Lung cancer susceptibility and genetic polymorphisms of Exo1 gene in Taiwan

N. Y. Hsu, Hwei Chung Wang, Chung Hsing Wang, Chang Fang Chiu, Hsien Chang Tseng, Shiu Yun Liang, Chia Wen Tsai, Cheng Chieh Lin, Da Tian Bau

Research output: Contribution to journalArticle

32 Citations (Scopus)

Abstract

Aim: To evaluate the association between the polymorphisms of the Exol gene and the risk of lung cancer in central Taiwan. Patients and Methods: In this hospital-based study, the association of Exol A-1419G (rs3754093), C-908G (rs10802996), A238G (rs1776177), C498T (rs1635517), K589E (rs1047840), G670E (rs1776148), C723R (rs1635498), L757P (rs9350) and C3114T (rs851797) polymorphisms with lung cancer risk in a central Taiwanese population was investigated. In total, 358 patients with lung cancer and 358 age- and gender-matched healthy controls recruited from the China Medical Hospital in central Taiwan were genotyped. Results: A significantly different distribution was found in the frequency of the Exol K589E genotype, but not the other genotypes, between the lung cancer and control groups. The A allele Exo1 K589E conferred a significantly (p=0.0097) increased risk of lung cancer. As for the rest of the polymorphisms, there was no difference in distribution between the lung cancer and control groups. Gene environment interactions with smoking were significant for Exo1 K589E polymorphism. The Exo1 K589E AG and AA genotype in association with smoking conferred an increased risk of 1.7208 (95% confidence interval=1.2188-2.4295) for lung cancer. Conclusion: Our results provide the first evidence that the A allele of Exo1 K589E may be associated with the development of lung cancer and may be a novel useful marker for primary prevention and anticancer intervention.

Original languageEnglish
Pages (from-to)725-730
Number of pages6
JournalAnticancer Research
Volume29
Issue number2
Publication statusPublished - Feb 2009
Externally publishedYes

Keywords

  • Carcinogenesis
  • Exo1
  • Lung cancer
  • Polymorphism

ASJC Scopus subject areas

  • Cancer Research
  • Oncology

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  • Cite this

    Hsu, N. Y., Wang, H. C., Wang, C. H., Chiu, C. F., Tseng, H. C., Liang, S. Y., Tsai, C. W., Lin, C. C., & Bau, D. T. (2009). Lung cancer susceptibility and genetic polymorphisms of Exo1 gene in Taiwan. Anticancer Research, 29(2), 725-730.