Magnesium supplement promotes sciatic nerve regeneration and down-regulates inflammatory response

Hung Chuan Pan, Meei Ling Sheu, Hong Lin Su, Ying Ju Chen, Chun Jung Chen, Dar Yu Yang, Wen Ta Chiu, Fu Chou Cheng

Research output: Contribution to journalArticle

15 Citations (Scopus)

Abstract

Magnesium (Mg) supplements have been shown to significantly improve functional recovery in various neurological disorders. The essential benefits of Mg supplementation in peripheral nerve disorders have not been elucidated yet. The effect and mechanism of Mg supplementation on a sciatic nerve crush injury model was investigated. Sciatic nerve injury was induced in mice by crushing the left sciatic nerve. Mice were randomly divided into three groups with low-, basal- or high-Mg diets (corresponding to 10, 100 or 200%Mgof the basal diet). Neurobehavioral, electrophysiological and regeneration marker studies were conducted to explore nerve regeneration. First, a high Mg diet significantly increased plasma and nerve tissue Mg concentrations. In addition, Mg supplementation improved neurobehavioral, electrophysiological functions, enhanced regeneration marker, and reduced deposits of inflammatory cells as well as expression of inflammatory cytokines. Furthermore, reduced Schwann cell apoptosis was in line with the significant expression of bcl-2, bcl-X L and down-regulated expression of active caspase-3 and cytochrome C. In summary, improved neurological function recovery and enhanced nerve regeneration were found in mice with a sciatic nerve injury that were fed a high- Mg diet, and Schwann cells may have been rescued from apoptosis by the suppression of inflammatory responses.

Original languageEnglish
Pages (from-to)54-70
Number of pages17
JournalMagnesium Research
Volume24
Issue number2
DOIs
Publication statusPublished - Jun 2011

Fingerprint

Nerve Regeneration
Sciatic Nerve
Magnesium
Down-Regulation
Nutrition
Diet
Schwann Cells
Regeneration
Cells
Apoptosis
Nerve Crush
Recovery
Nerve Tissue
Recovery of Function
Wounds and Injuries
Crushing
Cytochromes
Nervous System Diseases
Peripheral Nerves
Caspase 3

Keywords

  • Cytokines
  • Inflammation
  • Magnesium
  • Nerve regeneration
  • Sciatic nerve injury

ASJC Scopus subject areas

  • Biochemistry
  • Clinical Biochemistry

Cite this

Pan, H. C., Sheu, M. L., Su, H. L., Chen, Y. J., Chen, C. J., Yang, D. Y., ... Cheng, F. C. (2011). Magnesium supplement promotes sciatic nerve regeneration and down-regulates inflammatory response. Magnesium Research, 24(2), 54-70. https://doi.org/10.1684/mrh.2011.0280

Magnesium supplement promotes sciatic nerve regeneration and down-regulates inflammatory response. / Pan, Hung Chuan; Sheu, Meei Ling; Su, Hong Lin; Chen, Ying Ju; Chen, Chun Jung; Yang, Dar Yu; Chiu, Wen Ta; Cheng, Fu Chou.

In: Magnesium Research, Vol. 24, No. 2, 06.2011, p. 54-70.

Research output: Contribution to journalArticle

Pan, Hung Chuan ; Sheu, Meei Ling ; Su, Hong Lin ; Chen, Ying Ju ; Chen, Chun Jung ; Yang, Dar Yu ; Chiu, Wen Ta ; Cheng, Fu Chou. / Magnesium supplement promotes sciatic nerve regeneration and down-regulates inflammatory response. In: Magnesium Research. 2011 ; Vol. 24, No. 2. pp. 54-70.
@article{e3339b25ebae4d06a73136fe363efc56,
title = "Magnesium supplement promotes sciatic nerve regeneration and down-regulates inflammatory response",
abstract = "Magnesium (Mg) supplements have been shown to significantly improve functional recovery in various neurological disorders. The essential benefits of Mg supplementation in peripheral nerve disorders have not been elucidated yet. The effect and mechanism of Mg supplementation on a sciatic nerve crush injury model was investigated. Sciatic nerve injury was induced in mice by crushing the left sciatic nerve. Mice were randomly divided into three groups with low-, basal- or high-Mg diets (corresponding to 10, 100 or 200{\%}Mgof the basal diet). Neurobehavioral, electrophysiological and regeneration marker studies were conducted to explore nerve regeneration. First, a high Mg diet significantly increased plasma and nerve tissue Mg concentrations. In addition, Mg supplementation improved neurobehavioral, electrophysiological functions, enhanced regeneration marker, and reduced deposits of inflammatory cells as well as expression of inflammatory cytokines. Furthermore, reduced Schwann cell apoptosis was in line with the significant expression of bcl-2, bcl-X L and down-regulated expression of active caspase-3 and cytochrome C. In summary, improved neurological function recovery and enhanced nerve regeneration were found in mice with a sciatic nerve injury that were fed a high- Mg diet, and Schwann cells may have been rescued from apoptosis by the suppression of inflammatory responses.",
keywords = "Cytokines, Inflammation, Magnesium, Nerve regeneration, Sciatic nerve injury",
author = "Pan, {Hung Chuan} and Sheu, {Meei Ling} and Su, {Hong Lin} and Chen, {Ying Ju} and Chen, {Chun Jung} and Yang, {Dar Yu} and Chiu, {Wen Ta} and Cheng, {Fu Chou}",
year = "2011",
month = "6",
doi = "10.1684/mrh.2011.0280",
language = "English",
volume = "24",
pages = "54--70",
journal = "Magnesium Research",
issn = "0953-1424",
publisher = "John Libbey Eurotext",
number = "2",

