Lung cancer susceptibility and genetic polymorphism of DNA repair gene XRCC4 in Taiwan

Nan Yung Hsu, Hwei Chung Wang, Chung Hsing Wang, Chia Lin Chang, Chang Fang Chiu, Hong Zin Lee, Chia Wen Tsai, Da Tian Bau

Research output: Contribution to journalArticle

27 Citations (Scopus)

Abstract

Non-homologous end-joining (NHEJ) system is a major route in repairing double strand breaks (DSBs), and is important in maintaining the genome stability. The gene XRCC4 is a central role of the NHEJ system, and it is critical in carcinogenesis. In order to reveal the association between XRCC4 and lung cancer, we recruited 164 lung cancer patients and 649 healthy controls from central Taiwan, investigated seven novel polymorphic variants of XRCC4, includes C-1622T (rs7727691), G-1394T (rs6869366), G-652T (rs2075685), C-571T (rs2075686), intron3 DIP (rs28360071), S247A (rs3734091) and intron7 DIP (rs28360317), and analyzed the association of specific genotype with lung cancer susceptibility. The results showed that the XRCC4 G-1394T is significant in Taiwanese lung cancer and the GT genotype of G-1394T is an obvious risk factor of lung cancer susceptibility (P = 0.0049), and the G allele is a risky factor (P = 0.0087). As for XRCC4 C-1622T (rs7727691), G-652T (rs2075685), C-571T (rs2075686), intron3 DIP (rs28360071), S247A (rs3734091) and intron7 DIP (rs28360317) polymorphism sites, there was no difference in the distribution between the lung cancer and control groups. The analyzing results of joint effect for smoking habit and XRCC4 G-1394T polymorphism was that people with GT genotype and smoking habit present the highest risk of lung cancer than other groups (OR = 2.31, 95% CI = 1.43-3.72). The G allele of the XRCC4 G-1394T may be responsible for lung carcinogenesis and maybe useful in early detection and prevention of lung cancer.

Original languageEnglish
Pages (from-to)159-165
Number of pages7
JournalCancer Biomarkers
Volume5
Issue number4-5
DOIs
Publication statusPublished - 2009
Externally publishedYes

Fingerprint

Genetic Polymorphisms
Taiwan
DNA Repair
Lung Neoplasms
Genes
Genotype
Habits
Carcinogenesis
Smoking
Alleles
Genomic Instability
Lung
Control Groups

Keywords

  • Carcinogenesis
  • Lung cancer
  • Polymorphism
  • XRCC4

ASJC Scopus subject areas

  • Cancer Research
  • Oncology
  • Genetics

Cite this

Hsu, N. Y., Wang, H. C., Wang, C. H., Chang, C. L., Chiu, C. F., Lee, H. Z., ... Bau, D. T. (2009). Lung cancer susceptibility and genetic polymorphism of DNA repair gene XRCC4 in Taiwan. Cancer Biomarkers, 5(4-5), 159-165. https://doi.org/10.3233/CBM-2009-0617

Lung cancer susceptibility and genetic polymorphism of DNA repair gene XRCC4 in Taiwan. / Hsu, Nan Yung; Wang, Hwei Chung; Wang, Chung Hsing; Chang, Chia Lin; Chiu, Chang Fang; Lee, Hong Zin; Tsai, Chia Wen; Bau, Da Tian.

In: Cancer Biomarkers, Vol. 5, No. 4-5, 2009, p. 159-165.

Research output: Contribution to journalArticle

Hsu, NY, Wang, HC, Wang, CH, Chang, CL, Chiu, CF, Lee, HZ, Tsai, CW & Bau, DT 2009, 'Lung cancer susceptibility and genetic polymorphism of DNA repair gene XRCC4 in Taiwan', Cancer Biomarkers, vol. 5, no. 4-5, pp. 159-165. https://doi.org/10.3233/CBM-2009-0617
Hsu, Nan Yung ; Wang, Hwei Chung ; Wang, Chung Hsing ; Chang, Chia Lin ; Chiu, Chang Fang ; Lee, Hong Zin ; Tsai, Chia Wen ; Bau, Da Tian. / Lung cancer susceptibility and genetic polymorphism of DNA repair gene XRCC4 in Taiwan. In: Cancer Biomarkers. 2009 ; Vol. 5, No. 4-5. pp. 159-165.
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AU - Tsai, Chia Wen

AU - Bau, Da Tian

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AB - Non-homologous end-joining (NHEJ) system is a major route in repairing double strand breaks (DSBs), and is important in maintaining the genome stability. The gene XRCC4 is a central role of the NHEJ system, and it is critical in carcinogenesis. In order to reveal the association between XRCC4 and lung cancer, we recruited 164 lung cancer patients and 649 healthy controls from central Taiwan, investigated seven novel polymorphic variants of XRCC4, includes C-1622T (rs7727691), G-1394T (rs6869366), G-652T (rs2075685), C-571T (rs2075686), intron3 DIP (rs28360071), S247A (rs3734091) and intron7 DIP (rs28360317), and analyzed the association of specific genotype with lung cancer susceptibility. The results showed that the XRCC4 G-1394T is significant in Taiwanese lung cancer and the GT genotype of G-1394T is an obvious risk factor of lung cancer susceptibility (P = 0.0049), and the G allele is a risky factor (P = 0.0087). As for XRCC4 C-1622T (rs7727691), G-652T (rs2075685), C-571T (rs2075686), intron3 DIP (rs28360071), S247A (rs3734091) and intron7 DIP (rs28360317) polymorphism sites, there was no difference in the distribution between the lung cancer and control groups. The analyzing results of joint effect for smoking habit and XRCC4 G-1394T polymorphism was that people with GT genotype and smoking habit present the highest risk of lung cancer than other groups (OR = 2.31, 95% CI = 1.43-3.72). The G allele of the XRCC4 G-1394T may be responsible for lung carcinogenesis and maybe useful in early detection and prevention of lung cancer.

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