Loss of let-7 microRNA upregulates IL-6 in bone marrow-derived mesenchymal stem cells triggering a reactive stromal response to prostate cancer.

Agriculture & Biology

• prostatic neoplasms 80%
• mesenchymal stromal cells 77%
• interleukin-6 65%
• bone marrow 63%
• microRNA 59%
• neoplasms 34%
• adipogenesis 18%
• neoplasm progression 13%
• neoplasm cells 12%
• metastasis 11%
• luciferase 5%
• transfection 4%
• coculture 4%
• cell movement 4%
• carcinogenesis 4%
• 3' untranslated regions 4%
• laboratory animals 4%
• animal models 3%
• chemical derivatives 3%
• cell lines 3%
• secretion 3%
• phenotype 2%
• genes 1%

Medicine & Life Sciences

• Mesenchymal Stem Cells 52%
• MicroRNAs 49%
• Prostatic Neoplasms 46%
• Interleukin-6 45%
• Up-Regulation 42%
• Neoplasms 13%
• Adipogenesis 10%
• Tumor Microenvironment 9%
• Down-Regulation 6%
• Neoplasm Metastasis 5%
• 3' Untranslated Regions 4%
• Coculture Techniques 4%
• Luciferases 4%
• In Vitro Techniques 3%
• Transfection 3%
• Cell Movement 3%
• Carcinogenesis 3%
• Animal Models 3%
• Phenotype 2%
• Cell Line 2%
• Genes 1%

Chemical Compounds

• Adipogenic 100%
• MicroRNA 72%