Low value of [18F]-fluoro-2-deoxy-D-glucose positron emission tomography in primary staging of early-stage cervical cancer before radical hysterectomy

Hung Hsueh Chou, Ting Chang Chang, Tzu Chen Yen, Koon Kwan Ng, Swei Hsueh, Shih Ya Ma, Chee Jen Chang, Huei Jean Huang, Angel Chao, Tzu I. Wu, Shih Ming Jung, Yen Ching Wu, Cheng Tao Lin, Kuan Gen Huang, Chyong Huey Lai

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Abstract

Purpose: The role of positron emission tomography (PET) with [ 18F]-fluoro-2-deoxy-D-glucose (FDG) in early-stage cervical cancer is unclear. We aimed to investigate the clinical benefit of FDG-PET in primary staging before radical hysterectomy and pelvic lymphadenectomy (RH-PLND). Patients and Methods: Patients with untreated stage IA2 to IIA adenocarcinoma (AD) or adenosquamous carcinoma (ASC) or nonbulky (≤ 4 cm) squamous cell carcinoma cervical cancer with magnetic resonance imaging (MRI) - defined negative nodal metastasis were enrolled onto a prospective study with a two-stage design. All patients had a preoperative dual-phase FDG-PET, technetium-99m-sulfur colloid lymphoscintigraphy, and intraoperative sentinel lymph node (LN) detection at RH-PLND. The gold standard of LN metastasis is histologic. A sample size of 120 patients was calculated to fit study aims (diagnostic efficacy of PET and sentinel LN sampling). An interim analysis was performed when 60 patients were accrued, which led to the current report. Results: There were 36 SCCs, 20 ADs, and four ASCs. Of the 60 patients, 10 (16.7%) had pelvic LN metastases, and one (1.7%) had para-aortic LN (PALN) metastasis histologically. FDG-PET detected the single PALN metastasis (one of one patient) but detected only one (10%) of the 10 pelvic LN metastases. The PET false-negative pelvic LN micrometastases measured a median of 4.0 X 3.0 mm (range, 0.5 X 0.5 to 7 X 6 mm). The second stage of this trial will be continued without PET. Conclusion: This study shows that dual-phase FDG-PET has little value in primary, nonbulky, stage IA2 to IIA and MRI-defined, LN-negative cervical cancer.

Original languageEnglish
Pages (from-to)123-128
Number of pages6
JournalJournal of Clinical Oncology
Volume24
Issue number1
DOIs
Publication statusPublished - Jan 1 2006
Externally publishedYes

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Deoxyglucose
Hysterectomy
Uterine Cervical Neoplasms
Positron-Emission Tomography
Lymph Nodes
Neoplasm Metastasis
Technetium Tc 99m Sulfur Colloid
Magnetic Resonance Imaging
Adenosquamous Carcinoma
Lymphoscintigraphy
Neoplasm Micrometastasis
Technetium
Lymph Node Excision
Sample Size
Squamous Cell Carcinoma
Adenocarcinoma
Prospective Studies

ASJC Scopus subject areas

  • Cancer Research
  • Oncology

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Low value of [18F]-fluoro-2-deoxy-D-glucose positron emission tomography in primary staging of early-stage cervical cancer before radical hysterectomy. / Chou, Hung Hsueh; Chang, Ting Chang; Yen, Tzu Chen; Ng, Koon Kwan; Hsueh, Swei; Ma, Shih Ya; Chang, Chee Jen; Huang, Huei Jean; Chao, Angel; Wu, Tzu I.; Jung, Shih Ming; Wu, Yen Ching; Lin, Cheng Tao; Huang, Kuan Gen; Lai, Chyong Huey.

In: Journal of Clinical Oncology, Vol. 24, No. 1, 01.01.2006, p. 123-128.

Research output: Contribution to journalArticle

Chou, HH, Chang, TC, Yen, TC, Ng, KK, Hsueh, S, Ma, SY, Chang, CJ, Huang, HJ, Chao, A, Wu, TI, Jung, SM, Wu, YC, Lin, CT, Huang, KG & Lai, CH 2006, 'Low value of [18F]-fluoro-2-deoxy-D-glucose positron emission tomography in primary staging of early-stage cervical cancer before radical hysterectomy', Journal of Clinical Oncology, vol. 24, no. 1, pp. 123-128. https://doi.org/10.1200/JCO.2005.03.5964
Chou, Hung Hsueh ; Chang, Ting Chang ; Yen, Tzu Chen ; Ng, Koon Kwan ; Hsueh, Swei ; Ma, Shih Ya ; Chang, Chee Jen ; Huang, Huei Jean ; Chao, Angel ; Wu, Tzu I. ; Jung, Shih Ming ; Wu, Yen Ching ; Lin, Cheng Tao ; Huang, Kuan Gen ; Lai, Chyong Huey. / Low value of [18F]-fluoro-2-deoxy-D-glucose positron emission tomography in primary staging of early-stage cervical cancer before radical hysterectomy. In: Journal of Clinical Oncology. 2006 ; Vol. 24, No. 1. pp. 123-128.
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abstract = "Purpose: The role of positron emission tomography (PET) with [ 18F]-fluoro-2-deoxy-D-glucose (FDG) in early-stage cervical cancer is unclear. We aimed to investigate the clinical benefit of FDG-PET in primary staging before radical hysterectomy and pelvic lymphadenectomy (RH-PLND). Patients and Methods: Patients with untreated stage IA2 to IIA adenocarcinoma (AD) or adenosquamous carcinoma (ASC) or nonbulky (≤ 4 cm) squamous cell carcinoma cervical cancer with magnetic resonance imaging (MRI) - defined negative nodal metastasis were enrolled onto a prospective study with a two-stage design. All patients had a preoperative dual-phase FDG-PET, technetium-99m-sulfur colloid lymphoscintigraphy, and intraoperative sentinel lymph node (LN) detection at RH-PLND. The gold standard of LN metastasis is histologic. A sample size of 120 patients was calculated to fit study aims (diagnostic efficacy of PET and sentinel LN sampling). An interim analysis was performed when 60 patients were accrued, which led to the current report. Results: There were 36 SCCs, 20 ADs, and four ASCs. Of the 60 patients, 10 (16.7{\%}) had pelvic LN metastases, and one (1.7{\%}) had para-aortic LN (PALN) metastasis histologically. FDG-PET detected the single PALN metastasis (one of one patient) but detected only one (10{\%}) of the 10 pelvic LN metastases. The PET false-negative pelvic LN micrometastases measured a median of 4.0 X 3.0 mm (range, 0.5 X 0.5 to 7 X 6 mm). The second stage of this trial will be continued without PET. Conclusion: This study shows that dual-phase FDG-PET has little value in primary, nonbulky, stage IA2 to IIA and MRI-defined, LN-negative cervical cancer.",
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T1 - Low value of [18F]-fluoro-2-deoxy-D-glucose positron emission tomography in primary staging of early-stage cervical cancer before radical hysterectomy