}

TY - JOUR

T1 - Magnesium supplement promotes sciatic nerve regeneration and down-regulates inflammatory response

AU - Pan, Hung Chuan

AU - Sheu, Meei Ling

AU - Su, Hong Lin

AU - Chen, Ying Ju

AU - Chen, Chun Jung

AU - Yang, Dar Yu

AU - Chiu, Wen Ta

AU - Cheng, Fu Chou

PY - 2011/6

Y1 - 2011/6

N2 - Magnesium (Mg) supplements have been shown to significantly improve functional recovery in various neurological disorders. The essential benefits of Mg supplementation in peripheral nerve disorders have not been elucidated yet. The effect and mechanism of Mg supplementation on a sciatic nerve crush injury model was investigated. Sciatic nerve injury was induced in mice by crushing the left sciatic nerve. Mice were randomly divided into three groups with low-, basal- or high-Mg diets (corresponding to 10, 100 or 200%Mgof the basal diet). Neurobehavioral, electrophysiological and regeneration marker studies were conducted to explore nerve regeneration. First, a high Mg diet significantly increased plasma and nerve tissue Mg concentrations. In addition, Mg supplementation improved neurobehavioral, electrophysiological functions, enhanced regeneration marker, and reduced deposits of inflammatory cells as well as expression of inflammatory cytokines. Furthermore, reduced Schwann cell apoptosis was in line with the significant expression of bcl-2, bcl-X L and down-regulated expression of active caspase-3 and cytochrome C. In summary, improved neurological function recovery and enhanced nerve regeneration were found in mice with a sciatic nerve injury that were fed a high- Mg diet, and Schwann cells may have been rescued from apoptosis by the suppression of inflammatory responses.

AB - Magnesium (Mg) supplements have been shown to significantly improve functional recovery in various neurological disorders. The essential benefits of Mg supplementation in peripheral nerve disorders have not been elucidated yet. The effect and mechanism of Mg supplementation on a sciatic nerve crush injury model was investigated. Sciatic nerve injury was induced in mice by crushing the left sciatic nerve. Mice were randomly divided into three groups with low-, basal- or high-Mg diets (corresponding to 10, 100 or 200%Mgof the basal diet). Neurobehavioral, electrophysiological and regeneration marker studies were conducted to explore nerve regeneration. First, a high Mg diet significantly increased plasma and nerve tissue Mg concentrations. In addition, Mg supplementation improved neurobehavioral, electrophysiological functions, enhanced regeneration marker, and reduced deposits of inflammatory cells as well as expression of inflammatory cytokines. Furthermore, reduced Schwann cell apoptosis was in line with the significant expression of bcl-2, bcl-X L and down-regulated expression of active caspase-3 and cytochrome C. In summary, improved neurological function recovery and enhanced nerve regeneration were found in mice with a sciatic nerve injury that were fed a high- Mg diet, and Schwann cells may have been rescued from apoptosis by the suppression of inflammatory responses.

KW - Cytokines

KW - Inflammation

KW - Magnesium

KW - Nerve regeneration

KW - Sciatic nerve injury

UR - http://www.scopus.com/inward/record.url?scp=79960996097&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=79960996097&partnerID=8YFLogxK

U2 - 10.1684/mrh.2011.0280

DO - 10.1684/mrh.2011.0280

M3 - Article

C2 - 21609904

AN - SCOPUS:79960996097

VL - 24

SP - 54

EP - 70

JO - Magnesium Research

JF - Magnesium Research

SN - 0953-1424

IS - 2

ER -