Low-dose weekly docetaxel is as tolerable as pemetrexed in previously treated advanced non-small-cell lung cancer

Fu Tsai Chung, Kang Yun Lee, Yueh Fu Fang, Meng Heng Shieh, Shu Min Lin, Chih Teng Yu, Yun Lun Lo, Ting Yu Lin, Chih Hsi Kuo, Po Hao Feng, Yung Lun Ni, Han Pin Kuo

Research output: Contribution to journalArticle

13 Citations (Scopus)

Abstract

Objectives: Docetaxel and pemetrexed have been validated as therapeutics for previously treated advanced non-small-cell lung cancer (NSCLC), but tolerability is a concern for standard treatment with docetaxel administered once every 3 weeks (tri-weekly 75-mg/m2 schedule). We conducted this retrospective study to compare the efficacy and toxicity of weekly low-dose docetaxel versus tri-weekly pemetrexed for previously treated advanced NSCLC. Methods: Consecutive patients who received low-dose single docetaxel (30 mg/m2 on days 1 and 8 every 3 weeks) or pemetrexed (500 mg/m 2 every 3 weeks) at a single university-affiliated hospital following failure of previous treatment were retrospectively reviewed. Their outcomes and toxicity profiles were determined. Results: 179 patients were included between 2005 and 2008 (docetaxel, n = 79; pemetrexed, n = 100). Both groups had similar hematologic (16.5 vs. 15.0%; p = 0.84) and non-hematologic (20.3 vs. 24%; p = 0.55) toxicities. After controlling for confounding factors, docetaxel remained superior to pemetrexed for progression-free survival (median 4.0 vs. 2.4 months; hazard ratio 0.64; 95% CI 0.47-0.87; p = 0.005) and overall survival (median 15.0 vs.8.5 months; hazard ratio 0.54; 95% CI 0.38-0.77; p

Original languageEnglish
Pages (from-to)147-155
Number of pages9
JournalChemotherapy
Volume57
Issue number2
DOIs
Publication statusPublished - Apr 2011
Externally publishedYes

Keywords

  • Advanced non-small-cell lung cancer
  • Docetaxel
  • Pemetrexed

ASJC Scopus subject areas

  • Pharmacology (medical)
  • Oncology
  • Infectious Diseases
  • Pharmacology
  • Drug Discovery

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  • Cite this

    Chung, F. T., Lee, K. Y., Fang, Y. F., Shieh, M. H., Lin, S. M., Yu, C. T., Lo, Y. L., Lin, T. Y., Kuo, C. H., Feng, P. H., Ni, Y. L., & Kuo, H. P. (2011). Low-dose weekly docetaxel is as tolerable as pemetrexed in previously treated advanced non-small-cell lung cancer. Chemotherapy, 57(2), 147-155. https://doi.org/10.1159/000321037