Malignancy After Heart Transplantation

Po Lin Chen, Hsiao Huang Chang, I. Ming Chen, Shiau Ting Lai, Chun Che Shih, Zen Chung Weng, Yuan Chen Hsieh, An Hang Yang

Research output: Contribution to journalArticle

12 Citations (Scopus)

Abstract

Background: The purpose of this study was to assess the incidence and type of malignancies after heart transplantation at a medical institute in Taiwan. Methods: From January 1987 to December 2008, a total of 66 patients who survived more than 30 days after transplantation were enrolled in this study. Results: Of the 66 heart transplant recipients, 8 (12.1%) post-transplant malignancies were diagnosed: 5 post- transplant lymphoproliferative diseases (PTLD), 1 prostate cancer, 1 lung cancer, and 1 squamous cell carcinoma of the cheek. The clinical presentations were diverse, and the diagnoses were confirmed by biopsy. Only 1 patient died of PTLD and subsequent multiple organ failure. Conclusion: Cancer is a limiting factor for long-term survival after heart transplantation. The most common type in this study was PTLD. Early detection and aggressive treatment results in good response and preserves the allograft.

Original languageEnglish
Pages (from-to)588-593
Number of pages6
JournalJournal of the Chinese Medical Association
Volume72
Issue number11
DOIs
Publication statusPublished - Nov 1 2009
Externally publishedYes

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Keywords

  • heart transplantation
  • malignancy
  • post-transplant lymphoproliferative disorder

ASJC Scopus subject areas

  • Medicine(all)

Cite this

Chen, P. L., Chang, H. H., Chen, I. M., Lai, S. T., Shih, C. C., Weng, Z. C., Hsieh, Y. C., & Yang, A. H. (2009). Malignancy After Heart Transplantation. Journal of the Chinese Medical Association, 72(11), 588-593. https://doi.org/10.1016/S1726-4901(09)70434-4