Low sex hormone-binding globulin is associated with low high-density lipoprotein cholesterol and metabolic syndrome in women with PCOS

Mei Jou Chen, Wei Shiung Yang, Jehn Hsiahn Yang, Chuhsing Kate Hsiao, Yu Shih Yang, Hong Nerng Ho

Research output: Contribution to journalArticle

57 Citations (Scopus)

Abstract

Background: Decreased high-density lipoprotein cholesterol (HDL-C) and sex hormone-binding globulin (SHBG) levels, and the metabolic syndrome, are all closely associated with a higher prevalence of atherosclerotic cardiovascular disease. We investigated the association between HDL-C, SHBG and the metabolic syndrome in women with polycystic ovary syndrome (PCOS). Methods and Results: Among 106 young Taiwanese women (mean age ± SD, 24.9 ± 4.8 years) with PCOS, 69 (65.1%) women had an HDL-C level <50 mg dl-1. The level of HDL-C was highly correlated with that of serum SHBG (γ = 0.6034, P < 0.0001). The SHBG level was significantly lower in subjects with an HDL-C <50 mg dl-1 than that in subjects with an HDL-C ≥50 mg dl-1. Using multiple linear regression models with adjustment for age, BMI and other anthropometric, metabolic, liver function and hormonal variables, we showed serum SHBG to be independently correlated with HDL-C. Based on logistic regression analysis with adjustment for age, the SHBG level was significantly lower in women with PCOS with the metabolic syndrome (odds ratio = 0.92, P = 0.003). Conclusions: Low levels of SHBG in women with PCOS were associated with low levels of HDL-C, independent of insulin resistance and obesity. The SHBG level was inversely related to the occurrence of metabolic syndrome, further strengthening the potential link between SHBG levels and cardiovascular disease in women with PCOS.

Original languageEnglish
Pages (from-to)2266-2271
Number of pages6
JournalHuman Reproduction
Volume21
Issue number9
DOIs
Publication statusPublished - Jan 1 2006
Externally publishedYes

Fingerprint

Sex Hormone-Binding Globulin
Polycystic Ovary Syndrome
LDL Cholesterol
HDL Cholesterol
Cardiovascular Diseases
Serum Globulins
Linear Models
Insulin Resistance
Obesity
Logistic Models
Odds Ratio
Regression Analysis
Liver

Keywords

  • Cardiovascular disease
  • High-density lipoprotein cholesterol
  • Metabolic syndrome
  • PCOS
  • SHBG

ASJC Scopus subject areas

  • Reproductive Medicine
  • Obstetrics and Gynaecology

Cite this

Low sex hormone-binding globulin is associated with low high-density lipoprotein cholesterol and metabolic syndrome in women with PCOS. / Chen, Mei Jou; Yang, Wei Shiung; Yang, Jehn Hsiahn; Hsiao, Chuhsing Kate; Yang, Yu Shih; Ho, Hong Nerng.

In: Human Reproduction, Vol. 21, No. 9, 01.01.2006, p. 2266-2271.

Research output: Contribution to journalArticle

Chen, Mei Jou ; Yang, Wei Shiung ; Yang, Jehn Hsiahn ; Hsiao, Chuhsing Kate ; Yang, Yu Shih ; Ho, Hong Nerng. / Low sex hormone-binding globulin is associated with low high-density lipoprotein cholesterol and metabolic syndrome in women with PCOS. In: Human Reproduction. 2006 ; Vol. 21, No. 9. pp. 2266-2271.
@article{c0d4d5bc5443457697f0dc1115e8647c,
title = "Low sex hormone-binding globulin is associated with low high-density lipoprotein cholesterol and metabolic syndrome in women with PCOS",
abstract = "Background: Decreased high-density lipoprotein cholesterol (HDL-C) and sex hormone-binding globulin (SHBG) levels, and the metabolic syndrome, are all closely associated with a higher prevalence of atherosclerotic cardiovascular disease. We investigated the association between HDL-C, SHBG and the metabolic syndrome in women with polycystic ovary syndrome (PCOS). Methods and Results: Among 106 young Taiwanese women (mean age ± SD, 24.9 ± 4.8 years) with PCOS, 69 (65.1{\%}) women had an HDL-C level <50 mg dl-1. The level of HDL-C was highly correlated with that of serum SHBG (γ = 0.6034, P < 0.0001). The SHBG level was significantly lower in subjects with an HDL-C <50 mg dl-1 than that in subjects with an HDL-C ≥50 mg dl-1. Using multiple linear regression models with adjustment for age, BMI and other anthropometric, metabolic, liver function and hormonal variables, we showed serum SHBG to be independently correlated with HDL-C. Based on logistic regression analysis with adjustment for age, the SHBG level was significantly lower in women with PCOS with the metabolic syndrome (odds ratio = 0.92, P = 0.003). Conclusions: Low levels of SHBG in women with PCOS were associated with low levels of HDL-C, independent of insulin resistance and obesity. The SHBG level was inversely related to the occurrence of metabolic syndrome, further strengthening the potential link between SHBG levels and cardiovascular disease in women with PCOS.",
keywords = "Cardiovascular disease, High-density lipoprotein cholesterol, Metabolic syndrome, PCOS, SHBG",
author = "Chen, {Mei Jou} and Yang, {Wei Shiung} and Yang, {Jehn Hsiahn} and Hsiao, {Chuhsing Kate} and Yang, {Yu Shih} and Ho, {Hong Nerng}",
year = "2006",
month = "1",
day = "1",
doi = "10.1093/humrep/del175",
language = "English",
volume = "21",
pages = "2266--2271",
journal = "Human Reproduction",
issn = "0268-1161",
publisher = "Oxford University Press",
number = "9",

