Long-term results of intensity-modulated radiotherapy concomitant with chemotherapy for hypopharyngeal carcinoma aimed at laryngeal preservation

Wen Shan Liu, Chung Han Hsin, Ying Hsiang Chou, Jung Tung Liu, Ming Fang Wu, Szu Wen Tseng, Jong Kang Lee, Hsien Chun Tseng, Tzu Hwei Wang, Mao Chang Su, Huei Lee

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Abstract

Background: The objective of this retrospective study is to investigate laryngeal preservation and long-term treatment results in hypopharyngeal carcinoma treated with intensity-modulated radiotherapy (IMRT) combined with chemotherapy.Methods: Twenty-seven patients with hypopharyngeal carcinoma (stage II-IV) were enrolled and underwent concurrent chemoradiotherapy. The chemotherapy regimens were monthly cisplatin and 5-fluorouracil for six patients and weekly cisplatin for 19 patients. All patients were treated with IMRT with simultaneous integrated boost technique. Acute and late toxicities were recorded based on CTCAE 3.0 (Common Terminology Criteria for Adverse Events).Results: The median follow-up time for survivors was 53.0 months (range 36-82 months). The initial complete response rate was 85.2%, with a laryngeal preservation rate of 63.0%. The 5-year functional laryngeal, local-regional control, disease-free and overall survival rates were 59.7%, 63.3%, 51.0% and 34.8%, respectively. The most common greater than or equal to grade 3 acute and late effects were dysphagia (63.0%, 17 of 27 patients) and laryngeal stricture (18.5%, 5 of 27 patients), respectively. Patients belonging to the high risk group showed significantly higher risk of tracheostomy compared to the low risk group (p = 0.014).Conclusions: After long-term follow-up, our results confirmed that patients with hypopharyngeal carcinoma treated with IMRT concurrent with platinum-based chemotherapy attain high functional laryngeal and local-regional control survival rates. However, the late effect of laryngeal stricture remains a problem, particularly for high risk group patients.

Original languageEnglish
Article number102
JournalBMC Cancer
Volume10
DOIs
Publication statusPublished - Mar 18 2010
Externally publishedYes

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Intensity-Modulated Radiotherapy
Carcinoma
Drug Therapy
Cisplatin
Pathologic Constriction
Survival Rate
Tracheostomy
Chemoradiotherapy
Deglutition Disorders
Platinum
Terminology
Fluorouracil
Disease-Free Survival
Survivors
Retrospective Studies

ASJC Scopus subject areas

  • Oncology
  • Cancer Research
  • Genetics

Cite this

Long-term results of intensity-modulated radiotherapy concomitant with chemotherapy for hypopharyngeal carcinoma aimed at laryngeal preservation. / Liu, Wen Shan; Hsin, Chung Han; Chou, Ying Hsiang; Liu, Jung Tung; Wu, Ming Fang; Tseng, Szu Wen; Lee, Jong Kang; Tseng, Hsien Chun; Wang, Tzu Hwei; Su, Mao Chang; Lee, Huei.

In: BMC Cancer, Vol. 10, 102, 18.03.2010.

Research output: Contribution to journalArticle

Liu, Wen Shan ; Hsin, Chung Han ; Chou, Ying Hsiang ; Liu, Jung Tung ; Wu, Ming Fang ; Tseng, Szu Wen ; Lee, Jong Kang ; Tseng, Hsien Chun ; Wang, Tzu Hwei ; Su, Mao Chang ; Lee, Huei. / Long-term results of intensity-modulated radiotherapy concomitant with chemotherapy for hypopharyngeal carcinoma aimed at laryngeal preservation. In: BMC Cancer. 2010 ; Vol. 10.
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abstract = "Background: The objective of this retrospective study is to investigate laryngeal preservation and long-term treatment results in hypopharyngeal carcinoma treated with intensity-modulated radiotherapy (IMRT) combined with chemotherapy.Methods: Twenty-seven patients with hypopharyngeal carcinoma (stage II-IV) were enrolled and underwent concurrent chemoradiotherapy. The chemotherapy regimens were monthly cisplatin and 5-fluorouracil for six patients and weekly cisplatin for 19 patients. All patients were treated with IMRT with simultaneous integrated boost technique. Acute and late toxicities were recorded based on CTCAE 3.0 (Common Terminology Criteria for Adverse Events).Results: The median follow-up time for survivors was 53.0 months (range 36-82 months). The initial complete response rate was 85.2{\%}, with a laryngeal preservation rate of 63.0{\%}. The 5-year functional laryngeal, local-regional control, disease-free and overall survival rates were 59.7{\%}, 63.3{\%}, 51.0{\%} and 34.8{\%}, respectively. The most common greater than or equal to grade 3 acute and late effects were dysphagia (63.0{\%}, 17 of 27 patients) and laryngeal stricture (18.5{\%}, 5 of 27 patients), respectively. Patients belonging to the high risk group showed significantly higher risk of tracheostomy compared to the low risk group (p = 0.014).Conclusions: After long-term follow-up, our results confirmed that patients with hypopharyngeal carcinoma treated with IMRT concurrent with platinum-based chemotherapy attain high functional laryngeal and local-regional control survival rates. However, the late effect of laryngeal stricture remains a problem, particularly for high risk group patients.",
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T1 - Long-term results of intensity-modulated radiotherapy concomitant with chemotherapy for hypopharyngeal carcinoma aimed at laryngeal preservation

