Abstract

Lupus pneumonitis carries high mortality and is a rare manifestation of systemic lupus erythematosus (SLE). However, it is difficult to diagnose and is often mistaken as pneumonia, alveolar haemorrhage, or organizing pneumonia. Previous studies demonstrated that serum anti-Ro antibodies are elevated more frequently in SLE patients with pneumonitis than in those without. We report a 21-year-old female who was newly diagnosed as having SLE with nephritis and who suddenly developed right lung opacity and rapidly progressed to severe hypoxaemia despite the use of broad-spectrum antibiotics. The serum titre of anti-Ro antibody was greater than 240 U/mL. She underwent lung biopsy and lupus pneumonitis was confirmed by the pathological findings. Subsequently, she showed a favourable response to plasma exchange, steroid pulse therapy, and mycophenolate mofetil (MMF) treatment. For SLE patients with pulmonary infiltrates, high degree of clinical suspicion of lupus pneumonitis is required and measurement of serum anti-Ro antibody may help to make the diagnosis.

Original languageEnglish
Article numbere00280
JournalRespirology Case Reports
Volume6
Issue number1
DOIs
Publication statusPublished - Jan 1 2018

Fingerprint

Anti-Idiotypic Antibodies
Pneumonia
Systemic Lupus Erythematosus
Lung
Serum
Mycophenolic Acid
Plasma Exchange
Nephritis
SS-A antibodies
Steroids
Hemorrhage
Anti-Bacterial Agents
Biopsy
Mortality
Therapeutics

Keywords

  • Anti-Ro antibody
  • Lupus pneumonitis
  • Systemic lupus erythematosus

ASJC Scopus subject areas

  • Pulmonary and Respiratory Medicine

Cite this

Lupus pneumonitis presenting with high titre of anti-ro antibody. / Chen, Mei Chuan; Wu, Yueh Lin; Lee, Kai Ling; Lai, Kevin S.; Chung, Chi Li.

In: Respirology Case Reports, Vol. 6, No. 1, e00280, 01.01.2018.

Research output: Contribution to journalArticle

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N2 - Lupus pneumonitis carries high mortality and is a rare manifestation of systemic lupus erythematosus (SLE). However, it is difficult to diagnose and is often mistaken as pneumonia, alveolar haemorrhage, or organizing pneumonia. Previous studies demonstrated that serum anti-Ro antibodies are elevated more frequently in SLE patients with pneumonitis than in those without. We report a 21-year-old female who was newly diagnosed as having SLE with nephritis and who suddenly developed right lung opacity and rapidly progressed to severe hypoxaemia despite the use of broad-spectrum antibiotics. The serum titre of anti-Ro antibody was greater than 240 U/mL. She underwent lung biopsy and lupus pneumonitis was confirmed by the pathological findings. Subsequently, she showed a favourable response to plasma exchange, steroid pulse therapy, and mycophenolate mofetil (MMF) treatment. For SLE patients with pulmonary infiltrates, high degree of clinical suspicion of lupus pneumonitis is required and measurement of serum anti-Ro antibody may help to make the diagnosis.

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