Abstract

Background. Traumatic brain injuries (TBIs) are a major health care problem worldwide. Approximately 1.5 million new TBI cases occur annually in the United States, with mortality rates ranging between 35% and 40% in severe patients. Despite the incidence of these injuries and their substantial socioeconomic implications, no specific pharmacological intervention is available for clinical use. Several studies have indicated that 300 mg/kg or 400 mg/kg of valproate (VPA) exhibits neuroprotective effects in animal models. However, humans cannot tolerate high doses of VPA. This study aims to investigate whether 30 mg/kg of VPA administered to rats affects TBIs. Methods. We used a rat model to test the effects of 30 mg/kg of VPA on TBIs. Molecular identifications for histone acetylation and phosphorylation of cAMP response element-binding protein (CREB) and phosphorylated extracellular signal regulated kinase (ERK) were performed. Results. The results indicated that treating adult rats with VPA after TBIs significantly decreased the contusion volume and recovery of contusion-related skilled forelimb reaching deficits. Applying VPA also increased histone acetylation, p-ERK, and p-CREB expression in the brain. Furthermore, applying VPA reduced inflammation, glial fibrillary acidic protein activation, and apoptosis. Conclusion. This study found that 30 mg/kg of VPA assists in treating TBIs in rat models.

Original languageEnglish
Article number980657
JournalBioMed Research International
Volume2014
DOIs
Publication statusPublished - 2014

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Valproic Acid
Brain
Rats
Acetylation
Cyclic AMP Response Element-Binding Protein
Contusions
Extracellular Signal-Regulated MAP Kinases
Histones
Phosphorylation
Forelimb
Traumatic Brain Injury
Glial Fibrillary Acidic Protein
Neuroprotective Agents
Health care
Animals
Animal Models
Chemical activation
Pharmacology
Apoptosis
Inflammation

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)
  • Immunology and Microbiology(all)
  • Medicine(all)

Cite this

Low dose of valproate improves motor function after traumatic brain injury. / Tai, Yu Ting; Lee, Wen Yuan; Lee, Fei Peng; Lin, Tien Jen; Shih, Chia Lin; Wang, Jia Yi; Chiu, Wen Ta; Hung, Kuo Sheng.

In: BioMed Research International, Vol. 2014, 980657, 2014.

Research output: Contribution to journalArticle

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AU - Tai, Yu Ting

AU - Lee, Wen Yuan

AU - Lee, Fei Peng

AU - Lin, Tien Jen

AU - Shih, Chia Lin

AU - Wang, Jia Yi

AU - Chiu, Wen Ta

AU - Hung, Kuo Sheng

PY - 2014

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