Long-term outcomes of native coarctation of the aorta after balloon angioplasty or surgical aortoplasty in newborns and young infants less than 3 months of age

Hsin Hui Chiu, Jou Kou Wang, Yih Shang Chen, Ing Sh Chiu, Chung I. Chang, Ming Tai Lin, Chun Wei Lu, Shuenn Nan Chiu, Chun An Chen, Mei Hwan Wu

Research output: Contribution to journalArticle

Abstract

Background: Balloon angioplasty of native coarctation of the aorta, though effective, is frequently associated with early restenosis, repeated interventions and aneurysm formation, especially in very young patients. However, available long-term data are limited. Methods: From Jan. 1986 to Dec. 2007, eighty-eight patients with simple aortic coarctation, isolated or associated with patent ductus arteriosus or ventricular septal defect, and survived angioplasty (n = 17) or surgery (n = 71) within 3 months of age in National Taiwan University Hospital were enrolled. Results: The average length of follow-up was 10.1 ± 5.1 years. The long-term outcomes between these two groups were comparable in hypertension, left ventricular outflow tract obstruction, and aortic aneurysm. Patients in the angioplasty group had a greater likelihood of reintervention (64.7% vs. 42.3%, p = 0.096) and repeated reintervention (29.4% vs. 7.0%, p = 0.027) as compared with surgery group. The 10-year freedom from reintervention was 35.3% and 59.2% in the angioplasty and surgery group, respectively (p = 0.046); there were no deaths reported in that 10-year span. Patients with angioplasty and those with patent ductus arteriosus were more likely to require surgical aortoplasty at reintervention. Conclusions: The long-term outcomes of aortic coarctation in newborns and young infants after balloon angioplasty were effective and beneficial. However, those outcomes were accompanied by concomitant higher risks of reintervention and surgical reintervention, particularly in those with patent ductus arteriosus.

Original languageEnglish
Pages (from-to)168-174
Number of pages7
JournalActa Cardiologica Sinica
Volume29
Issue number2
Publication statusPublished - Mar 2013
Externally publishedYes

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Aortic Coarctation
Balloon Angioplasty
Angioplasty
Patent Ductus Arteriosus
Newborn Infant
Ventricular Outflow Obstruction
Aortic Aneurysm
Ventricular Heart Septal Defects
Taiwan
Aneurysm
Hypertension

Keywords

  • Aortic operation
  • Coarctation
  • Infant
  • Outcomes

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine

Cite this

Long-term outcomes of native coarctation of the aorta after balloon angioplasty or surgical aortoplasty in newborns and young infants less than 3 months of age. / Chiu, Hsin Hui; Wang, Jou Kou; Chen, Yih Shang; Chiu, Ing Sh; Chang, Chung I.; Lin, Ming Tai; Lu, Chun Wei; Chiu, Shuenn Nan; Chen, Chun An; Wu, Mei Hwan.

In: Acta Cardiologica Sinica, Vol. 29, No. 2, 03.2013, p. 168-174.

Research output: Contribution to journalArticle

Chiu, HH, Wang, JK, Chen, YS, Chiu, IS, Chang, CI, Lin, MT, Lu, CW, Chiu, SN, Chen, CA & Wu, MH 2013, 'Long-term outcomes of native coarctation of the aorta after balloon angioplasty or surgical aortoplasty in newborns and young infants less than 3 months of age', Acta Cardiologica Sinica, vol. 29, no. 2, pp. 168-174.
Chiu, Hsin Hui ; Wang, Jou Kou ; Chen, Yih Shang ; Chiu, Ing Sh ; Chang, Chung I. ; Lin, Ming Tai ; Lu, Chun Wei ; Chiu, Shuenn Nan ; Chen, Chun An ; Wu, Mei Hwan. / Long-term outcomes of native coarctation of the aorta after balloon angioplasty or surgical aortoplasty in newborns and young infants less than 3 months of age. In: Acta Cardiologica Sinica. 2013 ; Vol. 29, No. 2. pp. 168-174.
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abstract = "Background: Balloon angioplasty of native coarctation of the aorta, though effective, is frequently associated with early restenosis, repeated interventions and aneurysm formation, especially in very young patients. However, available long-term data are limited. Methods: From Jan. 1986 to Dec. 2007, eighty-eight patients with simple aortic coarctation, isolated or associated with patent ductus arteriosus or ventricular septal defect, and survived angioplasty (n = 17) or surgery (n = 71) within 3 months of age in National Taiwan University Hospital were enrolled. Results: The average length of follow-up was 10.1 ± 5.1 years. The long-term outcomes between these two groups were comparable in hypertension, left ventricular outflow tract obstruction, and aortic aneurysm. Patients in the angioplasty group had a greater likelihood of reintervention (64.7{\%} vs. 42.3{\%}, p = 0.096) and repeated reintervention (29.4{\%} vs. 7.0{\%}, p = 0.027) as compared with surgery group. The 10-year freedom from reintervention was 35.3{\%} and 59.2{\%} in the angioplasty and surgery group, respectively (p = 0.046); there were no deaths reported in that 10-year span. Patients with angioplasty and those with patent ductus arteriosus were more likely to require surgical aortoplasty at reintervention. Conclusions: The long-term outcomes of aortic coarctation in newborns and young infants after balloon angioplasty were effective and beneficial. However, those outcomes were accompanied by concomitant higher risks of reintervention and surgical reintervention, particularly in those with patent ductus arteriosus.",
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AU - Chen, Yih Shang

AU - Chiu, Ing Sh

AU - Chang, Chung I.

AU - Lin, Ming Tai

AU - Lu, Chun Wei

AU - Chiu, Shuenn Nan

AU - Chen, Chun An

AU - Wu, Mei Hwan

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AB - Background: Balloon angioplasty of native coarctation of the aorta, though effective, is frequently associated with early restenosis, repeated interventions and aneurysm formation, especially in very young patients. However, available long-term data are limited. Methods: From Jan. 1986 to Dec. 2007, eighty-eight patients with simple aortic coarctation, isolated or associated with patent ductus arteriosus or ventricular septal defect, and survived angioplasty (n = 17) or surgery (n = 71) within 3 months of age in National Taiwan University Hospital were enrolled. Results: The average length of follow-up was 10.1 ± 5.1 years. The long-term outcomes between these two groups were comparable in hypertension, left ventricular outflow tract obstruction, and aortic aneurysm. Patients in the angioplasty group had a greater likelihood of reintervention (64.7% vs. 42.3%, p = 0.096) and repeated reintervention (29.4% vs. 7.0%, p = 0.027) as compared with surgery group. The 10-year freedom from reintervention was 35.3% and 59.2% in the angioplasty and surgery group, respectively (p = 0.046); there were no deaths reported in that 10-year span. Patients with angioplasty and those with patent ductus arteriosus were more likely to require surgical aortoplasty at reintervention. Conclusions: The long-term outcomes of aortic coarctation in newborns and young infants after balloon angioplasty were effective and beneficial. However, those outcomes were accompanied by concomitant higher risks of reintervention and surgical reintervention, particularly in those with patent ductus arteriosus.

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