AU - Chou, Hung Hsueh

AU - Chang, Ting Chang

AU - Yen, Tzu Chen

AU - Ng, Koon Kwan

AU - Hsueh, Swei

AU - Ma, Shih Ya

AU - Chang, Chee Jen

AU - Huang, Huei Jean

AU - Chao, Angel

AU - Wu, Tzu I.

AU - Jung, Shih Ming

AU - Wu, Yen Ching

AU - Lin, Cheng Tao

AU - Huang, Kuan Gen

AU - Lai, Chyong Huey

PY - 2006/1/1

Y1 - 2006/1/1

N2 - Purpose: The role of positron emission tomography (PET) with [ 18F]-fluoro-2-deoxy-D-glucose (FDG) in early-stage cervical cancer is unclear. We aimed to investigate the clinical benefit of FDG-PET in primary staging before radical hysterectomy and pelvic lymphadenectomy (RH-PLND). Patients and Methods: Patients with untreated stage IA2 to IIA adenocarcinoma (AD) or adenosquamous carcinoma (ASC) or nonbulky (≤ 4 cm) squamous cell carcinoma cervical cancer with magnetic resonance imaging (MRI) - defined negative nodal metastasis were enrolled onto a prospective study with a two-stage design. All patients had a preoperative dual-phase FDG-PET, technetium-99m-sulfur colloid lymphoscintigraphy, and intraoperative sentinel lymph node (LN) detection at RH-PLND. The gold standard of LN metastasis is histologic. A sample size of 120 patients was calculated to fit study aims (diagnostic efficacy of PET and sentinel LN sampling). An interim analysis was performed when 60 patients were accrued, which led to the current report. Results: There were 36 SCCs, 20 ADs, and four ASCs. Of the 60 patients, 10 (16.7%) had pelvic LN metastases, and one (1.7%) had para-aortic LN (PALN) metastasis histologically. FDG-PET detected the single PALN metastasis (one of one patient) but detected only one (10%) of the 10 pelvic LN metastases. The PET false-negative pelvic LN micrometastases measured a median of 4.0 X 3.0 mm (range, 0.5 X 0.5 to 7 X 6 mm). The second stage of this trial will be continued without PET. Conclusion: This study shows that dual-phase FDG-PET has little value in primary, nonbulky, stage IA2 to IIA and MRI-defined, LN-negative cervical cancer.

AB - Purpose: The role of positron emission tomography (PET) with [ 18F]-fluoro-2-deoxy-D-glucose (FDG) in early-stage cervical cancer is unclear. We aimed to investigate the clinical benefit of FDG-PET in primary staging before radical hysterectomy and pelvic lymphadenectomy (RH-PLND). Patients and Methods: Patients with untreated stage IA2 to IIA adenocarcinoma (AD) or adenosquamous carcinoma (ASC) or nonbulky (≤ 4 cm) squamous cell carcinoma cervical cancer with magnetic resonance imaging (MRI) - defined negative nodal metastasis were enrolled onto a prospective study with a two-stage design. All patients had a preoperative dual-phase FDG-PET, technetium-99m-sulfur colloid lymphoscintigraphy, and intraoperative sentinel lymph node (LN) detection at RH-PLND. The gold standard of LN metastasis is histologic. A sample size of 120 patients was calculated to fit study aims (diagnostic efficacy of PET and sentinel LN sampling). An interim analysis was performed when 60 patients were accrued, which led to the current report. Results: There were 36 SCCs, 20 ADs, and four ASCs. Of the 60 patients, 10 (16.7%) had pelvic LN metastases, and one (1.7%) had para-aortic LN (PALN) metastasis histologically. FDG-PET detected the single PALN metastasis (one of one patient) but detected only one (10%) of the 10 pelvic LN metastases. The PET false-negative pelvic LN micrometastases measured a median of 4.0 X 3.0 mm (range, 0.5 X 0.5 to 7 X 6 mm). The second stage of this trial will be continued without PET. Conclusion: This study shows that dual-phase FDG-PET has little value in primary, nonbulky, stage IA2 to IIA and MRI-defined, LN-negative cervical cancer.

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