Longitudinal changes in physical and mental health of older adults with chronic hepatitis B infection: Trajectories and predictors

Chang Hua Chen, Ming Shiang Wu, Yu Wen Yang, Yen Tze Liu, Yen Feng Chiu, Chih Cheng Hsu, Shu Chun Chuang, Tieh Chi Chung, Tsung Lung Tsai, Wen Hao Huang, Wei Lin Huang, Chung Chou Juan, Li Ming Lien, Chao A. Hsiung, I. Chien Wu

Research output: Contribution to journalArticlepeer-review


Despite the increasing health burden of chronic hepatitis B (CHB) in aging populations, little is known about the course of health-related quality of life (HRQoL) changes. We aimed to assess individual-level longitudinal HRQoL changes in elderly patients with CHB and to examine their correlates. A prospective 5.1 years-cohort study was conducted in community-dwelling adults aged 55 years with hepatitis B surface antigen-positive. Participants underwent serial measurement of HRQoL using the short-form (12) health survey version 2. Of 503 participants, 82.7% remained in good physical health throughout the study period, whereas 9.1% had declining physical health and 8.2% were in poor physical health. We likewise identified three trajectories of mental health changes (“good mental health” [86.9%], “declining mental health” [6.8%], and “poor mental health” [6.4%]). Three baseline characteristics were independently associated with a lower likelihood of remaining physically or mentally healthy: sarcopenic obesity (odds ratio [OR] with 95% confidence interval [95% CI] of 7.5 [2.8–20.5] for poor physical health, 3.1 [1.1–8.4] for declining physical health, 4.3 [1.4–13.0] for poor mental health), a higher number of metabolic abnormalities (OR [95% CI] of 3.6 [1.6–8.0] for poor physical health) and depressed mood (OR [95% CI] of 21.7 [5.8–81.0] for poor physical health, 5.3 [1.4–19.9] for declining physical health, 83.1 [19.7–350.2] for poor mental health, 13.6 [2.9–64.8] for declining mental health). In conclusion, in a cohort of elderly patients with CHB, we demonstrated the heterogeneity and nonlinearity of HRQoL changes and their associations with variations in specific extrahepatic organs/systems.

Original languageEnglish
Article number101432
JournalPreventive Medicine Reports
Publication statusPublished - Sept 2021


  • Aging
  • Geriatric assessment
  • Group-based trajectory modeling
  • Health-related quality of life
  • Healthy Aging Longitudinal Study in Taiwan (HALST)

ASJC Scopus subject areas

  • Health Informatics
  • Public Health, Environmental and Occupational Health


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