Longer duration and earlier age of onset of paternal betel chewing and smoking increase metabolic syndrome risk in human offspring, independently, in a community-based screening program in Taiwan

Amy Ming Fang Yen, Barbara J. Boucher, Sherry Yueh Hsia Chiu, Jean Ching Yuan Fann, Sam Li Sheng Chen, Kuo Chin Huang, Hsiu His Chen

Research output: Contribution to journalArticle

9 Citations (Scopus)

Abstract

Background: Transgenerational effects of paternal Areca catechu nut chewing on offspring metabolic syndrome (MetS) risk in humans, on obesity and diabetes mellitus experimentally, and of paternal smoking on offspring obesity, are reported, likely attributable to genetic and epigenetic effects previously reported in betel-associated disease. We aimed to determine the effects of paternal smoking, and betel chewing, on the risks of early MetS in human offspring. Methods: The 13 179 parent-child trios identified from 238 364 Taiwanese aged ≥20 years screened at 2 community-based integrated screening sessions were tested for the effects of paternal smoking, areca nut chewing, and their duration prefatherhood on age of detecting offspring MetS at screen by using a Cox proportional hazards regression model. Results: Offspring MetS risks increased with prefatherhood paternal areca nutusage (adjusted hazard ratio, 1.77; 95% confidence interval [CI], 1.23-2.53) versus nonchewing fathers (adjusted hazard ratio, 3.28; 95% CI, 1.67-6.43) with >10 years paternal betel chewing, 1.62 (95% CI, 0.88-2.96) for 5 to 9 years, and 1.42 (95% CI, 0.80-2.54) for <5 years betel usage prefatherhood (P trend =0.0002), with increased risk (adjusted hazard ratio, 1.95; 95% CI, 1.26-3.04) for paternal areca nut usage from 20 to 29 years of age, versus from >30 years of age (adjusted hazard ratio,1.61; 95% CI, 0.22-11.69). MetS offspring risk for paternal smoking increased dosewise (P trend <0.0001) with earlier age of onset (P trend =0.0009), independently. Conclusions: Longer duration of paternal betel quid chewing and smoking, prefatherhood, independently predicted early occurrence of incident MetS in offspring, corroborating previously reported transgenerational effects of these habits, and supporting the need for habit-cessation program provision.

Original languageEnglish
Pages (from-to)392-404
Number of pages13
JournalCirculation
Volume134
Issue number5
DOIs
Publication statusPublished - Aug 2 2016

Fingerprint

Mastication
Taiwan
Age of Onset
Smoking
Areca
Confidence Intervals
Nuts
Habits
Obesity
Proportional Hazards Models
Epigenomics
Fathers
Diabetes Mellitus

Keywords

  • areca
  • betel quid
  • cohort effect
  • lime-piper
  • metabolic syndrome X
  • parents
  • smoking

ASJC Scopus subject areas

  • Medicine(all)
  • Cardiology and Cardiovascular Medicine
  • Physiology (medical)

Cite this

Longer duration and earlier age of onset of paternal betel chewing and smoking increase metabolic syndrome risk in human offspring, independently, in a community-based screening program in Taiwan. / Yen, Amy Ming Fang; Boucher, Barbara J.; Chiu, Sherry Yueh Hsia; Fann, Jean Ching Yuan; Chen, Sam Li Sheng; Huang, Kuo Chin; Chen, Hsiu His.

In: Circulation, Vol. 134, No. 5, 02.08.2016, p. 392-404.

Research output: Contribution to journalArticle

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title = "Longer duration and earlier age of onset of paternal betel chewing and smoking increase metabolic syndrome risk in human offspring, independently, in a community-based screening program in Taiwan",
abstract = "Background: Transgenerational effects of paternal Areca catechu nut chewing on offspring metabolic syndrome (MetS) risk in humans, on obesity and diabetes mellitus experimentally, and of paternal smoking on offspring obesity, are reported, likely attributable to genetic and epigenetic effects previously reported in betel-associated disease. We aimed to determine the effects of paternal smoking, and betel chewing, on the risks of early MetS in human offspring. Methods: The 13 179 parent-child trios identified from 238 364 Taiwanese aged ≥20 years screened at 2 community-based integrated screening sessions were tested for the effects of paternal smoking, areca nut chewing, and their duration prefatherhood on age of detecting offspring MetS at screen by using a Cox proportional hazards regression model. Results: Offspring MetS risks increased with prefatherhood paternal areca nutusage (adjusted hazard ratio, 1.77; 95{\%} confidence interval [CI], 1.23-2.53) versus nonchewing fathers (adjusted hazard ratio, 3.28; 95{\%} CI, 1.67-6.43) with >10 years paternal betel chewing, 1.62 (95{\%} CI, 0.88-2.96) for 5 to 9 years, and 1.42 (95{\%} CI, 0.80-2.54) for <5 years betel usage prefatherhood (P trend =0.0002), with increased risk (adjusted hazard ratio, 1.95; 95{\%} CI, 1.26-3.04) for paternal areca nut usage from 20 to 29 years of age, versus from >30 years of age (adjusted hazard ratio,1.61; 95{\%} CI, 0.22-11.69). MetS offspring risk for paternal smoking increased dosewise (P trend <0.0001) with earlier age of onset (P trend =0.0009), independently. Conclusions: Longer duration of paternal betel quid chewing and smoking, prefatherhood, independently predicted early occurrence of incident MetS in offspring, corroborating previously reported transgenerational effects of these habits, and supporting the need for habit-cessation program provision.",
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author = "Yen, {Amy Ming Fang} and Boucher, {Barbara J.} and Chiu, {Sherry Yueh Hsia} and Fann, {Jean Ching Yuan} and Chen, {Sam Li Sheng} and Huang, {Kuo Chin} and Chen, {Hsiu His}",
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T1 - Longer duration and earlier age of onset of paternal betel chewing and smoking increase metabolic syndrome risk in human offspring, independently, in a community-based screening program in Taiwan

