Magnetoencephalographic yield of interictal spikes in temporal lobe epilepsy: Comparison with scalp EEG recordings

Y. Y. Lin, Y. H. Shih, J. C. Hsieh, H. Y. Yu, C. H. Yiu, Tai-Tong Wong, T. C. Yeh, S. Y. Kwan, L. T. Ho, D. J. Yen, Z. A. Wu, M. S. Chang

Research output: Contribution to journalArticle

61 Citations (Scopus)

Abstract

To compare magnetoencephalography (MEG) with scalp electroencephalography (EEG) in the detection of interictal spikes in temporal lobe epilepsy (TLE), we simultaneously recorded MEG and scalp EEG with a whole-scalp neuromagnetometer in 46 TLE patients. We visually searched interictal spikes on MEG and EEG channels and classified them into three types according to their presentation on MEG alone (M-spikes), EEG alone (E-spikes), or concomitantly on both modalities (M/E-spikes). The M-spikes and M/E-spikes were localized with MEG equivalent current dipole modeling. We analyzed the relative contribution of MEG and EEG in the overall yield of spike detection and also compared M-spikes with M/E-spikes in terms of dipole locations and strengths. During the 30- to 40-min MEG recordings, interictal spikes were obtained in 36 (78.3%) of the 46 patients. Among the 36 patients, most spikes were M/E-spikes (68.3%), some were M-spikes (22.1%), and some were E-spikes (9.7%). In comparison with EEG, MEG gave better spike yield in patients with lateral TLE. Sources of M/E- and M-spikes were situated in the same anatomical regions, whereas the average dipole strength was larger for M/E- than M-spikes. In conclusion, some interictal spikes appeared selectively on either MEG or EEG channels in TLE patients although more spikes were simultaneously identified on both modalities. Thus, simultaneous MEG and EEG recordings help to enhance spike detection. Identification of M-spikes would offer important localization of irritative foci, especially in patients with lateral TLE.

Original languageEnglish
Pages (from-to)1115-1126
Number of pages12
JournalNeuroImage
Volume19
Issue number3
DOIs
Publication statusPublished - Jul 1 2003
Externally publishedYes

Keywords

  • Interictal spikes
  • Magnetoencephalography
  • Scalp EEG
  • Spike detection
  • Temporal lobe epilepsy

ASJC Scopus subject areas

  • Neurology
  • Cognitive Neuroscience

Fingerprint Dive into the research topics of 'Magnetoencephalographic yield of interictal spikes in temporal lobe epilepsy: Comparison with scalp EEG recordings'. Together they form a unique fingerprint.

  • Cite this

    Lin, Y. Y., Shih, Y. H., Hsieh, J. C., Yu, H. Y., Yiu, C. H., Wong, T-T., Yeh, T. C., Kwan, S. Y., Ho, L. T., Yen, D. J., Wu, Z. A., & Chang, M. S. (2003). Magnetoencephalographic yield of interictal spikes in temporal lobe epilepsy: Comparison with scalp EEG recordings. NeuroImage, 19(3), 1115-1126. https://doi.org/10.1016/S1053-8119(03)00181-2