}

TY - JOUR

T1 - Low sex hormone-binding globulin is associated with low high-density lipoprotein cholesterol and metabolic syndrome in women with PCOS

AU - Chen, Mei Jou

AU - Yang, Wei Shiung

AU - Yang, Jehn Hsiahn

AU - Hsiao, Chuhsing Kate

AU - Yang, Yu Shih

AU - Ho, Hong Nerng

PY - 2006/1/1

Y1 - 2006/1/1

N2 - Background: Decreased high-density lipoprotein cholesterol (HDL-C) and sex hormone-binding globulin (SHBG) levels, and the metabolic syndrome, are all closely associated with a higher prevalence of atherosclerotic cardiovascular disease. We investigated the association between HDL-C, SHBG and the metabolic syndrome in women with polycystic ovary syndrome (PCOS). Methods and Results: Among 106 young Taiwanese women (mean age ± SD, 24.9 ± 4.8 years) with PCOS, 69 (65.1%) women had an HDL-C level <50 mg dl-1. The level of HDL-C was highly correlated with that of serum SHBG (γ = 0.6034, P < 0.0001). The SHBG level was significantly lower in subjects with an HDL-C <50 mg dl-1 than that in subjects with an HDL-C ≥50 mg dl-1. Using multiple linear regression models with adjustment for age, BMI and other anthropometric, metabolic, liver function and hormonal variables, we showed serum SHBG to be independently correlated with HDL-C. Based on logistic regression analysis with adjustment for age, the SHBG level was significantly lower in women with PCOS with the metabolic syndrome (odds ratio = 0.92, P = 0.003). Conclusions: Low levels of SHBG in women with PCOS were associated with low levels of HDL-C, independent of insulin resistance and obesity. The SHBG level was inversely related to the occurrence of metabolic syndrome, further strengthening the potential link between SHBG levels and cardiovascular disease in women with PCOS.

AB - Background: Decreased high-density lipoprotein cholesterol (HDL-C) and sex hormone-binding globulin (SHBG) levels, and the metabolic syndrome, are all closely associated with a higher prevalence of atherosclerotic cardiovascular disease. We investigated the association between HDL-C, SHBG and the metabolic syndrome in women with polycystic ovary syndrome (PCOS). Methods and Results: Among 106 young Taiwanese women (mean age ± SD, 24.9 ± 4.8 years) with PCOS, 69 (65.1%) women had an HDL-C level <50 mg dl-1. The level of HDL-C was highly correlated with that of serum SHBG (γ = 0.6034, P < 0.0001). The SHBG level was significantly lower in subjects with an HDL-C <50 mg dl-1 than that in subjects with an HDL-C ≥50 mg dl-1. Using multiple linear regression models with adjustment for age, BMI and other anthropometric, metabolic, liver function and hormonal variables, we showed serum SHBG to be independently correlated with HDL-C. Based on logistic regression analysis with adjustment for age, the SHBG level was significantly lower in women with PCOS with the metabolic syndrome (odds ratio = 0.92, P = 0.003). Conclusions: Low levels of SHBG in women with PCOS were associated with low levels of HDL-C, independent of insulin resistance and obesity. The SHBG level was inversely related to the occurrence of metabolic syndrome, further strengthening the potential link between SHBG levels and cardiovascular disease in women with PCOS.

KW - Cardiovascular disease

KW - High-density lipoprotein cholesterol

KW - Metabolic syndrome

KW - PCOS

KW - SHBG

UR - http://www.scopus.com/inward/record.url?scp=33749568755&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=33749568755&partnerID=8YFLogxK

U2 - 10.1093/humrep/del175

DO - 10.1093/humrep/del175

M3 - Article

C2 - 16757555

AN - SCOPUS:33749568755

VL - 21

SP - 2266

EP - 2271

JO - Human Reproduction

JF - Human Reproduction

SN - 0268-1161

IS - 9

ER -