Lung cancer model on chip for drug testing

Kuo Wei Chang, Tushar Harishchandra Punde, Gaurav Prashant Pendharkar, Po Chen Shih, Yao Fei Chan, Kang Yun Lee, Ming Yan Chen, Cheng Hsien Liu

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Abstract

In this paper we have simulated an in vitro lung cancer microenvironment by dielectrophoresis (DEP) patterning. Heterogeneous cells were patterned on the glass substrate, above which a microfluidic gradient is integrated to generate different concentration of target therapy drug (Iressa). Taking advantage of DEP pattern and microfluidic gradient, we designed a biochip to mimic the in vivo conditions. The influence of drug treatment for cell patterning is better than the non-patterned case as visualized in cell viability rate by MTT assay.

Original languageEnglish
Title of host publication2015 Transducers - 2015 18th International Conference on Solid-State Sensors, Actuators and Microsystems, TRANSDUCERS 2015
PublisherInstitute of Electrical and Electronics Engineers Inc.
Pages646-649
Number of pages4
ISBN (Print)9781479989553
DOIs
Publication statusPublished - Aug 5 2015
Event18th International Conference on Solid-State Sensors, Actuators and Microsystems, TRANSDUCERS 2015 - Anchorage, United States
Duration: Jun 21 2015Jun 25 2015

Other

Other18th International Conference on Solid-State Sensors, Actuators and Microsystems, TRANSDUCERS 2015
CountryUnited States
CityAnchorage
Period6/21/156/25/15

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Keywords

  • Dielectrophoresis
  • Gradient Microchannel
  • Lung Cancer Patterned
  • Target Therapy Drug

ASJC Scopus subject areas

  • Instrumentation
  • Electrical and Electronic Engineering

Cite this

Chang, K. W., Punde, T. H., Pendharkar, G. P., Shih, P. C., Chan, Y. F., Lee, K. Y., Chen, M. Y., & Liu, C. H. (2015). Lung cancer model on chip for drug testing. In 2015 Transducers - 2015 18th International Conference on Solid-State Sensors, Actuators and Microsystems, TRANSDUCERS 2015 (pp. 646-649). [7181006] Institute of Electrical and Electronics Engineers Inc.. https://doi.org/10.1109/TRANSDUCERS.2015.7181006