Loss of epithelial membrane protein-2 expression confers an independent prognosticator in gallbladder carcinoma

Chien Feng Li, Li Tzong Chen, Ching Yih Lin, Yu Hui Wang, Hsuan Ying Huang, Chung Hsi Hsing, Chia Jung Tsai, Yow Ling Shiue

Research output: Contribution to journalArticle

Abstract

The objective of this study was to evaluate the expression of epithelial membrane protein-2 (EMP2) and its clinicopathological associations in patients with gallbladder carcinoma (GBC). A retrospective population-based cohort study was performed based on a biobank from 1986 to 2005. Biopsies of 164 GBC patients without initial distant metastasis were collected during surgical intervention. Immunoexpressions of EMP2 and Ki-67 were analyzed and the outcomes were correlated with clinicopathological features and patient survival. Results indicated that loss of EMP2 expression (50%) was correlated with female patients ( p=0.037), advanced primary tumor ( p

Original languageEnglish
Pages (from-to)31-38
Number of pages8
JournalBiomarkers and Genomic Medicine
Volume5
Issue number1-2
DOIs
Publication statusPublished - 2013
Externally publishedYes

Keywords

  • Epithelial membrane protein-2
  • Gallbladder carcinoma
  • Survival

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)
  • Biomedical Engineering
  • Medicine(all)
  • Drug Discovery

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  • Cite this

    Li, C. F., Chen, L. T., Lin, C. Y., Wang, Y. H., Huang, H. Y., Hsing, C. H., Tsai, C. J., & Shiue, Y. L. (2013). Loss of epithelial membrane protein-2 expression confers an independent prognosticator in gallbladder carcinoma. Biomarkers and Genomic Medicine, 5(1-2), 31-38. https://doi.org/10.1016/j.gmbhs.2013.04.004