Loss to followup in HIV-infected patients from Asia-pacific region

Results from TAHOD

Jialun Zhou, Junko Tanuma, Romanee Chaiwarith, Christopher K.C. Lee, Matthew G. Law, Nagalingeswaran Kumarasamy, Praphan Phanuphak, Yi Ming A. Chen, Sasisopin Kiertiburanakul, Fujie Zhang, Saphonn Vonthanak, Rossana Ditangco, Sanjay Pujari, Jun Yong Choi, Tuti Parwati Merati, Evy Yunihastuti, Patrick C.K. Li, Adeeba Kamarulzaman, Van Kinh Nguyen, Thi Thanh Thuy Pham & 1 others Poh Lian Lim

Research output: Contribution to journalArticle

21 Citations (Scopus)

Abstract

This study examined characteristics of HIV-infected patients in the TREAT Asia HIV Observational Database who were lost to follow-up (LTFU) from treatment and care. Time from last clinic visit to 31 March 2009 was analysed to determine the interval that best classified LTFU. Patients defined as LTFU were then categorised into permanently LTFU (never returned) and temporary LTFU (re-entered later), and these groups compared. A total of 3626 patients were included (71% male). No clinic visits for 180 days was the best-performing LTFU definition (sensitivity 90.6%, specificity 92.3%). During 7697 person-years of follow-up, 1648 episodes of LFTU were recorded (21.4 per 100-person-years). Patients LFTU were younger (P = 0.002), had HIV viral load ≥500 copies/mL or missing (P = 0.021), had shorter history of HIV infection (P = 0.048), and received no, single- or double-antiretroviral therapy, or a triple-drug regimen containing a protease inhibitor (P < 0.001). 48% of patients LTFU never returned. These patients were more likely to have low or missing haemoglobin (P < 0.001), missing recent HIV viral load (P < 0.001), negative hepatitis C test (P = 0.025), and previous temporary LTFU episodes (P < 0.001). Our analyses suggest that patients not seen at a clinic for 180 days are at high risk of permanent LTFU, and should be aggressively traced.

Original languageEnglish
Article number375217
JournalAIDS Research and Treatment
Volume2012
DOIs
Publication statusPublished - Dec 1 2012
Externally publishedYes

Fingerprint

Lost to Follow-Up
HIV
Ambulatory Care
Viral Load
Aftercare
Hepatitis C
Protease Inhibitors
HIV Infections
Databases
Sensitivity and Specificity
Therapeutics

ASJC Scopus subject areas

  • Immunology and Allergy
  • Dermatology
  • Public Health, Environmental and Occupational Health
  • Infectious Diseases

Cite this

Zhou, J., Tanuma, J., Chaiwarith, R., Lee, C. K. C., Law, M. G., Kumarasamy, N., ... Lim, P. L. (2012). Loss to followup in HIV-infected patients from Asia-pacific region: Results from TAHOD. AIDS Research and Treatment, 2012, [375217]. https://doi.org/10.1155/2012/375217

Loss to followup in HIV-infected patients from Asia-pacific region : Results from TAHOD. / Zhou, Jialun; Tanuma, Junko; Chaiwarith, Romanee; Lee, Christopher K.C.; Law, Matthew G.; Kumarasamy, Nagalingeswaran; Phanuphak, Praphan; Chen, Yi Ming A.; Kiertiburanakul, Sasisopin; Zhang, Fujie; Vonthanak, Saphonn; Ditangco, Rossana; Pujari, Sanjay; Choi, Jun Yong; Parwati Merati, Tuti; Yunihastuti, Evy; Li, Patrick C.K.; Kamarulzaman, Adeeba; Nguyen, Van Kinh; Thuy Pham, Thi Thanh; Lim, Poh Lian.

In: AIDS Research and Treatment, Vol. 2012, 375217, 01.12.2012.

Research output: Contribution to journalArticle

Zhou, J, Tanuma, J, Chaiwarith, R, Lee, CKC, Law, MG, Kumarasamy, N, Phanuphak, P, Chen, YMA, Kiertiburanakul, S, Zhang, F, Vonthanak, S, Ditangco, R, Pujari, S, Choi, JY, Parwati Merati, T, Yunihastuti, E, Li, PCK, Kamarulzaman, A, Nguyen, VK, Thuy Pham, TT & Lim, PL 2012, 'Loss to followup in HIV-infected patients from Asia-pacific region: Results from TAHOD', AIDS Research and Treatment, vol. 2012, 375217. https://doi.org/10.1155/2012/375217
Zhou, Jialun ; Tanuma, Junko ; Chaiwarith, Romanee ; Lee, Christopher K.C. ; Law, Matthew G. ; Kumarasamy, Nagalingeswaran ; Phanuphak, Praphan ; Chen, Yi Ming A. ; Kiertiburanakul, Sasisopin ; Zhang, Fujie ; Vonthanak, Saphonn ; Ditangco, Rossana ; Pujari, Sanjay ; Choi, Jun Yong ; Parwati Merati, Tuti ; Yunihastuti, Evy ; Li, Patrick C.K. ; Kamarulzaman, Adeeba ; Nguyen, Van Kinh ; Thuy Pham, Thi Thanh ; Lim, Poh Lian. / Loss to followup in HIV-infected patients from Asia-pacific region : Results from TAHOD. In: AIDS Research and Treatment. 2012 ; Vol. 2012.
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AU - Lee, Christopher K.C.

AU - Law, Matthew G.

AU - Kumarasamy, Nagalingeswaran

AU - Phanuphak, Praphan

AU - Chen, Yi Ming A.

AU - Kiertiburanakul, Sasisopin

AU - Zhang, Fujie

AU - Vonthanak, Saphonn

AU - Ditangco, Rossana

AU - Pujari, Sanjay

AU - Choi, Jun Yong

AU - Parwati Merati, Tuti

AU - Yunihastuti, Evy

AU - Li, Patrick C.K.

AU - Kamarulzaman, Adeeba

AU - Nguyen, Van Kinh

AU - Thuy Pham, Thi Thanh

AU - Lim, Poh Lian

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N2 - This study examined characteristics of HIV-infected patients in the TREAT Asia HIV Observational Database who were lost to follow-up (LTFU) from treatment and care. Time from last clinic visit to 31 March 2009 was analysed to determine the interval that best classified LTFU. Patients defined as LTFU were then categorised into permanently LTFU (never returned) and temporary LTFU (re-entered later), and these groups compared. A total of 3626 patients were included (71% male). No clinic visits for 180 days was the best-performing LTFU definition (sensitivity 90.6%, specificity 92.3%). During 7697 person-years of follow-up, 1648 episodes of LFTU were recorded (21.4 per 100-person-years). Patients LFTU were younger (P = 0.002), had HIV viral load ≥500 copies/mL or missing (P = 0.021), had shorter history of HIV infection (P = 0.048), and received no, single- or double-antiretroviral therapy, or a triple-drug regimen containing a protease inhibitor (P < 0.001). 48% of patients LTFU never returned. These patients were more likely to have low or missing haemoglobin (P < 0.001), missing recent HIV viral load (P < 0.001), negative hepatitis C test (P = 0.025), and previous temporary LTFU episodes (P < 0.001). Our analyses suggest that patients not seen at a clinic for 180 days are at high risk of permanent LTFU, and should be aggressively traced.

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