AU - Yen, Amy Ming Fang

AU - Boucher, Barbara J.

AU - Chiu, Sherry Yueh Hsia

AU - Fann, Jean Ching Yuan

AU - Chen, Sam Li Sheng

AU - Huang, Kuo Chin

AU - Chen, Hsiu His

PY - 2016/8/2

Y1 - 2016/8/2

N2 - Background: Transgenerational effects of paternal Areca catechu nut chewing on offspring metabolic syndrome (MetS) risk in humans, on obesity and diabetes mellitus experimentally, and of paternal smoking on offspring obesity, are reported, likely attributable to genetic and epigenetic effects previously reported in betel-associated disease. We aimed to determine the effects of paternal smoking, and betel chewing, on the risks of early MetS in human offspring. Methods: The 13 179 parent-child trios identified from 238 364 Taiwanese aged ≥20 years screened at 2 community-based integrated screening sessions were tested for the effects of paternal smoking, areca nut chewing, and their duration prefatherhood on age of detecting offspring MetS at screen by using a Cox proportional hazards regression model. Results: Offspring MetS risks increased with prefatherhood paternal areca nutusage (adjusted hazard ratio, 1.77; 95% confidence interval [CI], 1.23-2.53) versus nonchewing fathers (adjusted hazard ratio, 3.28; 95% CI, 1.67-6.43) with >10 years paternal betel chewing, 1.62 (95% CI, 0.88-2.96) for 5 to 9 years, and 1.42 (95% CI, 0.80-2.54) for <5 years betel usage prefatherhood (P trend =0.0002), with increased risk (adjusted hazard ratio, 1.95; 95% CI, 1.26-3.04) for paternal areca nut usage from 20 to 29 years of age, versus from >30 years of age (adjusted hazard ratio,1.61; 95% CI, 0.22-11.69). MetS offspring risk for paternal smoking increased dosewise (P trend <0.0001) with earlier age of onset (P trend =0.0009), independently. Conclusions: Longer duration of paternal betel quid chewing and smoking, prefatherhood, independently predicted early occurrence of incident MetS in offspring, corroborating previously reported transgenerational effects of these habits, and supporting the need for habit-cessation program provision.

AB - Background: Transgenerational effects of paternal Areca catechu nut chewing on offspring metabolic syndrome (MetS) risk in humans, on obesity and diabetes mellitus experimentally, and of paternal smoking on offspring obesity, are reported, likely attributable to genetic and epigenetic effects previously reported in betel-associated disease. We aimed to determine the effects of paternal smoking, and betel chewing, on the risks of early MetS in human offspring. Methods: The 13 179 parent-child trios identified from 238 364 Taiwanese aged ≥20 years screened at 2 community-based integrated screening sessions were tested for the effects of paternal smoking, areca nut chewing, and their duration prefatherhood on age of detecting offspring MetS at screen by using a Cox proportional hazards regression model. Results: Offspring MetS risks increased with prefatherhood paternal areca nutusage (adjusted hazard ratio, 1.77; 95% confidence interval [CI], 1.23-2.53) versus nonchewing fathers (adjusted hazard ratio, 3.28; 95% CI, 1.67-6.43) with >10 years paternal betel chewing, 1.62 (95% CI, 0.88-2.96) for 5 to 9 years, and 1.42 (95% CI, 0.80-2.54) for <5 years betel usage prefatherhood (P trend =0.0002), with increased risk (adjusted hazard ratio, 1.95; 95% CI, 1.26-3.04) for paternal areca nut usage from 20 to 29 years of age, versus from >30 years of age (adjusted hazard ratio,1.61; 95% CI, 0.22-11.69). MetS offspring risk for paternal smoking increased dosewise (P trend <0.0001) with earlier age of onset (P trend =0.0009), independently. Conclusions: Longer duration of paternal betel quid chewing and smoking, prefatherhood, independently predicted early occurrence of incident MetS in offspring, corroborating previously reported transgenerational effects of these habits, and supporting the need for habit-cessation program provision.

KW - areca

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KW - cohort effect

KW - lime-piper

KW - metabolic syndrome X

KW - parents

KW - smoking

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