Major brain lesions detected on sonographic screening of apparently normal term neonates

L. W. Wang, C. C. Huang, T. F. Yeh

Research output: Contribution to journalArticle

50 Citations (Scopus)

Abstract

Major congenital or acquired structural abnormalities of the brain, with significant prognostic implications have rarely been emphasised in apparently normal infants. Our purpose was to investigate the prevalence and types of major brain lesions in clinically normal term neonates using sonography. From January 1999 to December 2001, we examined 2309 clinically normal term neonates within 3 days of birth. Of these, six (0.26%) had major brain lesions, including three cases of intracerebral haemorrhage (two grade II intraventricular and one temporal lobe haemorrhage), two of corpus callosum agenesis and one lacunar infarct in the territory of the left middle cerebral artery. One child was lost to follow-up, because of adoption, and four had borderline to significant developmental delay at a mean age of 24 months (range 12-36 months). Although the prevalence of major brain lesions was low, these infants have a higher risk of later neurodevelopmental disability, despite an early asymptomatic period. Universal neonatal brain ultrasound screening may help early diagnosis of rare major lesions, some of which have prognostic implications.

Original languageEnglish
Pages (from-to)368-373
Number of pages6
JournalNeuroradiology
Volume46
Issue number5
DOIs
Publication statusPublished - May 2004
Externally publishedYes

Fingerprint

Newborn Infant
Brain
Agenesis of Corpus Callosum
Lacunar Stroke
Lost to Follow-Up
Cerebral Hemorrhage
Middle Cerebral Artery
Temporal Lobe
Early Diagnosis
Ultrasonography
Parturition
Hemorrhage

Keywords

  • Cranial sonography
  • Term neonates

ASJC Scopus subject areas

  • Radiology Nuclear Medicine and imaging
  • Clinical Neurology
  • Radiological and Ultrasound Technology

Cite this

Major brain lesions detected on sonographic screening of apparently normal term neonates. / Wang, L. W.; Huang, C. C.; Yeh, T. F.

In: Neuroradiology, Vol. 46, No. 5, 05.2004, p. 368-373.

Research output: Contribution to journalArticle

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