Lung volume, dynamic lung compliance, and blood gases during the first 3 days of postnatal life in infants with meconium aspiration syndrome.

T. F. Yeh, L. D. Lilien, A. Barathi, R. S. Pildes

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Abstract

Serial measurements of pulmonary function and arterial blood gases during the first 3 postnatal days of life were obtained in 12 infants with meconium aspiration syndrome (MAS). Nine normal neonates with similar weight and gestational age were studied as controls. Infants with MAS has significantly lower pH on day 1, and had greater P(A-a)O2 throughout the study period than that of normal controls. The PCO2 was comparable between the groups. Both dynamic lung compliance (Cdyn) and specific lung compliance (C/VL) were lower in infants with MAS as compared with those of normal infants. The functional residual capacity (FRC) for normal infants on days 1, 2, and 3 were 2.0 +/- 0.3, 2.1 +/- 0.3, and 2.2 +/- 0.3 ml/cm, respectively, and for infants with MAS were 1.8 +/- 0.4, 2.3 +!- 1.1, and 2.2 +/- 0.6 ml/cm, respectively. Radiographic hyperinflation of the lungs was seen in 6 infants with MAS on day 1; 3 were associated with high FRC (greater than 2 SD of normal) and 2 with low FRC, indicating air trapping. The early use of PEEP should be cautious if hyperinflation or air trapping is present.

Original languageEnglish
Pages (from-to)588-592
Number of pages5
JournalCritical Care Medicine
Volume10
Issue number9
DOIs
Publication statusPublished - Jan 1 1982

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Meconium Aspiration Syndrome
Lung Compliance
Gases
Lung
Functional Residual Capacity
Air
Gestational Age
Newborn Infant
Weights and Measures

ASJC Scopus subject areas

  • Critical Care and Intensive Care Medicine

Cite this

Lung volume, dynamic lung compliance, and blood gases during the first 3 days of postnatal life in infants with meconium aspiration syndrome. / Yeh, T. F.; Lilien, L. D.; Barathi, A.; Pildes, R. S.

In: Critical Care Medicine, Vol. 10, No. 9, 01.01.1982, p. 588-592.

Research output: Contribution to journalArticle

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