Longitudinal MR imaging study in the prediction of ischemic susceptibility after cerebral hypoperfusion in rats: Influence of aging and hypertension

J. T. Lee, H. L. Liu, J. T. Yang, S. T. Yang, J. R. Lin, T. H. Lee

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6 Citations (Scopus)

Abstract

Our previous study has shown that aging and hypertension may alter apparent diffusion coefficient (ADC) and cerebral blood flow (CBF) and increase ischemic susceptibility in the non-ischemic rat brain. The present study wishes to further investigate whether aging and hypertension may influence cerebral diffusion/perfusion and increase ischemic susceptibility in the ischemic brain. Brain magnetic resonance (MR) imaging was examined 1. day before and 1 and 7. days after bilateral common carotid artery occlusion. Young and middle-aged normotensive Wistar-Kyoto rats and young and middle-aged spontaneously hypertensive rats (SHRs) were studied. Infarction occurred mainly in the parietal cortex and was larger in middle-aged SHRs than the other three groups (P

Original languageEnglish
Pages (from-to)31-40
Number of pages10
JournalNeuroscience
Volume257
DOIs
Publication statusPublished - Jan 17 2014

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Keywords

  • Aging
  • Carotid artery
  • Cerebral hypoperfusion
  • Diffusion-weighted MRI
  • Hypertension
  • Perfusion-weighted MRI

ASJC Scopus subject areas

  • Neuroscience(all)

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