Longitudinal MR imaging study in the prediction of ischemic susceptibility after cerebral hypoperfusion in rats

Influence of aging and hypertension

J. T. Lee, H. L. Liu, J. T. Yang, S. T. Yang, J. R. Lin, T. H. Lee

Research output: Contribution to journalArticle

6 Citations (Scopus)

Abstract

Our previous study has shown that aging and hypertension may alter apparent diffusion coefficient (ADC) and cerebral blood flow (CBF) and increase ischemic susceptibility in the non-ischemic rat brain. The present study wishes to further investigate whether aging and hypertension may influence cerebral diffusion/perfusion and increase ischemic susceptibility in the ischemic brain. Brain magnetic resonance (MR) imaging was examined 1. day before and 1 and 7. days after bilateral common carotid artery occlusion. Young and middle-aged normotensive Wistar-Kyoto rats and young and middle-aged spontaneously hypertensive rats (SHRs) were studied. Infarction occurred mainly in the parietal cortex and was larger in middle-aged SHRs than the other three groups (P

Original languageEnglish
Pages (from-to)31-40
Number of pages10
JournalNeuroscience
Volume257
DOIs
Publication statusPublished - Jan 17 2014

Fingerprint

Magnetic Resonance Imaging
Inbred SHR Rats
Hypertension
Cerebrovascular Circulation
Brain
Parietal Lobe
Inbred WKY Rats
Common Carotid Artery
Infarction
Perfusion

Keywords

  • Aging
  • Carotid artery
  • Cerebral hypoperfusion
  • Diffusion-weighted MRI
  • Hypertension
  • Perfusion-weighted MRI

ASJC Scopus subject areas

  • Neuroscience(all)

Cite this

Longitudinal MR imaging study in the prediction of ischemic susceptibility after cerebral hypoperfusion in rats : Influence of aging and hypertension. / Lee, J. T.; Liu, H. L.; Yang, J. T.; Yang, S. T.; Lin, J. R.; Lee, T. H.

In: Neuroscience, Vol. 257, 17.01.2014, p. 31-40.

Research output: Contribution to journalArticle

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