Lorazepam modulates orbitofrontal signal changes during emotional processing in catatonia

Andre Richter, Simone Grimm, Georg Northoff

Research output: Contribution to journalArticle

28 Citations (Scopus)

Abstract

Objective: Catatonia is a psychomotor syndrome characterized by concomitant emotional, behavioural and motor symptoms. In many cases clinical symptoms disappear almost immediately with administration of lorazepam, which acts on GABAA receptors. Methods: Using functional magnetic resonance imaging (fMRI) we investigated prefrontal activation patterns during emotion processing in catatonic patients with and without lorazepam in a double-blind study design. For emotional stimulation the International Affective Picture System (IAPS) was used. BOLD-signals were determined using regions of interest (ROI) and were statistically compared between groups. Results: For negative emotional pictures lorazepam induced higher signal decreases in the orbitofrontal cortex (OFC) in catatonic patients than in healthy subjects resulting in a regularization of activity patterns comparable to healthy subjects with placebo. Conclusions: Results indicate disturbances in the functioning of OFC in catatonia. GABAergic modified emotion regulation with decreased inhibition of affective stimuli could lead to the intense emotions reported by many catatonic patients.

Original languageEnglish
Pages (from-to)55-62
Number of pages8
JournalHuman Psychopharmacology
Volume25
Issue number1
DOIs
Publication statusPublished - 2010
Externally publishedYes

Fingerprint

Catatonia
Lorazepam
Emotions
Prefrontal Cortex
Healthy Volunteers
Behavioral Symptoms
GABA-A Receptors
Double-Blind Method
Placebos
Magnetic Resonance Imaging

Keywords

  • Affect
  • Benzodiazepine
  • Catatonia
  • Fmri

ASJC Scopus subject areas

  • Clinical Neurology
  • Psychiatry and Mental health
  • Neurology
  • Pharmacology (medical)

Cite this

Lorazepam modulates orbitofrontal signal changes during emotional processing in catatonia. / Richter, Andre; Grimm, Simone; Northoff, Georg.

In: Human Psychopharmacology, Vol. 25, No. 1, 2010, p. 55-62.

Research output: Contribution to journalArticle

@article{5cfec6c2feab4a93bd7c6876a04e2274,
title = "Lorazepam modulates orbitofrontal signal changes during emotional processing in catatonia",
abstract = "Objective: Catatonia is a psychomotor syndrome characterized by concomitant emotional, behavioural and motor symptoms. In many cases clinical symptoms disappear almost immediately with administration of lorazepam, which acts on GABAA receptors. Methods: Using functional magnetic resonance imaging (fMRI) we investigated prefrontal activation patterns during emotion processing in catatonic patients with and without lorazepam in a double-blind study design. For emotional stimulation the International Affective Picture System (IAPS) was used. BOLD-signals were determined using regions of interest (ROI) and were statistically compared between groups. Results: For negative emotional pictures lorazepam induced higher signal decreases in the orbitofrontal cortex (OFC) in catatonic patients than in healthy subjects resulting in a regularization of activity patterns comparable to healthy subjects with placebo. Conclusions: Results indicate disturbances in the functioning of OFC in catatonia. GABAergic modified emotion regulation with decreased inhibition of affective stimuli could lead to the intense emotions reported by many catatonic patients.",
keywords = "Affect, Benzodiazepine, Catatonia, Fmri",
author = "Andre Richter and Simone Grimm and Georg Northoff",
year = "2010",
doi = "10.1002/hup.1084",
language = "English",
volume = "25",
pages = "55--62",
journal = "Human Psychopharmacology",
issn = "0885-6222",
publisher = "John Wiley and Sons Ltd",
number = "1",

}

TY - JOUR

T1 - Lorazepam modulates orbitofrontal signal changes during emotional processing in catatonia

AU - Richter, Andre

AU - Grimm, Simone

AU - Northoff, Georg

PY - 2010

Y1 - 2010

N2 - Objective: Catatonia is a psychomotor syndrome characterized by concomitant emotional, behavioural and motor symptoms. In many cases clinical symptoms disappear almost immediately with administration of lorazepam, which acts on GABAA receptors. Methods: Using functional magnetic resonance imaging (fMRI) we investigated prefrontal activation patterns during emotion processing in catatonic patients with and without lorazepam in a double-blind study design. For emotional stimulation the International Affective Picture System (IAPS) was used. BOLD-signals were determined using regions of interest (ROI) and were statistically compared between groups. Results: For negative emotional pictures lorazepam induced higher signal decreases in the orbitofrontal cortex (OFC) in catatonic patients than in healthy subjects resulting in a regularization of activity patterns comparable to healthy subjects with placebo. Conclusions: Results indicate disturbances in the functioning of OFC in catatonia. GABAergic modified emotion regulation with decreased inhibition of affective stimuli could lead to the intense emotions reported by many catatonic patients.

AB - Objective: Catatonia is a psychomotor syndrome characterized by concomitant emotional, behavioural and motor symptoms. In many cases clinical symptoms disappear almost immediately with administration of lorazepam, which acts on GABAA receptors. Methods: Using functional magnetic resonance imaging (fMRI) we investigated prefrontal activation patterns during emotion processing in catatonic patients with and without lorazepam in a double-blind study design. For emotional stimulation the International Affective Picture System (IAPS) was used. BOLD-signals were determined using regions of interest (ROI) and were statistically compared between groups. Results: For negative emotional pictures lorazepam induced higher signal decreases in the orbitofrontal cortex (OFC) in catatonic patients than in healthy subjects resulting in a regularization of activity patterns comparable to healthy subjects with placebo. Conclusions: Results indicate disturbances in the functioning of OFC in catatonia. GABAergic modified emotion regulation with decreased inhibition of affective stimuli could lead to the intense emotions reported by many catatonic patients.

KW - Affect

KW - Benzodiazepine

KW - Catatonia

KW - Fmri

UR - http://www.scopus.com/inward/record.url?scp=76149092852&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=76149092852&partnerID=8YFLogxK

U2 - 10.1002/hup.1084

DO - 10.1002/hup.1084

M3 - Article

C2 - 20041475

AN - SCOPUS:76149092852

VL - 25

SP - 55

EP - 62

JO - Human Psychopharmacology

JF - Human Psychopharmacology

SN - 0885-6222

IS - 1

ER -