative breast cancers (aHR. =. 9.67, 2.74-29.54) but also among non-triple-negative cancers (aHR. =. 4.11, 1.88-8.68). Conclusion: In addition to demonstrating mammographic appearance and the triple-negative feature as two independent prognostic factors, the most novel finding of this study is that the triple-negative feature played a more important role among breast tumours with the mammographic appearance of casting and architectural distortion than among tumours with other types of mammographic appearance. The risk stratification of long-term prognosis of breast cancer in the light of multi-attribute information in chronological order (mammographic tumour appearance first and then the triple-negative test) may aid clinicians in developing a customised schedule of surveillance and in optimising treatment and adjuvant therapy.",
keywords = "Breast cancer, Mammography, Survival, Triple-negative",
author = "Tsau, {Huei Shian} and Yen, {Amy Ming Fang} and Fann, {Jean Ching Yuan} and Wu, {Wendy Yi Ying} and Yu, {Cheng Ping} and Chen, {Sam Li Sheng} and Chiu, {Sherry Yueh Hsia} and L{\'a}szl{\'o} Tab{\'a}r and Kuo, {Wen Hung} and Chen, {Hsiu Hsi} and Chang, {King Jen}",
year = "2015",
month = "4",
day = "1",
doi = "10.1016/j.canep.2015.01.013",
language = "English",
volume = "39",
pages = "200--208",
journal = "Cancer Epidemiology",
issn = "1877-7821",
publisher = "Elsevier BV",
number = "2",

}

TY - JOUR

T1 - Mammographic tumour appearance and triple-negative breast cancer associated with long-term prognosis of breast cancer death

T2 - A Swedish Cohort Study

AU - Tsau, Huei Shian

AU - Yen, Amy Ming Fang

AU - Fann, Jean Ching Yuan

AU - Wu, Wendy Yi Ying

AU - Yu, Cheng Ping

AU - Chen, Sam Li Sheng

AU - Chiu, Sherry Yueh Hsia

AU - Tabár, László

AU - Kuo, Wen Hung

AU - Chen, Hsiu Hsi

AU - Chang, King Jen

PY - 2015/4/1

Y1 - 2015/4/1

N2 - Background: Numerous studies have paid attention to the role of the triple-negative marker in the prognosis of breast cancer, but very few studies have combined mammographic phenotypes with the triple-negative marker to assess their relevance to the long-term prognosis of breast cancer. The current study aims to assess the respective contributions of both mammographic tumour appearance and the triple-negative marker, and their possible interactions, on the long-term survival of breast cancer, taking into account the prognostic factors already established. Methods: A retrospective cohort of 498 breast cancer patients was enrolled at Falun Central Hospital, Sweden, between 1996 and 1998, and information on immunohistochemical markers and histological tumour distribution in these patients was collected. This cohort - together with prior information on conventional tumour attributes and mammographic tumour features from 1968 to 1995 - was formed by the Bayesian method and was followed over time until the end of 2011. Results: After considering tumour attributes, histological tumour distribution, and triple-negative cancer, two mammographic tumour features - casting type (adjusted hazard ratio, aHR. =. 3.47, 2.21-5.53) and architectural distortion (aHR. =. 4.43, 2.02-9.50) - had poorer survival compared to other types (stellate, circular, crushed-stone-like, and powdery mass). Triple-negative status conferred an independent 1.95-fold (1.06-3.52) higher risk for death from breast cancer than non-triple-negative status. Stratified by mammographic tumour features, the impact of triple-negative status on the prognosis of breast cancer was statistically significantly greater for the casting and architecturally distorted types (aHR. =. 5.40, 1.40-20.59) but was not statistically significant for other types of mammographic appearance (aHR. =. 1.75, 0.75-4.21). Stratified by the triple-negative feature, the effect of casting type and architectural distortion versus other tumour types on the risk of breast cancer death was statistically significant not only among triple-negative breast cancers (aHR. =. 9.67, 2.74-29.54) but also among non-triple-negative cancers (aHR. =. 4.11, 1.88-8.68). Conclusion: In addition to demonstrating mammographic appearance and the triple-negative feature as two independent prognostic factors, the most novel finding of this study is that the triple-negative feature played a more important role among breast tumours with the mammographic appearance of casting and architectural distortion than among tumours with other types of mammographic appearance. The risk stratification of long-term prognosis of breast cancer in the light of multi-attribute information in chronological order (mammographic tumour appearance first and then the triple-negative test) may aid clinicians in developing a customised schedule of surveillance and in optimising treatment and adjuvant therapy.

AB - Background: Numerous studies have paid attention to the role of the triple-negative marker in the prognosis of breast cancer, but very few studies have combined mammographic phenotypes with the triple-negative marker to assess their relevance to the long-term prognosis of breast cancer. The current study aims to assess the respective contributions of both mammographic tumour appearance and the triple-negative marker, and their possible interactions, on the long-term survival of breast cancer, taking into account the prognostic factors already established. Methods: A retrospective cohort of 498 breast cancer patients was enrolled at Falun Central Hospital, Sweden, between 1996 and 1998, and information on immunohistochemical markers and histological tumour distribution in these patients was collected. This cohort - together with prior information on conventional tumour attributes and mammographic tumour features from 1968 to 1995 - was formed by the Bayesian method and was followed over time until the end of 2011. Results: After considering tumour attributes, histological tumour distribution, and triple-negative cancer, two mammographic tumour features - casting type (adjusted hazard ratio, aHR. =. 3.47, 2.21-5.53) and architectural distortion (aHR. =. 4.43, 2.02-9.50) - had poorer survival compared to other types (stellate, circular, crushed-stone-like, and powdery mass). Triple-negative status conferred an independent 1.95-fold (1.06-3.52) higher risk for death from breast cancer than non-triple-negative status. Stratified by mammographic tumour features, the impact of triple-negative status on the prognosis of breast cancer was statistically significantly greater for the casting and architecturally distorted types (aHR. =. 5.40, 1.40-20.59) but was not statistically significant for other types of mammographic appearance (aHR. =. 1.75, 0.75-4.21). Stratified by the triple-negative feature, the effect of casting type and architectural distortion versus other tumour types on the risk of breast cancer death was statistically significant not only among triple-negative breast cancers (aHR. =. 9.67, 2.74-29.54) but also among non-triple-negative cancers (aHR. =. 4.11, 1.88-8.68). Conclusion: In addition to demonstrating mammographic appearance and the triple-negative feature as two independent prognostic factors, the most novel finding of this study is that the triple-negative feature played a more important role among breast tumours with the mammographic appearance of casting and architectural distortion than among tumours with other types of mammographic appearance. The risk stratification of long-term prognosis of breast cancer in the light of multi-attribute information in chronological order (mammographic tumour appearance first and then the triple-negative test) may aid clinicians in developing a customised schedule of surveillance and in optimising treatment and adjuvant therapy.

KW - Breast cancer

KW - Mammography

KW - Survival

KW - Triple-negative

UR - http://www.scopus.com/inward/record.url?scp=84926225749&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84926225749&partnerID=8YFLogxK

U2 - 10.1016/j.canep.2015.01.013

DO - 10.1016/j.canep.2015.01.013

M3 - Article

VL - 39

SP - 200

EP - 208

JO - Cancer Epidemiology

JF - Cancer Epidemiology

SN - 1877-7821

IS - 2

ER -