Loss of terminal deoxynucleotidyl transferase (TDT) activity as a predictor of emergence of resistance to chemotherapy in a case of chronic myelogenous leukemia in blast crisis

Douglas D. Ross, Peter H. Wiernik, Prem S. Sarin, Jacqueline Whang‐Peng

Research output: Contribution to journalArticle

12 Citations (Scopus)

Abstract

A 46‐year‐old female with chronic myelogenous leukemia (CML) in blast crisis was monitored for terminal deoxynucleotidyltransferase (TdT) activity of marrow and peripheral blood throughout the course of her illness. TdT was elevated at the time of diagnosis of blastic transformation, and the patient easily obtained remission after therapy with hydroxyurea, 6‐mercaptopurine and prednisone. The patient enjoyed a remission of eight months duration, and at time of relapse, marrow TdT was again elevated. The patient again obtained complete remission with the same regimen, with the addition of vincristine, given weekly. This second remission was shortlived, however, and at relapse marrow TdT activity was undetectable. Subsequently, the patient failed to achieve remission, despite the use of a wide variety of chemotherapeutic agents. This case suggests that loss of TdT activity in blastic CML cells marks the emergence of cells resistant to existing chemotherapeutic agents.

Original languageEnglish
Pages (from-to)1566-1570
Number of pages5
JournalCancer
Volume44
Issue number5
DOIs
Publication statusPublished - Jan 1 1979
Externally publishedYes

Fingerprint

Blast Crisis
DNA Nucleotidylexotransferase
Leukemia, Myelogenous, Chronic, BCR-ABL Positive
Drug Therapy
Bone Marrow
Recurrence
Hydroxyurea
Vincristine
Prednisone

ASJC Scopus subject areas

  • Oncology
  • Cancer Research

Cite this

Loss of terminal deoxynucleotidyl transferase (TDT) activity as a predictor of emergence of resistance to chemotherapy in a case of chronic myelogenous leukemia in blast crisis. / Ross, Douglas D.; Wiernik, Peter H.; Sarin, Prem S.; Whang‐Peng, Jacqueline.

In: Cancer, Vol. 44, No. 5, 01.01.1979, p. 1566-1570.

Research output: Contribution to journalArticle

@article{f80aa9ee6bec4dd2a392003fc2644e12,
title = "Loss of terminal deoxynucleotidyl transferase (TDT) activity as a predictor of emergence of resistance to chemotherapy in a case of chronic myelogenous leukemia in blast crisis",
abstract = "A 46‐year‐old female with chronic myelogenous leukemia (CML) in blast crisis was monitored for terminal deoxynucleotidyltransferase (TdT) activity of marrow and peripheral blood throughout the course of her illness. TdT was elevated at the time of diagnosis of blastic transformation, and the patient easily obtained remission after therapy with hydroxyurea, 6‐mercaptopurine and prednisone. The patient enjoyed a remission of eight months duration, and at time of relapse, marrow TdT was again elevated. The patient again obtained complete remission with the same regimen, with the addition of vincristine, given weekly. This second remission was shortlived, however, and at relapse marrow TdT activity was undetectable. Subsequently, the patient failed to achieve remission, despite the use of a wide variety of chemotherapeutic agents. This case suggests that loss of TdT activity in blastic CML cells marks the emergence of cells resistant to existing chemotherapeutic agents.",
author = "Ross, {Douglas D.} and Wiernik, {Peter H.} and Sarin, {Prem S.} and Jacqueline Whang‐Peng",
year = "1979",
month = "1",
day = "1",
doi = "10.1002/1097-0142(197911)44:5<1566::AID-CNCR2820440504>3.0.CO;2-G",
language = "English",
volume = "44",
pages = "1566--1570",
journal = "Cancer",
issn = "0008-543X",
publisher = "John Wiley and Sons Inc.",
number = "5",

}

TY - JOUR

T1 - Loss of terminal deoxynucleotidyl transferase (TDT) activity as a predictor of emergence of resistance to chemotherapy in a case of chronic myelogenous leukemia in blast crisis

AU - Ross, Douglas D.

AU - Wiernik, Peter H.

AU - Sarin, Prem S.

AU - Whang‐Peng, Jacqueline

PY - 1979/1/1

Y1 - 1979/1/1

N2 - A 46‐year‐old female with chronic myelogenous leukemia (CML) in blast crisis was monitored for terminal deoxynucleotidyltransferase (TdT) activity of marrow and peripheral blood throughout the course of her illness. TdT was elevated at the time of diagnosis of blastic transformation, and the patient easily obtained remission after therapy with hydroxyurea, 6‐mercaptopurine and prednisone. The patient enjoyed a remission of eight months duration, and at time of relapse, marrow TdT was again elevated. The patient again obtained complete remission with the same regimen, with the addition of vincristine, given weekly. This second remission was shortlived, however, and at relapse marrow TdT activity was undetectable. Subsequently, the patient failed to achieve remission, despite the use of a wide variety of chemotherapeutic agents. This case suggests that loss of TdT activity in blastic CML cells marks the emergence of cells resistant to existing chemotherapeutic agents.

AB - A 46‐year‐old female with chronic myelogenous leukemia (CML) in blast crisis was monitored for terminal deoxynucleotidyltransferase (TdT) activity of marrow and peripheral blood throughout the course of her illness. TdT was elevated at the time of diagnosis of blastic transformation, and the patient easily obtained remission after therapy with hydroxyurea, 6‐mercaptopurine and prednisone. The patient enjoyed a remission of eight months duration, and at time of relapse, marrow TdT was again elevated. The patient again obtained complete remission with the same regimen, with the addition of vincristine, given weekly. This second remission was shortlived, however, and at relapse marrow TdT activity was undetectable. Subsequently, the patient failed to achieve remission, despite the use of a wide variety of chemotherapeutic agents. This case suggests that loss of TdT activity in blastic CML cells marks the emergence of cells resistant to existing chemotherapeutic agents.

UR - http://www.scopus.com/inward/record.url?scp=0018616595&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0018616595&partnerID=8YFLogxK

U2 - 10.1002/1097-0142(197911)44:5<1566::AID-CNCR2820440504>3.0.CO;2-G

DO - 10.1002/1097-0142(197911)44:5<1566::AID-CNCR2820440504>3.0.CO;2-G

M3 - Article

C2 - 291471

AN - SCOPUS:0018616595

VL - 44

SP - 1566

EP - 1570

JO - Cancer

JF - Cancer

SN - 0008-543X

IS - 5

ER -