AU - Liu, Wen Shan

AU - Hsin, Chung Han

AU - Chou, Ying Hsiang

AU - Liu, Jung Tung

AU - Wu, Ming Fang

AU - Tseng, Szu Wen

AU - Lee, Jong Kang

AU - Tseng, Hsien Chun

AU - Wang, Tzu Hwei

AU - Su, Mao Chang

AU - Lee, Huei

PY - 2010/3/18

Y1 - 2010/3/18

N2 - Background: The objective of this retrospective study is to investigate laryngeal preservation and long-term treatment results in hypopharyngeal carcinoma treated with intensity-modulated radiotherapy (IMRT) combined with chemotherapy.Methods: Twenty-seven patients with hypopharyngeal carcinoma (stage II-IV) were enrolled and underwent concurrent chemoradiotherapy. The chemotherapy regimens were monthly cisplatin and 5-fluorouracil for six patients and weekly cisplatin for 19 patients. All patients were treated with IMRT with simultaneous integrated boost technique. Acute and late toxicities were recorded based on CTCAE 3.0 (Common Terminology Criteria for Adverse Events).Results: The median follow-up time for survivors was 53.0 months (range 36-82 months). The initial complete response rate was 85.2%, with a laryngeal preservation rate of 63.0%. The 5-year functional laryngeal, local-regional control, disease-free and overall survival rates were 59.7%, 63.3%, 51.0% and 34.8%, respectively. The most common greater than or equal to grade 3 acute and late effects were dysphagia (63.0%, 17 of 27 patients) and laryngeal stricture (18.5%, 5 of 27 patients), respectively. Patients belonging to the high risk group showed significantly higher risk of tracheostomy compared to the low risk group (p = 0.014).Conclusions: After long-term follow-up, our results confirmed that patients with hypopharyngeal carcinoma treated with IMRT concurrent with platinum-based chemotherapy attain high functional laryngeal and local-regional control survival rates. However, the late effect of laryngeal stricture remains a problem, particularly for high risk group patients.

AB - Background: The objective of this retrospective study is to investigate laryngeal preservation and long-term treatment results in hypopharyngeal carcinoma treated with intensity-modulated radiotherapy (IMRT) combined with chemotherapy.Methods: Twenty-seven patients with hypopharyngeal carcinoma (stage II-IV) were enrolled and underwent concurrent chemoradiotherapy. The chemotherapy regimens were monthly cisplatin and 5-fluorouracil for six patients and weekly cisplatin for 19 patients. All patients were treated with IMRT with simultaneous integrated boost technique. Acute and late toxicities were recorded based on CTCAE 3.0 (Common Terminology Criteria for Adverse Events).Results: The median follow-up time for survivors was 53.0 months (range 36-82 months). The initial complete response rate was 85.2%, with a laryngeal preservation rate of 63.0%. The 5-year functional laryngeal, local-regional control, disease-free and overall survival rates were 59.7%, 63.3%, 51.0% and 34.8%, respectively. The most common greater than or equal to grade 3 acute and late effects were dysphagia (63.0%, 17 of 27 patients) and laryngeal stricture (18.5%, 5 of 27 patients), respectively. Patients belonging to the high risk group showed significantly higher risk of tracheostomy compared to the low risk group (p = 0.014).Conclusions: After long-term follow-up, our results confirmed that patients with hypopharyngeal carcinoma treated with IMRT concurrent with platinum-based chemotherapy attain high functional laryngeal and local-regional control survival rates. However, the late effect of laryngeal stricture remains a problem, particularly for high risk group patients.

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JO - BMC Cancer

JF - BMC Cancer

SN - 1471-2407

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