Lymphoepithelioma-like cholangiocarcinoma: An Epstein-Barr virus-associated tumor

Yung Ming Jeng, Chi Long Chen, Hey C. Hsu

Research output: Contribution to journalArticlepeer-review

52 Citations (Scopus)

Abstract

Epstein-Barr virus (EBV) has been linked to carcinomas of several body sites, especially of the nasopharynx, salivary gland, lung, and stomach. We present five cases of lymphoepithelioma-like cholangiocarcinoma, including one that had been previously reported. Two patients were men and three were women. Their ages ranged from 42 to 66 years. Histologically, all five tumors were composed of variable proportions of undifferentiated epithelial cells and glandular components in a lymphocyte-rich stroma. EBV was detected in all five tumors by in situ hybridization for EBER-1 in both lymphoepithelioma-like carcinoma (LELC) and glandular parts, but not in 36 cases of cholangiocarcinoma without the LELC component. Taken together, these observations indicate that lymphoepithelioma-like cholangiocarcinoma is strongly linked to EBV. The LELC type of cholangiocarcinoma, like LELC of other body sites, may be more common in areas with endemic EBV infection.

Original languageEnglish
Pages (from-to)516-520
Number of pages5
JournalAmerican Journal of Surgical Pathology
Volume25
Issue number4
DOIs
Publication statusPublished - 2001
Externally publishedYes

Keywords

  • Cholangiocarcinoma
  • Epstein-Barr virus
  • In situ hybridization.
  • Lymphoepithelioma

ASJC Scopus subject areas

  • Anatomy
  • Pathology and Forensic Medicine

Fingerprint Dive into the research topics of 'Lymphoepithelioma-like cholangiocarcinoma: An Epstein-Barr virus-associated tumor'. Together they form a unique fingerprint.

Cite this