Longevity and lifespan control in mammals: Lessons from the mouse

Yi Fan Chen, Chia Yu Wu, Cheng Heng Kao, Ting Fen Tsai

Research output: Contribution to journalReview article

33 Citations (Scopus)

Abstract

Aging, which affects all organ systems, is one of the most complex phenotypes. Recent discoveries in long-lived mutant mice have revealed molecular mechanisms of longevity in mammals which may contribute to our understanding of why humans age. These mutations include naturally occurring spontaneous mutations, and those of mice genetically modified by modern genomic technologies. It is generally believed that the most fundamental mechanisms of aging are evolutionarily conserved across species. The following types of longevity mechanisms have been intensively studied: suppression of the somatotropic (growth hormone/insulin-like growth factor 1) axis, decreased metabolism and increased resistance of oxidative stress, reduced insulin secretion and increased insulin sensitivity, and delayed reproductive maturation and reduced fertility. In addition, many of the mutations have a sex-dependent effect on lifespan, and when present in different genetic backgrounds, the effects of the same gene mutation can vary considerably. The present review discusses these phenotypic variations as well as describing the known longevity genes in long-lived mutant mice and the molecular mechanisms specifying longevity. We anticipate that these mouse studies will ultimately provide clues about how to delay the aging and prolong lifespan, and help to develop therapies for healthier human aging.

Original languageEnglish
JournalAgeing Research Reviews
Volume9
Issue numberSUPPL.
DOIs
Publication statusPublished - Nov 2010
Externally publishedYes

Fingerprint

Mammals
Aging of materials
Mutation
Genes
Insulin
Oxidative stress
Somatomedins
Metabolism
Growth Hormone
Fertility
Insulin Resistance
Oxidative Stress
Technology
Phenotype
Therapeutics

Keywords

  • Aging
  • Lifespan
  • Long-lived mice
  • Longevity

ASJC Scopus subject areas

  • Ageing
  • Biochemistry
  • Biotechnology
  • Molecular Biology
  • Neurology

Cite this

Longevity and lifespan control in mammals : Lessons from the mouse. / Chen, Yi Fan; Wu, Chia Yu; Kao, Cheng Heng; Tsai, Ting Fen.

In: Ageing Research Reviews, Vol. 9, No. SUPPL., 11.2010.

Research output: Contribution to journalReview article

Chen, Yi Fan ; Wu, Chia Yu ; Kao, Cheng Heng ; Tsai, Ting Fen. / Longevity and lifespan control in mammals : Lessons from the mouse. In: Ageing Research Reviews. 2010 ; Vol. 9, No. SUPPL.
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