Abstract
The aim of this study was to estimate the prevalence of macrolide-resistant Mycoplasma pneumoniae in Taiwan and to compare the clinical courses of pediatric patients with macrolide-resistant (MR) M. pneumoniae and macrolide-susceptible (MS) M. pneumoniae infection. Patients were among the children admitted to Chang Gung Children's Hospital with mycoplasmal pneumonia between February and December 2011. Detection for macrolide resistance was performed after informed consent was obtained. We retrospectively reviewed medical records and compared the clinical courses of two groups of patients of 73 children enrolled into our study. The rate of macrolide resistance in M. pneumoniae was 12.3 %. Longer hospital stay was observed in the MR patients than MS patients [median, 7 days vs. 5 days (P = 0.019)]. Clinical features or radiographic or laboratory findings are not helpful to differentiate MR from MS mycoplasmal pneumonia. Early diagnosis of MR mycoplasmal pneumonia is crucial for the best management of these patients and obviates the need for extensive etiological searches of these nonresponding cases.
| Original language | English |
|---|---|
| Pages (from-to) | 782-786 |
| Number of pages | 5 |
| Journal | Journal of Infection and Chemotherapy |
| Volume | 19 |
| Issue number | 4 |
| DOIs | |
| Publication status | Published - Aug 2013 |
| Externally published | Yes |
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Keywords
- 23s rRNA
- Gene mutation
- Macrolide resistance
- Mycoplasma pneumoniae
- Pneumonia
ASJC Scopus subject areas
- Microbiology (medical)
- Pharmacology (medical)
- Infectious Diseases
Cite this
Macrolide-resistant Mycoplasma pneumoniae in children in Taiwan. / Wu, Han Meng; Wong, Kin Sun; Huang, Yhu Chering; Lai, Shen Hao; Tsao, Kuo Chien; Lin, Ya Jhu; Lin, Tzou Yien.
In: Journal of Infection and Chemotherapy, Vol. 19, No. 4, 08.2013, p. 782-786.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Macrolide-resistant Mycoplasma pneumoniae in children in Taiwan
AU - Wu, Han Meng
AU - Wong, Kin Sun
AU - Huang, Yhu Chering
AU - Lai, Shen Hao
AU - Tsao, Kuo Chien
AU - Lin, Ya Jhu
AU - Lin, Tzou Yien
PY - 2013/8
Y1 - 2013/8
N2 - The aim of this study was to estimate the prevalence of macrolide-resistant Mycoplasma pneumoniae in Taiwan and to compare the clinical courses of pediatric patients with macrolide-resistant (MR) M. pneumoniae and macrolide-susceptible (MS) M. pneumoniae infection. Patients were among the children admitted to Chang Gung Children's Hospital with mycoplasmal pneumonia between February and December 2011. Detection for macrolide resistance was performed after informed consent was obtained. We retrospectively reviewed medical records and compared the clinical courses of two groups of patients of 73 children enrolled into our study. The rate of macrolide resistance in M. pneumoniae was 12.3 %. Longer hospital stay was observed in the MR patients than MS patients [median, 7 days vs. 5 days (P = 0.019)]. Clinical features or radiographic or laboratory findings are not helpful to differentiate MR from MS mycoplasmal pneumonia. Early diagnosis of MR mycoplasmal pneumonia is crucial for the best management of these patients and obviates the need for extensive etiological searches of these nonresponding cases.
AB - The aim of this study was to estimate the prevalence of macrolide-resistant Mycoplasma pneumoniae in Taiwan and to compare the clinical courses of pediatric patients with macrolide-resistant (MR) M. pneumoniae and macrolide-susceptible (MS) M. pneumoniae infection. Patients were among the children admitted to Chang Gung Children's Hospital with mycoplasmal pneumonia between February and December 2011. Detection for macrolide resistance was performed after informed consent was obtained. We retrospectively reviewed medical records and compared the clinical courses of two groups of patients of 73 children enrolled into our study. The rate of macrolide resistance in M. pneumoniae was 12.3 %. Longer hospital stay was observed in the MR patients than MS patients [median, 7 days vs. 5 days (P = 0.019)]. Clinical features or radiographic or laboratory findings are not helpful to differentiate MR from MS mycoplasmal pneumonia. Early diagnosis of MR mycoplasmal pneumonia is crucial for the best management of these patients and obviates the need for extensive etiological searches of these nonresponding cases.
KW - 23s rRNA
KW - Gene mutation
KW - Macrolide resistance
KW - Mycoplasma pneumoniae
KW - Pneumonia
UR - http://www.scopus.com/inward/record.url?scp=84882289486&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=84882289486&partnerID=8YFLogxK
U2 - 10.1007/s10156-012-0523-3
DO - 10.1007/s10156-012-0523-3
M3 - Article
VL - 19
SP - 782
EP - 786
JO - Journal of Infection and Chemotherapy
JF - Journal of Infection and Chemotherapy
SN - 1341-321X
IS - 4
ER -