Magnetoencephalographic characteristics of interictal spikes in TLE

Yung Yang Lin, Chun Hing Yiu, Hsiang Yu Yu, Jen Chuen Hsieh, Shang Yeong Kwan, Der Jen Yen, Kai Ping Chang, Yang Hsih Shih, Tai-Tong Wong

Research output: Contribution to journalArticle

2 Citations (Scopus)

Abstract

Purpose: To characterize the localization of interictal spikes by magnetoencephalography (MEG) in patients with mesial temporal lobe epilepsy (TLE). Methods: We studied 5 patients with mesial TLE who had convergent localization information based on presurgical evaluation and became seizure free after anterior temporal lobectomy (ATL). Simultaneous MEG and scalp EEG were recorded before and 6-12 months after surgery using a whole-scalp neuromagnetometer. We visually searched interictal spikes simultaneously occurring on both MEG and EEG channels and analyzed the spikes by MEG dipole modeling. Results: Spikes were localized in anterior temporal region, although most spikes were not exactly located in mesial temporal structure. The dipole orientation was horizontal for 86% (83-94%) of interictal spikes in 4 patients and vertical for 86% of interictal spikes in 1 patient. According to the postoperative MR images with superimposed spike coordinates, 91% (68- 100%) of preoperative spike dipoles were situated within the resection demarcation of ATL. Conclusions: In patients with mesial TLE, most interictal spikes were localized in anterior temporal lobe within the resection demarcation of ATL. The dipole orientation can be either horizontal or vertical.

Original languageEnglish
Pages (from-to)15-23
Number of pages9
JournalActa Neurologica Taiwanica
Volume12
Issue number1
Publication statusPublished - Mar 1 2003
Externally publishedYes

Fingerprint

Temporal Lobe Epilepsy
Magnetoencephalography
Anterior Temporal Lobectomy
Temporal Lobe
Scalp
Electroencephalography
Seizures

Keywords

  • Interictal spikes
  • Magnetoencephalography
  • Mesial temporal lobe epilepsy
  • Source localization
  • Temporal lobectomy

ASJC Scopus subject areas

  • Neurology
  • Clinical Neurology

Cite this

Lin, Y. Y., Yiu, C. H., Yu, H. Y., Hsieh, J. C., Kwan, S. Y., Yen, D. J., ... Wong, T-T. (2003). Magnetoencephalographic characteristics of interictal spikes in TLE. Acta Neurologica Taiwanica, 12(1), 15-23.

Magnetoencephalographic characteristics of interictal spikes in TLE. / Lin, Yung Yang; Yiu, Chun Hing; Yu, Hsiang Yu; Hsieh, Jen Chuen; Kwan, Shang Yeong; Yen, Der Jen; Chang, Kai Ping; Shih, Yang Hsih; Wong, Tai-Tong.

In: Acta Neurologica Taiwanica, Vol. 12, No. 1, 01.03.2003, p. 15-23.

Research output: Contribution to journalArticle

Lin, YY, Yiu, CH, Yu, HY, Hsieh, JC, Kwan, SY, Yen, DJ, Chang, KP, Shih, YH & Wong, T-T 2003, 'Magnetoencephalographic characteristics of interictal spikes in TLE', Acta Neurologica Taiwanica, vol. 12, no. 1, pp. 15-23.
Lin YY, Yiu CH, Yu HY, Hsieh JC, Kwan SY, Yen DJ et al. Magnetoencephalographic characteristics of interictal spikes in TLE. Acta Neurologica Taiwanica. 2003 Mar 1;12(1):15-23.
Lin, Yung Yang ; Yiu, Chun Hing ; Yu, Hsiang Yu ; Hsieh, Jen Chuen ; Kwan, Shang Yeong ; Yen, Der Jen ; Chang, Kai Ping ; Shih, Yang Hsih ; Wong, Tai-Tong. / Magnetoencephalographic characteristics of interictal spikes in TLE. In: Acta Neurologica Taiwanica. 2003 ; Vol. 12, No. 1. pp. 15-23.
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